Ceramides and their interactive effects with trimethylamine-N-oxide metabolites on risk of gestational diabetes: A nested case-control study

Jinnan Liu; Jing Li; Kai Yang; Junhong Leng; Weiqin Li; Wen Yang; Xiaoxu Huo; Zhijie Yu; Ronald CW Ma; Gang Hu; Zhongze Fang; Xilin Yang

doi:10.1016/j.diabres.2020.108606

Ceramides and their interactive effects with trimethylamine-N-oxide metabolites on risk of gestational diabetes: A nested case-control study

Jinnan Liu, Jing Li, Kai Yang, Junhong Leng, Weiqin Li, Wen Yang, Xiaoxu Huo, Zhijie Yu, Ronald CW Ma, Gang Hu, Zhongze Fang, Xilin Yang

Medicine

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11 Citas (Scopus)

Resumen

Aims: To explore associations between ceramides in early pregnancy and gestational diabetes mellitus (GDM); and interactions between ceramides and trimethylamine N-oxide (TMAO) metabolites for GDM. Methods: We organized a 1:1 nested case-control study (n = 486) from a prospective cohort of pregnant women. Conditional logistic regression and additive interaction were performed to examine relationships between ceramides and TMAO metabolites for GDM. We defined trimethylamine (TMA) conversion ratio (TMA_R) as TMA/its precursors and TMAO conversion ratio (TMAO_R) as TMAO/TMA. Copresence of high TMA_R and low TMAO_R indicated TMA accumulation status. Results: High ceramides 18:0 (per SD), 18:1 (per SD) and low ceramide 24:0 (≤ 3.60 nmol/mL) were associated with increased GDM risk (OR: 1.69, 1.72 & 3.59, respectively). High TMA enhanced the OR of low ceramide 24:0 for GDM from 1.53 (95%CI: 0.88–2.66) to 10.3 (2.83–37.5), high TMA_R enhanced it from 1.31 (0.67–2.56) to 24.3 (6.57–89.5) and TMA accumulation enhanced it from 1.42 (0.72–2.77) to 25.5 (6.80–95.7), with all additive interactions being significant. However, the interactions between high ceramide 18 and TMAO metabolites were not significant. Conclusions: High ceramides 18:0, 18:1 and low ceramide 24:0 in early pregnancy were associated with increased GDM risk. Notably, TMA accumulation greatly amplified the risk-promoting effect of low ceramide 24:0 for GDM.

Idioma original	English
Número de artículo	108606
Publicación	Diabetes Research and Clinical Practice
Volumen	171
DOI	https://doi.org/10.1016/j.diabres.2020.108606
Estado	Published - ene. 2021

Nota bibliográfica

Funding Information:
This research was supported by the National Key Research and Development Program of China (Grant No: 2018YFC1313900; 2018YFC1313903; 2019YFA0802300; 2019YFA0802302) and the National Natural Science Foundation of China (Grant No: 81870549; 81900724).

Funding Information:
The authors thank all doctors, nurses and research staffs at the primary care hospitals, 6 district-level Women and Children's Health Center and Tianjin Women and Children's Health Center for their participation in this study. X.Y. & Z.F. conceived the idea and designed the study; J.Leng & W.L. collected the data; K.Y. & Z.F. conducted the measurement of ceramides and TMAO metabolites; J.Liu, J.Li & X.Y. analyzed the data; J.Liu, J.Li & X.Y. wrote the first draft; W.Y. X.H. Z.Y. R.C.M. & G.H. gave critical comments and edited the manuscript; All authors gave comments and contributed to the writing of the manuscript and agreed to submit and publish the manuscript. J.Liu & X.Y. took full responsibility for the work as a whole, including the study design, access to the data, and decision to submit.

Publisher Copyright:
© 2020 Elsevier B.V.

ASJC Scopus Subject Areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

PubMed: MeSH publication types

Journal Article

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10.1016/j.diabres.2020.108606

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Liu, J., Li, J., Yang, K., Leng, J., Li, W., Yang, W., Huo, X., Yu, Z., CW Ma, R., Hu, G., Fang, Z., & Yang, X. (2021). Ceramides and their interactive effects with trimethylamine-N-oxide metabolites on risk of gestational diabetes: A nested case-control study. Diabetes Research and Clinical Practice, 171, Artículo 108606. https://doi.org/10.1016/j.diabres.2020.108606

@article{1c0a0a73aadc41d5affbfb586390c81d,

title = "Ceramides and their interactive effects with trimethylamine-N-oxide metabolites on risk of gestational diabetes: A nested case-control study",

abstract = "Aims: To explore associations between ceramides in early pregnancy and gestational diabetes mellitus (GDM); and interactions between ceramides and trimethylamine N-oxide (TMAO) metabolites for GDM. Methods: We organized a 1:1 nested case-control study (n = 486) from a prospective cohort of pregnant women. Conditional logistic regression and additive interaction were performed to examine relationships between ceramides and TMAO metabolites for GDM. We defined trimethylamine (TMA) conversion ratio (TMAR) as TMA/its precursors and TMAO conversion ratio (TMAOR) as TMAO/TMA. Copresence of high TMAR and low TMAOR indicated TMA accumulation status. Results: High ceramides 18:0 (per SD), 18:1 (per SD) and low ceramide 24:0 (≤ 3.60 nmol/mL) were associated with increased GDM risk (OR: 1.69, 1.72 & 3.59, respectively). High TMA enhanced the OR of low ceramide 24:0 for GDM from 1.53 (95%CI: 0.88–2.66) to 10.3 (2.83–37.5), high TMAR enhanced it from 1.31 (0.67–2.56) to 24.3 (6.57–89.5) and TMA accumulation enhanced it from 1.42 (0.72–2.77) to 25.5 (6.80–95.7), with all additive interactions being significant. However, the interactions between high ceramide 18 and TMAO metabolites were not significant. Conclusions: High ceramides 18:0, 18:1 and low ceramide 24:0 in early pregnancy were associated with increased GDM risk. Notably, TMA accumulation greatly amplified the risk-promoting effect of low ceramide 24:0 for GDM.",

author = "Jinnan Liu and Jing Li and Kai Yang and Junhong Leng and Weiqin Li and Wen Yang and Xiaoxu Huo and Zhijie Yu and {CW Ma}, Ronald and Gang Hu and Zhongze Fang and Xilin Yang",

note = "Funding Information: This research was supported by the National Key Research and Development Program of China (Grant No: 2018YFC1313900; 2018YFC1313903; 2019YFA0802300; 2019YFA0802302) and the National Natural Science Foundation of China (Grant No: 81870549; 81900724). Funding Information: The authors thank all doctors, nurses and research staffs at the primary care hospitals, 6 district-level Women and Children's Health Center and Tianjin Women and Children's Health Center for their participation in this study. X.Y. & Z.F. conceived the idea and designed the study; J.Leng & W.L. collected the data; K.Y. & Z.F. conducted the measurement of ceramides and TMAO metabolites; J.Liu, J.Li & X.Y. analyzed the data; J.Liu, J.Li & X.Y. wrote the first draft; W.Y. X.H. Z.Y. R.C.M. & G.H. gave critical comments and edited the manuscript; All authors gave comments and contributed to the writing of the manuscript and agreed to submit and publish the manuscript. J.Liu & X.Y. took full responsibility for the work as a whole, including the study design, access to the data, and decision to submit. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2021",

month = jan,

doi = "10.1016/j.diabres.2020.108606",

language = "English",

volume = "171",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Ceramides and their interactive effects with trimethylamine-N-oxide metabolites on risk of gestational diabetes

T2 - A nested case-control study

AU - Liu, Jinnan

AU - Li, Jing

AU - Yang, Kai

AU - Leng, Junhong

AU - Li, Weiqin

AU - Yang, Wen

AU - Huo, Xiaoxu

AU - Yu, Zhijie

AU - CW Ma, Ronald

AU - Hu, Gang

AU - Fang, Zhongze

AU - Yang, Xilin

N1 - Funding Information: This research was supported by the National Key Research and Development Program of China (Grant No: 2018YFC1313900; 2018YFC1313903; 2019YFA0802300; 2019YFA0802302) and the National Natural Science Foundation of China (Grant No: 81870549; 81900724). Funding Information: The authors thank all doctors, nurses and research staffs at the primary care hospitals, 6 district-level Women and Children's Health Center and Tianjin Women and Children's Health Center for their participation in this study. X.Y. & Z.F. conceived the idea and designed the study; J.Leng & W.L. collected the data; K.Y. & Z.F. conducted the measurement of ceramides and TMAO metabolites; J.Liu, J.Li & X.Y. analyzed the data; J.Liu, J.Li & X.Y. wrote the first draft; W.Y. X.H. Z.Y. R.C.M. & G.H. gave critical comments and edited the manuscript; All authors gave comments and contributed to the writing of the manuscript and agreed to submit and publish the manuscript. J.Liu & X.Y. took full responsibility for the work as a whole, including the study design, access to the data, and decision to submit. Publisher Copyright: © 2020 Elsevier B.V.

PY - 2021/1

Y1 - 2021/1

N2 - Aims: To explore associations between ceramides in early pregnancy and gestational diabetes mellitus (GDM); and interactions between ceramides and trimethylamine N-oxide (TMAO) metabolites for GDM. Methods: We organized a 1:1 nested case-control study (n = 486) from a prospective cohort of pregnant women. Conditional logistic regression and additive interaction were performed to examine relationships between ceramides and TMAO metabolites for GDM. We defined trimethylamine (TMA) conversion ratio (TMAR) as TMA/its precursors and TMAO conversion ratio (TMAOR) as TMAO/TMA. Copresence of high TMAR and low TMAOR indicated TMA accumulation status. Results: High ceramides 18:0 (per SD), 18:1 (per SD) and low ceramide 24:0 (≤ 3.60 nmol/mL) were associated with increased GDM risk (OR: 1.69, 1.72 & 3.59, respectively). High TMA enhanced the OR of low ceramide 24:0 for GDM from 1.53 (95%CI: 0.88–2.66) to 10.3 (2.83–37.5), high TMAR enhanced it from 1.31 (0.67–2.56) to 24.3 (6.57–89.5) and TMA accumulation enhanced it from 1.42 (0.72–2.77) to 25.5 (6.80–95.7), with all additive interactions being significant. However, the interactions between high ceramide 18 and TMAO metabolites were not significant. Conclusions: High ceramides 18:0, 18:1 and low ceramide 24:0 in early pregnancy were associated with increased GDM risk. Notably, TMA accumulation greatly amplified the risk-promoting effect of low ceramide 24:0 for GDM.

AB - Aims: To explore associations between ceramides in early pregnancy and gestational diabetes mellitus (GDM); and interactions between ceramides and trimethylamine N-oxide (TMAO) metabolites for GDM. Methods: We organized a 1:1 nested case-control study (n = 486) from a prospective cohort of pregnant women. Conditional logistic regression and additive interaction were performed to examine relationships between ceramides and TMAO metabolites for GDM. We defined trimethylamine (TMA) conversion ratio (TMAR) as TMA/its precursors and TMAO conversion ratio (TMAOR) as TMAO/TMA. Copresence of high TMAR and low TMAOR indicated TMA accumulation status. Results: High ceramides 18:0 (per SD), 18:1 (per SD) and low ceramide 24:0 (≤ 3.60 nmol/mL) were associated with increased GDM risk (OR: 1.69, 1.72 & 3.59, respectively). High TMA enhanced the OR of low ceramide 24:0 for GDM from 1.53 (95%CI: 0.88–2.66) to 10.3 (2.83–37.5), high TMAR enhanced it from 1.31 (0.67–2.56) to 24.3 (6.57–89.5) and TMA accumulation enhanced it from 1.42 (0.72–2.77) to 25.5 (6.80–95.7), with all additive interactions being significant. However, the interactions between high ceramide 18 and TMAO metabolites were not significant. Conclusions: High ceramides 18:0, 18:1 and low ceramide 24:0 in early pregnancy were associated with increased GDM risk. Notably, TMA accumulation greatly amplified the risk-promoting effect of low ceramide 24:0 for GDM.

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JO - Diabetes Research and Clinical Practice

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ER -

Ceramides and their interactive effects with trimethylamine-N-oxide metabolites on risk of gestational diabetes: A nested case-control study

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Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

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