TY - JOUR
T1 - Cell cycle regulation to repair the infarcted myocardium
AU - Dowell, Joshua D.
AU - Field, Loren J.
AU - Pasumarthi, Kishore B.S.
PY - 2003/7
Y1 - 2003/7
N2 - Lower vertebrates such as newt and zebrafish are able to reactivate high levels of cardiomyocyte cell cycle activity in response to experimental injury resulting in apparent regeneration. In contrast, damaged myocardium is replaced by fibrotic scar tissue in higher vertebrates. This process compromises the contractile function of the surviving myocardium, ultimately leading to heart failure. Various strategies are being pursued to augment myocyte number in the diseased hearts. One approach entails the reactivation of cell cycle in surviving cardiomyocytes. Here, we provide a summary of methods to monitor cell cycle activity, and interventions demonstrating positive cell cycle effects in cardiomyocytes as well as discuss the potential utility of cell cycle regulation to augment myocyte number in diseased hearts.
AB - Lower vertebrates such as newt and zebrafish are able to reactivate high levels of cardiomyocyte cell cycle activity in response to experimental injury resulting in apparent regeneration. In contrast, damaged myocardium is replaced by fibrotic scar tissue in higher vertebrates. This process compromises the contractile function of the surviving myocardium, ultimately leading to heart failure. Various strategies are being pursued to augment myocyte number in the diseased hearts. One approach entails the reactivation of cell cycle in surviving cardiomyocytes. Here, we provide a summary of methods to monitor cell cycle activity, and interventions demonstrating positive cell cycle effects in cardiomyocytes as well as discuss the potential utility of cell cycle regulation to augment myocyte number in diseased hearts.
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U2 - 10.1023/A:1024738104722
DO - 10.1023/A:1024738104722
M3 - Review article
C2 - 12878839
AN - SCOPUS:0042564561
SN - 1382-4147
VL - 8
SP - 293
EP - 303
JO - Heart Failure Reviews
JF - Heart Failure Reviews
IS - 3
ER -