Canadian consensus: Inhibition of ALK-positive tumours in advanced non-small-cell lung cancer

13 Citas (Scopus)

Resumen

Anaplastic lymphoma kinase (ALK) is an oncogenic driver in non-small-cell lung cancer (NSCLC). Chromosomal rearrangements involving the ALK gene occur in up to 4% of nonsquamous nsclc patients and lead to constitutive activation of the alk signalling pathway. ALK-positive nsclc is found in relatively young patients, with a median age of 50 years. Patients frequently have brain metastasis. Targeted inhibition of the alk pathway prolongs progression-free survival in patients with ALK-positive advanced nsclc. The results of several recent clinical trials confirm the efficacy and safety benefit of crizotinib and ceritinib in this population. Canadian oncologists support the following consensus statement: All patients with advanced nonsquamous nsclc (excluding pure neuroendocrine carcinoma) should be tested for the presence of an ALK rearrangement. If an ALK rearrangement is present, treatment with a targeted alk inhibitor in the first-line setting is recommended. As patients become resistant to first-generation alk inhibitors, other treatments, including second-generation ALK inhibitors can be considered.

Idioma originalEnglish
Páginas (desde-hasta)196-200
Número de páginas5
PublicaciónCurrent Oncology
Volumen23
N.º3
DOI
EstadoPublished - 2016
Publicado de forma externa

Nota bibliográfica

Publisher Copyright:
© 2016 Multimed Inc.

ASJC Scopus Subject Areas

  • Oncology

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