Cellular costs underpin micronutrient limitation in phytoplankton

J. Scott P. McCain; Alessandro Tagliabue; Edward Susko; Eric P. Achterberg; Andrew E. Allen; Erin M. Bertrand

doi:10.1126/sciadv.abg6501

Cellular costs underpin micronutrient limitation in phytoplankton

J. Scott P. McCain, Alessandro Tagliabue, Edward Susko, Eric P. Achterberg, Andrew E. Allen, Erin M. Bertrand

Medicine

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24 Citas (Scopus)

Resumen

Micronutrients control phytoplankton growth in the ocean, influencing carbon export and fisheries. It is currently unclear how micronutrient scarcity affects cellular processes and how interdependence across micronutrients arises. We show that proximate causes of micronutrient growth limitation and interdependence are governed by cumulative cellular costs of acquiring and using micronutrients. Using a mechanistic proteomic allocation model of a polar diatom focused on iron and manganese, we demonstrate how cellular processes fundamentally underpin micronutrient limitation, and how they interact and compensate for each other to shape cellular elemental stoichiometry and resource interdependence. We coupled our model with metaproteomic and environmental data, yielding an approach for estimating biogeochemical metrics, including taxon-specific growth rates. Our results show that cumulative cellular costs govern how environmental conditions modify phytoplankton growth.

Idioma original	English
Número de artículo	eabg6501
Publicación	Science advances
Volumen	7
N.º	32
DOI	https://doi.org/10.1126/sciadv.abg6501
Estado	Published - ago. 2021

Nota bibliográfica

Funding Information:
J.S.P.M. acknowledges support from the NSERC CREATE Transatlantic Ocean System Science and Technology Program and the Killam Scholarship. This project was financially supported by NSERC Discovery Grant RGPIN-2015-05009 to E.M.B.; Simons Foundation Grant 504183 to E.M.B.; an NSERC CGS Postgraduate scholarship to J.S.P.M.; European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 724289) to A.T.; NSF-ANT-1043671, NSF-OCE-1756884, and Gordon and Betty Moore Foundation Grant GBMF3828 to A.E.A.; and a Google Cloud Research Credit Grant to E.M.B. E.S. was supported by a Discovery Grant from NSERC. Author contributions: J.S.P.M., A.T., E.P.A., and E.M.B. We are grateful to N. Youssef and L. Jabre for discussions and comments on the manuscript. We thank A. Cohen from the Dalhousie Biological Mass Spectrometry Core Facility for assistance with mass spectrometry data acquisition, Compute Canada for computational resources, the Ocean Biology Processing Group for data, L. Jabre for help with Fe' calculations, M. Faizi for correspondence about the modeling framework, and A. Sawatzky for assistance with schematic in Fig. 5A. We thank D. Hutchins, J. Hoffman, R. Sipler, J. Spackeen, and D. Bronk, as well as Antarctic Support Contractors and the staff at McMurdo Station for support in the field. Funding

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Copyright © 2021 The Authors.

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title = "Cellular costs underpin micronutrient limitation in phytoplankton",

abstract = "Micronutrients control phytoplankton growth in the ocean, influencing carbon export and fisheries. It is currently unclear how micronutrient scarcity affects cellular processes and how interdependence across micronutrients arises. We show that proximate causes of micronutrient growth limitation and interdependence are governed by cumulative cellular costs of acquiring and using micronutrients. Using a mechanistic proteomic allocation model of a polar diatom focused on iron and manganese, we demonstrate how cellular processes fundamentally underpin micronutrient limitation, and how they interact and compensate for each other to shape cellular elemental stoichiometry and resource interdependence. We coupled our model with metaproteomic and environmental data, yielding an approach for estimating biogeochemical metrics, including taxon-specific growth rates. Our results show that cumulative cellular costs govern how environmental conditions modify phytoplankton growth. ",

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note = "Funding Information: J.S.P.M. acknowledges support from the NSERC CREATE Transatlantic Ocean System Science and Technology Program and the Killam Scholarship. This project was financially supported by NSERC Discovery Grant RGPIN-2015-05009 to E.M.B.; Simons Foundation Grant 504183 to E.M.B.; an NSERC CGS Postgraduate scholarship to J.S.P.M.; European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 724289) to A.T.; NSF-ANT-1043671, NSF-OCE-1756884, and Gordon and Betty Moore Foundation Grant GBMF3828 to A.E.A.; and a Google Cloud Research Credit Grant to E.M.B. E.S. was supported by a Discovery Grant from NSERC. Author contributions: J.S.P.M., A.T., E.P.A., and E.M.B. We are grateful to N. Youssef and L. Jabre for discussions and comments on the manuscript. We thank A. Cohen from the Dalhousie Biological Mass Spectrometry Core Facility for assistance with mass spectrometry data acquisition, Compute Canada for computational resources, the Ocean Biology Processing Group for data, L. Jabre for help with Fe' calculations, M. Faizi for correspondence about the modeling framework, and A. Sawatzky for assistance with schematic in Fig. 5A. We thank D. Hutchins, J. Hoffman, R. Sipler, J. Spackeen, and D. Bronk, as well as Antarctic Support Contractors and the staff at McMurdo Station for support in the field. Funding Publisher Copyright: Copyright {\textcopyright} 2021 The Authors.",

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AU - Bertrand, Erin M.

N1 - Funding Information: J.S.P.M. acknowledges support from the NSERC CREATE Transatlantic Ocean System Science and Technology Program and the Killam Scholarship. This project was financially supported by NSERC Discovery Grant RGPIN-2015-05009 to E.M.B.; Simons Foundation Grant 504183 to E.M.B.; an NSERC CGS Postgraduate scholarship to J.S.P.M.; European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 724289) to A.T.; NSF-ANT-1043671, NSF-OCE-1756884, and Gordon and Betty Moore Foundation Grant GBMF3828 to A.E.A.; and a Google Cloud Research Credit Grant to E.M.B. E.S. was supported by a Discovery Grant from NSERC. Author contributions: J.S.P.M., A.T., E.P.A., and E.M.B. We are grateful to N. Youssef and L. Jabre for discussions and comments on the manuscript. We thank A. Cohen from the Dalhousie Biological Mass Spectrometry Core Facility for assistance with mass spectrometry data acquisition, Compute Canada for computational resources, the Ocean Biology Processing Group for data, L. Jabre for help with Fe' calculations, M. Faizi for correspondence about the modeling framework, and A. Sawatzky for assistance with schematic in Fig. 5A. We thank D. Hutchins, J. Hoffman, R. Sipler, J. Spackeen, and D. Bronk, as well as Antarctic Support Contractors and the staff at McMurdo Station for support in the field. Funding Publisher Copyright: Copyright © 2021 The Authors.

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Cellular costs underpin micronutrient limitation in phytoplankton

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PubMed: MeSH publication types

ODS de las Naciones Unidas

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