Cancer stem cells and chemoresistance: Strategies to overcome therapeutic resistance

Margaret L. Thomas, Krysta M. Coyle, Mohammad Sultan, Paola Marcato

Producción científica: Capítulo en Libro/Reporte/Acta de conferenciaCapítulo

2 Citas (Scopus)

Resumen

Cancer stem cells (CSCs) are hypothesized to initiate cancer and give rise to heterogeneous tumors made up of self-renewing CSCs and the differentiated, less tumorigenic non-CSCs, which make up the bulk of the tumor. Importantly, in terms of successful patient treatment, CSCs are also more resistant to commonly used chemotherapeutics. Multiple mechanisms have been identified for CSCassociated chemoresistance. These mechanisms include increased expression of ABC transporter efflux pumps, aldehyde dehydrogenase (ALDH) detoxification enzymes, anti-apoptosis proteins, enhanced DNA repair mechanisms, increased activation of the embryonic signaling pathways (Notch, Wnt and Hedgehog), and quiescence. Identification of these mechanisms has led to development of specific strategies to circumvent CSC-associated chemoresistance (e.g. inhibitors of ABC transporters, ALDH enzymes, and Notch, Wnt, and Hedgehog pathways, and epigenetic modifying drugs). Future clinical evidence will reveal if employing these adjuvant therapies will eradicate CSCs along with the bulk of the tumor, and lead to improved patient outcomes with decreased cancer recurrence.

Idioma originalEnglish
Título de la publicación alojadaCancer Stem Cells
Subtítulo de la publicación alojadaEmerging Concepts and Future Perspectives in Translational Oncology
EditorialSpringer International Publishing
Páginas477-518
Número de páginas42
ISBN (versión digital)9783319210308
ISBN (versión impresa)9783319210292
DOI
EstadoPublished - ene. 1 2015

Nota bibliográfica

Publisher Copyright:
© Springer International Publishing Switzerland 2015.

ASJC Scopus Subject Areas

  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • General Biochemistry,Genetics and Molecular Biology

Huella

Profundice en los temas de investigación de 'Cancer stem cells and chemoresistance: Strategies to overcome therapeutic resistance'. En conjunto forman una huella única.

Citar esto