Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease

Sonia S. Anand; Jack V. Tu; Dipika Desai; Phillip Awadalla; Paula Robson; Sébastien Jacquemont; Trevor Dummer; Nhu Le; Louise Parker; Paul Poirier; Koon Teo; Scott A. Lear; Salim Yusuf; Jean Claude Tardif; Francois Marcotte; David Busseuil; Jean Pierre Després; Sandra E. Black; Anish Kirpalani; Grace Parraga; Michael D. Noseworthy; Alexander Dick; Jonathan Leipsic; David Kelton; Jennifer Vena; Melissa Thomas; Karleen M. Schulze; Eric Larose; Alan R. Moody; Eric E. Smith; Matthias G. Friedrich

doi:10.1093/ehjci/jez226

Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease

Sonia S. Anand, Jack V. Tu, Dipika Desai, Phillip Awadalla, Paula Robson, Sébastien Jacquemont, Trevor Dummer, Nhu Le, Louise Parker, Paul Poirier, Koon Teo, Scott A. Lear, Salim Yusuf, Jean Claude Tardif, Francois Marcotte, David Busseuil, Jean Pierre Després, Sandra E. Black, Anish Kirpalani, Grace ParragaMichael D. Noseworthy, Alexander Dick, Jonathan Leipsic, David Kelton, Jennifer Vena, Melissa Thomas, Karleen M. Schulze, Eric Larose, Alan R. Moody, Eric E. Smith, Matthias G. Friedrich

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

14 Citas (Scopus)

Resumen

Aims: Cardiovascular risk factors are used for risk stratification in primary prevention. We sought to determine if simple cardiac risk scores are associated with magnetic resonance imaging (MRI)-detected subclinical cerebrovascular disease including carotid wall volume (CWV), carotid intraplaque haemorrhage (IPH), and silent brain infarction (SBI). Methods and results: A total of 7594 adults with no history of cardiovascular disease (CVD) underwent risk factor assessment and a non-contrast enhanced MRI of the carotid arteries and brain using a standardized protocol in a population-based cohort recruited between 2014 and 2018. The non-lab-based INTERHEART risk score (IHRS) was calculated in all participants; the Framingham Risk Score was calculated in a subset who provided blood samples (n = 3889). The association between these risk scores and MRI measures of CWV, carotid IPH, and SBI was determined. The mean age of the cohort was 58 (8.9) years, 55% were women. Each 5-point increase (~1 SD) in the IHRS was associated with a 9 mm3 increase in CWV, adjusted for sex (P < 0.0001), a 23% increase in IPH [95% confidence interval (CI) 9-38%], and a 32% (95% CI 20-45%) increase in SBI. These associations were consistent for lacunar and non-lacunar brain infarction. The Framingham Risk Score was also significantly associated with CWV, IPH, and SBI. CWV was additive and independent to the risk scores in its association with IPH and SBI. Conclusion: Simple cardiovascular risk scores are significantly associated with the presence of MRI-detected subclinical cerebrovascular disease, including CWV, IPH, and SBI in an adult population without known clinical CVD.

Idioma original	English
Páginas (desde-hasta)	692-700
Número de páginas	9
Publicación	European Heart Journal Cardiovascular Imaging
Volumen	21
N.º	6
DOI	https://doi.org/10.1093/ehjci/jez226
Estado	Published - jun. 1 2020

Nota bibliográfica

Funding Information:
... Funding ... CAHHM was funded by the Canadian Partnership Against Cancer ... (CPAC), Heart and Stroke Foundation of Canada (HSF-Canada), and ..tionswere asloreceivedfromthe PopulationHealthResearch.the CanadianInstitutesof HealthResearch(CIHR).Financialcontribu- ..Institute and CIHR Foundation Grant no. FDN-143255 to S.S.A.;. ..FDN-143313 to J.V.T.; and FDN 154317 to E.E.S. In-kind contributions. ..from A.R.M. and S.E.B. from Sunnybrook Hospital, Toronto for MRI. ..reading costs, and Bayer AG for provision of IV contrast. The. ..Canadian Partnership for Tomorrow Project is funded by the. ... Canadian Partnership Against Cancer, BC Cancer Foundation, ... Genome Quebec, Ontario Institute for Cancer Research and Alberta ... Health and the Alberta Cancer Prevention Legacy Fund, Alberta ..ces.21 TheMontrealHeartInstituteBiobankis fundedby Mr Andre´.CancerFoundation. ThePUREStudywas fundedby multiplesour- ..Desmarais and Mrs France Chre´tien-Desmarais and the Montreal. ..Heart Institute Foundation. S.S.A. was supported by a Tier 1 Canada. ..Research Chair in Ethnicity and Cardiovascular Disease and Heart and. ..Stroke Foundation Chair in Population Health. P.A. was supported by. ..a Ministry of Research and Innovation of Ontario Investigator Award.. ... S.E.B. was supported by the Hurvitz Brain Sciences Research Program, ... Sunnybrook Research Institute, and the Department of Medicine, ... Sunnybrook Health Sciences Centre, University of Toronto. J.P.D. is ..Risksupportedby theFoundation of Universite´Laval.E.L. was sup-.the scientific directorofthe InternationalChaironCardiometabolic ..ported by the Laval University Chair of Research & Innovation in. ..Cardiovascular Imaging and the Fonds de recherche du Que´bec—. ..Sante´. G.P. holds a Tier 1 Canada Research Chair in Lung Imaging to. ..Transform Outcomes. J.L. holds a Canada Research Chair Tier 2 in. ... Advanced Cardiopulmonary Imaging at University of British Columbia. ... L.P. holds the Canadian Cancer Society Chair in Population Cancer ... Research at Dalhousie University. G.P. was supported by a Western ..Chairintranslational andpersonalized medicineandthe Universite´ de.FacultyScholarAward.J.-C.T.holdsthe Tier1 CanadaResearch ..Montre´al Pfizer endowed research chair in atherosclerosis. J.V.T. was. ..supported by a Tier 1 Canada Research Chair in Health Services. ..Research and an Eaton Scholar award. S.Y. was supported by the. ..Heart & Stroke Foundation/Marion W. Burke Chair in Cardiovascular. ..Disease. Some of the data used in this research were made available. ... by the Canadian Partnership for Tomorrow Project along with BC ... Generations Project, Alberta’s tomorrow Project, Ontario Health ... Study, CARTaGENE, and the Atlantic PATH. Data were harmonized ..theCentre of GenomicsandPolicyin collaborationwiththe Cohorts..by Maelstromand accesspoliciesandproceduresweredevelopedby ...

Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.

ASJC Scopus Subject Areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.1093/ehjci/jez226

Otros archivos y enlaces

Citar esto

Anand, S. S., Tu, J. V., Desai, D., Awadalla, P., Robson, P., Jacquemont, S., Dummer, T., Le, N., Parker, L., Poirier, P., Teo, K., Lear, S. A., Yusuf, S., Tardif, J. C., Marcotte, F., Busseuil, D., Després, J. P., Black, S. E., Kirpalani, A., ... Friedrich, M. G. (2020). Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease. European Heart Journal Cardiovascular Imaging, 21(6), 692-700. https://doi.org/10.1093/ehjci/jez226

Anand, SS, Tu, JV, Desai, D, Awadalla, P, Robson, P, Jacquemont, S, Dummer, T, Le, N, Parker, L, Poirier, P, Teo, K, Lear, SA, Yusuf, S, Tardif, JC, Marcotte, F, Busseuil, D, Després, JP, Black, SE, Kirpalani, A, Parraga, G, Noseworthy, MD, Dick, A, Leipsic, J, Kelton, D, Vena, J, Thomas, M, Schulze, KM, Larose, E, Moody, AR, Smith, EE & Friedrich, MG 2020, 'Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease', European Heart Journal Cardiovascular Imaging, vol. 21, n.º 6, pp. 692-700. https://doi.org/10.1093/ehjci/jez226

@article{ecd7767f260746fc9487858d3a588166,

title = "Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease",

abstract = "Aims: Cardiovascular risk factors are used for risk stratification in primary prevention. We sought to determine if simple cardiac risk scores are associated with magnetic resonance imaging (MRI)-detected subclinical cerebrovascular disease including carotid wall volume (CWV), carotid intraplaque haemorrhage (IPH), and silent brain infarction (SBI). Methods and results: A total of 7594 adults with no history of cardiovascular disease (CVD) underwent risk factor assessment and a non-contrast enhanced MRI of the carotid arteries and brain using a standardized protocol in a population-based cohort recruited between 2014 and 2018. The non-lab-based INTERHEART risk score (IHRS) was calculated in all participants; the Framingham Risk Score was calculated in a subset who provided blood samples (n = 3889). The association between these risk scores and MRI measures of CWV, carotid IPH, and SBI was determined. The mean age of the cohort was 58 (8.9) years, 55% were women. Each 5-point increase (~1 SD) in the IHRS was associated with a 9 mm3 increase in CWV, adjusted for sex (P < 0.0001), a 23% increase in IPH [95% confidence interval (CI) 9-38%], and a 32% (95% CI 20-45%) increase in SBI. These associations were consistent for lacunar and non-lacunar brain infarction. The Framingham Risk Score was also significantly associated with CWV, IPH, and SBI. CWV was additive and independent to the risk scores in its association with IPH and SBI. Conclusion: Simple cardiovascular risk scores are significantly associated with the presence of MRI-detected subclinical cerebrovascular disease, including CWV, IPH, and SBI in an adult population without known clinical CVD.",

author = "Anand, {Sonia S.} and Tu, {Jack V.} and Dipika Desai and Phillip Awadalla and Paula Robson and S{\'e}bastien Jacquemont and Trevor Dummer and Nhu Le and Louise Parker and Paul Poirier and Koon Teo and Lear, {Scott A.} and Salim Yusuf and Tardif, {Jean Claude} and Francois Marcotte and David Busseuil and Despr{\'e}s, {Jean Pierre} and Black, {Sandra E.} and Anish Kirpalani and Grace Parraga and Noseworthy, {Michael D.} and Alexander Dick and Jonathan Leipsic and David Kelton and Jennifer Vena and Melissa Thomas and Schulze, {Karleen M.} and Eric Larose and Moody, {Alan R.} and Smith, {Eric E.} and Friedrich, {Matthias G.}",

note = "Funding Information: ... Funding ... CAHHM was funded by the Canadian Partnership Against Cancer ... (CPAC), Heart and Stroke Foundation of Canada (HSF-Canada), and ..tionswere asloreceivedfromthe PopulationHealthResearch.the CanadianInstitutesof HealthResearch(CIHR).Financialcontribu- ..Institute and CIHR Foundation Grant no. FDN-143255 to S.S.A.;. ..FDN-143313 to J.V.T.; and FDN 154317 to E.E.S. In-kind contributions. ..from A.R.M. and S.E.B. from Sunnybrook Hospital, Toronto for MRI. ..reading costs, and Bayer AG for provision of IV contrast. The. ..Canadian Partnership for Tomorrow Project is funded by the. ... Canadian Partnership Against Cancer, BC Cancer Foundation, ... Genome Quebec, Ontario Institute for Cancer Research and Alberta ... Health and the Alberta Cancer Prevention Legacy Fund, Alberta ..ces.21 TheMontrealHeartInstituteBiobankis fundedby Mr Andre´.CancerFoundation. ThePUREStudywas fundedby multiplesour- ..Desmarais and Mrs France Chre´tien-Desmarais and the Montreal. ..Heart Institute Foundation. S.S.A. was supported by a Tier 1 Canada. ..Research Chair in Ethnicity and Cardiovascular Disease and Heart and. ..Stroke Foundation Chair in Population Health. P.A. was supported by. ..a Ministry of Research and Innovation of Ontario Investigator Award.. ... S.E.B. was supported by the Hurvitz Brain Sciences Research Program, ... Sunnybrook Research Institute, and the Department of Medicine, ... Sunnybrook Health Sciences Centre, University of Toronto. J.P.D. is ..Risksupportedby theFoundation of Universite´Laval.E.L. was sup-.the scientific directorofthe InternationalChaironCardiometabolic ..ported by the Laval University Chair of Research & Innovation in. ..Cardiovascular Imaging and the Fonds de recherche du Que´bec—. ..Sante´. G.P. holds a Tier 1 Canada Research Chair in Lung Imaging to. ..Transform Outcomes. J.L. holds a Canada Research Chair Tier 2 in. ... Advanced Cardiopulmonary Imaging at University of British Columbia. ... L.P. holds the Canadian Cancer Society Chair in Population Cancer ... Research at Dalhousie University. G.P. was supported by a Western ..Chairintranslational andpersonalized medicineandthe Universite´ de.FacultyScholarAward.J.-C.T.holdsthe Tier1 CanadaResearch ..Montre´al Pfizer endowed research chair in atherosclerosis. J.V.T. was. ..supported by a Tier 1 Canada Research Chair in Health Services. ..Research and an Eaton Scholar award. S.Y. was supported by the. ..Heart & Stroke Foundation/Marion W. Burke Chair in Cardiovascular. ..Disease. Some of the data used in this research were made available. ... by the Canadian Partnership for Tomorrow Project along with BC ... Generations Project, Alberta{\textquoteright}s tomorrow Project, Ontario Health ... Study, CARTaGENE, and the Atlantic PATH. Data were harmonized ..theCentre of GenomicsandPolicyin collaborationwiththe Cohorts..by Maelstromand accesspoliciesandproceduresweredevelopedby ... Publisher Copyright: {\textcopyright} 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.",

year = "2020",

month = jun,

day = "1",

doi = "10.1093/ehjci/jez226",

language = "English",

volume = "21",

pages = "692--700",

journal = "European Heart Journal Cardiovascular Imaging",

issn = "2047-2404",

publisher = "Oxford University Press",

number = "6",

}

TY - JOUR

T1 - Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease

AU - Anand, Sonia S.

AU - Tu, Jack V.

AU - Desai, Dipika

AU - Awadalla, Phillip

AU - Robson, Paula

AU - Jacquemont, Sébastien

AU - Dummer, Trevor

AU - Le, Nhu

AU - Parker, Louise

AU - Poirier, Paul

AU - Teo, Koon

AU - Lear, Scott A.

AU - Yusuf, Salim

AU - Tardif, Jean Claude

AU - Marcotte, Francois

AU - Busseuil, David

AU - Després, Jean Pierre

AU - Black, Sandra E.

AU - Kirpalani, Anish

AU - Parraga, Grace

AU - Noseworthy, Michael D.

AU - Dick, Alexander

AU - Leipsic, Jonathan

AU - Kelton, David

AU - Vena, Jennifer

AU - Thomas, Melissa

AU - Schulze, Karleen M.

AU - Larose, Eric

AU - Moody, Alan R.

AU - Smith, Eric E.

AU - Friedrich, Matthias G.

N1 - Funding Information: ... Funding ... CAHHM was funded by the Canadian Partnership Against Cancer ... (CPAC), Heart and Stroke Foundation of Canada (HSF-Canada), and ..tionswere asloreceivedfromthe PopulationHealthResearch.the CanadianInstitutesof HealthResearch(CIHR).Financialcontribu- ..Institute and CIHR Foundation Grant no. FDN-143255 to S.S.A.;. ..FDN-143313 to J.V.T.; and FDN 154317 to E.E.S. In-kind contributions. ..from A.R.M. and S.E.B. from Sunnybrook Hospital, Toronto for MRI. ..reading costs, and Bayer AG for provision of IV contrast. The. ..Canadian Partnership for Tomorrow Project is funded by the. ... Canadian Partnership Against Cancer, BC Cancer Foundation, ... Genome Quebec, Ontario Institute for Cancer Research and Alberta ... Health and the Alberta Cancer Prevention Legacy Fund, Alberta ..ces.21 TheMontrealHeartInstituteBiobankis fundedby Mr Andre´.CancerFoundation. ThePUREStudywas fundedby multiplesour- ..Desmarais and Mrs France Chre´tien-Desmarais and the Montreal. ..Heart Institute Foundation. S.S.A. was supported by a Tier 1 Canada. ..Research Chair in Ethnicity and Cardiovascular Disease and Heart and. ..Stroke Foundation Chair in Population Health. P.A. was supported by. ..a Ministry of Research and Innovation of Ontario Investigator Award.. ... S.E.B. was supported by the Hurvitz Brain Sciences Research Program, ... Sunnybrook Research Institute, and the Department of Medicine, ... Sunnybrook Health Sciences Centre, University of Toronto. J.P.D. is ..Risksupportedby theFoundation of Universite´Laval.E.L. was sup-.the scientific directorofthe InternationalChaironCardiometabolic ..ported by the Laval University Chair of Research & Innovation in. ..Cardiovascular Imaging and the Fonds de recherche du Que´bec—. ..Sante´. G.P. holds a Tier 1 Canada Research Chair in Lung Imaging to. ..Transform Outcomes. J.L. holds a Canada Research Chair Tier 2 in. ... Advanced Cardiopulmonary Imaging at University of British Columbia. ... L.P. holds the Canadian Cancer Society Chair in Population Cancer ... Research at Dalhousie University. G.P. was supported by a Western ..Chairintranslational andpersonalized medicineandthe Universite´ de.FacultyScholarAward.J.-C.T.holdsthe Tier1 CanadaResearch ..Montre´al Pfizer endowed research chair in atherosclerosis. J.V.T. was. ..supported by a Tier 1 Canada Research Chair in Health Services. ..Research and an Eaton Scholar award. S.Y. was supported by the. ..Heart & Stroke Foundation/Marion W. Burke Chair in Cardiovascular. ..Disease. Some of the data used in this research were made available. ... by the Canadian Partnership for Tomorrow Project along with BC ... Generations Project, Alberta’s tomorrow Project, Ontario Health ... Study, CARTaGENE, and the Atlantic PATH. Data were harmonized ..theCentre of GenomicsandPolicyin collaborationwiththe Cohorts..by Maelstromand accesspoliciesandproceduresweredevelopedby ... Publisher Copyright: © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Aims: Cardiovascular risk factors are used for risk stratification in primary prevention. We sought to determine if simple cardiac risk scores are associated with magnetic resonance imaging (MRI)-detected subclinical cerebrovascular disease including carotid wall volume (CWV), carotid intraplaque haemorrhage (IPH), and silent brain infarction (SBI). Methods and results: A total of 7594 adults with no history of cardiovascular disease (CVD) underwent risk factor assessment and a non-contrast enhanced MRI of the carotid arteries and brain using a standardized protocol in a population-based cohort recruited between 2014 and 2018. The non-lab-based INTERHEART risk score (IHRS) was calculated in all participants; the Framingham Risk Score was calculated in a subset who provided blood samples (n = 3889). The association between these risk scores and MRI measures of CWV, carotid IPH, and SBI was determined. The mean age of the cohort was 58 (8.9) years, 55% were women. Each 5-point increase (~1 SD) in the IHRS was associated with a 9 mm3 increase in CWV, adjusted for sex (P < 0.0001), a 23% increase in IPH [95% confidence interval (CI) 9-38%], and a 32% (95% CI 20-45%) increase in SBI. These associations were consistent for lacunar and non-lacunar brain infarction. The Framingham Risk Score was also significantly associated with CWV, IPH, and SBI. CWV was additive and independent to the risk scores in its association with IPH and SBI. Conclusion: Simple cardiovascular risk scores are significantly associated with the presence of MRI-detected subclinical cerebrovascular disease, including CWV, IPH, and SBI in an adult population without known clinical CVD.

AB - Aims: Cardiovascular risk factors are used for risk stratification in primary prevention. We sought to determine if simple cardiac risk scores are associated with magnetic resonance imaging (MRI)-detected subclinical cerebrovascular disease including carotid wall volume (CWV), carotid intraplaque haemorrhage (IPH), and silent brain infarction (SBI). Methods and results: A total of 7594 adults with no history of cardiovascular disease (CVD) underwent risk factor assessment and a non-contrast enhanced MRI of the carotid arteries and brain using a standardized protocol in a population-based cohort recruited between 2014 and 2018. The non-lab-based INTERHEART risk score (IHRS) was calculated in all participants; the Framingham Risk Score was calculated in a subset who provided blood samples (n = 3889). The association between these risk scores and MRI measures of CWV, carotid IPH, and SBI was determined. The mean age of the cohort was 58 (8.9) years, 55% were women. Each 5-point increase (~1 SD) in the IHRS was associated with a 9 mm3 increase in CWV, adjusted for sex (P < 0.0001), a 23% increase in IPH [95% confidence interval (CI) 9-38%], and a 32% (95% CI 20-45%) increase in SBI. These associations were consistent for lacunar and non-lacunar brain infarction. The Framingham Risk Score was also significantly associated with CWV, IPH, and SBI. CWV was additive and independent to the risk scores in its association with IPH and SBI. Conclusion: Simple cardiovascular risk scores are significantly associated with the presence of MRI-detected subclinical cerebrovascular disease, including CWV, IPH, and SBI in an adult population without known clinical CVD.

UR - http://www.scopus.com/inward/record.url?scp=85076761487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076761487&partnerID=8YFLogxK

U2 - 10.1093/ehjci/jez226

DO - 10.1093/ehjci/jez226

M3 - Article

C2 - 31565735

AN - SCOPUS:85076761487

SN - 2047-2404

VL - 21

SP - 692

EP - 700

JO - European Heart Journal Cardiovascular Imaging

JF - European Heart Journal Cardiovascular Imaging

IS - 6

ER -

Cardiovascular risk scoring and magnetic resonance imaging detected subclinical cerebrovascular disease

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto