Can a Prebiotic Formulation Reduce Frailty Levels in Older People?

Olga Theou, K. Jayanama, J. Fernández-Garrido, C. Buigues, L. Pruimboom, A. J. Hoogland, R. Navarro-Martínez, K. Rockwood, O. Cauli

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

50 Citas (Scopus)

Resumen

Objective: The purpose of this study was to examine whether a prebiotic formulation reduces frailty index (FI) levels in older people. Design: We conducted secondary analysis of a placebo-controlled, randomized, double-blind design study. Setting/Participants: The study included non-demented people over the age of 65 who were living in nursing homes and were able to walk. Fifty participants completed the study (75.3±7.3 years, 70% females). Intervention: Participants were randomly assigned to either a group who received daily Darmocare Pre® (inulin and fructooligosaccharides) for 13 weeks or a placebo group (maltodextrin). Measurement: The primary outcome in this secondary analysis was change in level of a 62-item FI compared to baseline. Results: At the 13-week follow-up, the placebo group had higher FI levels (preFI 0.23±0.11, postFI 0.24±0.12, p=0.012) and the intervention group had lower FI levels (preFI 0.22±0.09, postFI 0.20±0.08, p<0.001). There was an average increase of 0.01±0.01 in the FI score in the placebo group (0.4 deficits; Cohen’s d 0.61; standardized response mean 0.59) and an average reduction of 0.02±0.02 in the intervention group (1.1 deficits; Cohen’s d -1.35; standardized response mean -1.16). Among the 28 participants in the intervention group, FI levels were reduced for 25 people; five of them had an FI reduction greater than 0.03. The moderately/severely frail participants (FI >0.3, N=5) had the greatest reduction in their FI (0.04±0.01). Conclusion: A prebiotic intervention can reduce frailty levels in nursing home residents especially in those with higher levels of frailty.

Idioma originalEnglish
Páginas (desde-hasta)48-52
Número de páginas5
PublicaciónThe Journal of frailty &amp; aging
Volumen8
N.º1
DOI
EstadoPublished - ene. 2019

Nota bibliográfica

Funding Information:
Funding: Data collection for the clinical trial was supported by Grant number GV/043 from Conselleria de Educació-Generalitat Valenciana and a project contract between University of Valencia and Bonusan Besloten Vennootschap.

Publisher Copyright:
© 2019, Serdi and Springer Nature Switzerland AG.

ASJC Scopus Subject Areas

  • General Medicine

PubMed: MeSH publication types

  • Journal Article
  • Randomized Controlled Trial

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