Changes in the brain-derived neurotrophic factor are associated with improvements in diabetes risk factors after exercise training in adolescents with obesity: The Hearty randomized controlled trial

Jeremy J. Walsh; Amedeo D'Angiulli; Jameason D. Cameron; Ronald J. Sigal; Glen P. Kenny; Martin Holcik; Steve Doucette; Angela S. Alberga; Denis Prud'homme; Stasia Hadjiyannakis; Katie Gunnell; Gary S. Goldfield

doi:10.1155/2018/7169583

Changes in the brain-derived neurotrophic factor are associated with improvements in diabetes risk factors after exercise training in adolescents with obesity: The Hearty randomized controlled trial

Jeremy J. Walsh, Amedeo D'Angiulli, Jameason D. Cameron, Ronald J. Sigal, Glen P. Kenny, Martin Holcik, Steve Doucette, Angela S. Alberga, Denis Prud'homme, Stasia Hadjiyannakis, Katie Gunnell, Gary S. Goldfield

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

23 Citas (Scopus)

Resumen

Obesity in youth increases the risk of type 2 diabetes (T2D), and both are risk factors for neurocognitive deficits. Exercise attenuates the risk of obesity and T2D while improving cognitive function. In adults, these benefits are associated with the actions of the brain-derived neurotrophic factor (BDNF), a protein critical in modulating neuroplasticity, glucose regulation, fat oxidation, and appetite regulation in adults. However, little research exists in youth. This study examined the associations between changes in diabetes risk factors and changes in BDNF levels after 6 months of exercise training in adolescents with obesity. The sample consisted of 202 postpubertal adolescents with obesity (70% females) aged 14-18 years who were randomized to 6 months of aerobic and/or resistance training or nonexercise control. All participants received a healthy eating plan designed to induce a 250/kcal deficit per day. Resting serum BDNF levels and diabetes risk factors, such as fasting glucose, insulin, homeostasis model assessment (HOMA-B-beta cell insulin secretory capacity) and (HOMA-IS-insulin sensitivity), and hemoglobin A1c (HbA1c), were measured after an overnight fast at baseline and 6 months. There were no significant intergroup differences on changes in BDNF or diabetes risk factors. In the exercise group, increases in BDNF were associated with reductions in fasting glucose (β = −6.57, SE = 3.37, p = 0 05) and increases in HOMA-B (β = 0.093, SE = 0.03, p = 0 004) after controlling for confounders. No associations were found between changes in diabetes risk factors and BDNF in controls. In conclusion, exercise-induced reductions in some diabetes risk factors were associated with increases in BDNF in adolescents with obesity, suggesting that exercise training may be an effective strategy to promote metabolic health and increases in BDNF, a protein favoring neuroplasticity. This trial is registered with ClinicalTrials.gov NCT00195858, September 12, 2005 (funded by the Canadian Institutes of Health Research).

Idioma original	English
Número de artículo	7169583
Publicación	Neural Plasticity
Volumen	2018
DOI	https://doi.org/10.1155/2018/7169583
Estado	Published - 2018

Nota bibliográfica

Funding Information:
The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research. Dr. Goldfield was supported by a New Investigator Award from the Canadian Institutes of Health Research for the part of this trial and subsequently by an Endowed Research Chair from the Children's Hospital of Eastern Ontario Volunteer Association Board. Dr. Sigal was supported by a Health Senior Scholar Award from the Alberta Innovates - Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. Dr. Kenny was supported by a University Research Chair from the University of Ottawa. Dr. Alberga was supported by a Doctoral Student Research Award from the Canadian Diabetes Association. We would like to thank the HEARTY trial participants, as well as Krista Hind, BSc. (deceased), Bruno Lemire, Ph.D., Marta Wein, BSc., Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD, Pascale Messier, BSc., RD, Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queen's University, Kingston, Ontario, Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D. (York University, Toronto, Ontario, Canada), and Yves Martel, Ph.D. (TomoVision, Magog, Quebec, Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ontario, Canada), RA Centre (Ottawa, Ontario, Canada), Children's Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Quebec, Canada) collaborated throughout the trial. We would like to thank Thet Naing for performing the BDNF analysis.

Funding Information:
The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research. Dr. Goldfield was supported by a New Investigator Award from the Canadian Institutes of Health Research for the part of this trial and subsequently by an Endowed Research Chair from the Children’s Hospital of Eastern Ontario Volunteer Association Board. Dr. Sigal was supported by a Health Senior Scholar Award from the Alberta Innovates - Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. Dr. Kenny was supported by a University Research Chair from the University of Ottawa. Dr. Alberga was supported by a Doctoral Student Research Award from the Canadian Diabetes Association. We would like to thank the HEARTY trial participants, as well as Krista Hind, BSc. (deceased), Bruno Lemire, Ph.D., Marta Wein, BSc., Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD, Pascale Messier, BSc., RD, Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queen’s University, Kingston, Ontario, Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D. (York University, Toronto, Ontario, Canada), and Yves Martel, Ph.D. (TomoVision, Magog, Quebec, Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ontario, Canada), RA Centre (Ottawa, Ontario, Canada), Children’s Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Quebec, Canada) collaborated throughout the trial. We would like to thank Thet Naing for performing the BDNF analysis.

Publisher Copyright:
© 2018 Jeremy J. Walsh et al.

ASJC Scopus Subject Areas

Neurology
Clinical Neurology

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.1155/2018/7169583

Otros archivos y enlaces

Citar esto

Walsh, J. J., D'Angiulli, A., Cameron, J. D., Sigal, R. J., Kenny, G. P., Holcik, M., Doucette, S., Alberga, A. S., Prud'homme, D., Hadjiyannakis, S., Gunnell, K., & Goldfield, G. S. (2018). Changes in the brain-derived neurotrophic factor are associated with improvements in diabetes risk factors after exercise training in adolescents with obesity: The Hearty randomized controlled trial. Neural Plasticity, 2018, Artículo 7169583. https://doi.org/10.1155/2018/7169583

Changes in the brain-derived neurotrophic factor are associated with improvements in diabetes risk factors after exercise training in adolescents with obesity: The Hearty randomized controlled trial. / Walsh, Jeremy J.; D'Angiulli, Amedeo; Cameron, Jameason D. et al.
En: Neural Plasticity, Vol. 2018, 7169583, 2018.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

Walsh, JJ, D'Angiulli, A, Cameron, JD, Sigal, RJ, Kenny, GP, Holcik, M, Doucette, S, Alberga, AS, Prud'homme, D, Hadjiyannakis, S, Gunnell, K & Goldfield, GS 2018, 'Changes in the brain-derived neurotrophic factor are associated with improvements in diabetes risk factors after exercise training in adolescents with obesity: The Hearty randomized controlled trial', Neural Plasticity, vol. 2018, 7169583. https://doi.org/10.1155/2018/7169583

@article{242b240973fa4461897048bff19812ff,

title = "Changes in the brain-derived neurotrophic factor are associated with improvements in diabetes risk factors after exercise training in adolescents with obesity: The Hearty randomized controlled trial",

abstract = "Obesity in youth increases the risk of type 2 diabetes (T2D), and both are risk factors for neurocognitive deficits. Exercise attenuates the risk of obesity and T2D while improving cognitive function. In adults, these benefits are associated with the actions of the brain-derived neurotrophic factor (BDNF), a protein critical in modulating neuroplasticity, glucose regulation, fat oxidation, and appetite regulation in adults. However, little research exists in youth. This study examined the associations between changes in diabetes risk factors and changes in BDNF levels after 6 months of exercise training in adolescents with obesity. The sample consisted of 202 postpubertal adolescents with obesity (70% females) aged 14-18 years who were randomized to 6 months of aerobic and/or resistance training or nonexercise control. All participants received a healthy eating plan designed to induce a 250/kcal deficit per day. Resting serum BDNF levels and diabetes risk factors, such as fasting glucose, insulin, homeostasis model assessment (HOMA-B-beta cell insulin secretory capacity) and (HOMA-IS-insulin sensitivity), and hemoglobin A1c (HbA1c), were measured after an overnight fast at baseline and 6 months. There were no significant intergroup differences on changes in BDNF or diabetes risk factors. In the exercise group, increases in BDNF were associated with reductions in fasting glucose (β = −6.57, SE = 3.37, p = 0 05) and increases in HOMA-B (β = 0.093, SE = 0.03, p = 0 004) after controlling for confounders. No associations were found between changes in diabetes risk factors and BDNF in controls. In conclusion, exercise-induced reductions in some diabetes risk factors were associated with increases in BDNF in adolescents with obesity, suggesting that exercise training may be an effective strategy to promote metabolic health and increases in BDNF, a protein favoring neuroplasticity. This trial is registered with ClinicalTrials.gov NCT00195858, September 12, 2005 (funded by the Canadian Institutes of Health Research).",

author = "Walsh, {Jeremy J.} and Amedeo D'Angiulli and Cameron, {Jameason D.} and Sigal, {Ronald J.} and Kenny, {Glen P.} and Martin Holcik and Steve Doucette and Alberga, {Angela S.} and Denis Prud'homme and Stasia Hadjiyannakis and Katie Gunnell and Goldfield, {Gary S.}",

note = "Funding Information: The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research. Dr. Goldfield was supported by a New Investigator Award from the Canadian Institutes of Health Research for the part of this trial and subsequently by an Endowed Research Chair from the Children's Hospital of Eastern Ontario Volunteer Association Board. Dr. Sigal was supported by a Health Senior Scholar Award from the Alberta Innovates - Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. Dr. Kenny was supported by a University Research Chair from the University of Ottawa. Dr. Alberga was supported by a Doctoral Student Research Award from the Canadian Diabetes Association. We would like to thank the HEARTY trial participants, as well as Krista Hind, BSc. (deceased), Bruno Lemire, Ph.D., Marta Wein, BSc., Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD, Pascale Messier, BSc., RD, Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queen's University, Kingston, Ontario, Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D. (York University, Toronto, Ontario, Canada), and Yves Martel, Ph.D. (TomoVision, Magog, Quebec, Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ontario, Canada), RA Centre (Ottawa, Ontario, Canada), Children's Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Quebec, Canada) collaborated throughout the trial. We would like to thank Thet Naing for performing the BDNF analysis. Funding Information: The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research. Dr. Goldfield was supported by a New Investigator Award from the Canadian Institutes of Health Research for the part of this trial and subsequently by an Endowed Research Chair from the Children{\textquoteright}s Hospital of Eastern Ontario Volunteer Association Board. Dr. Sigal was supported by a Health Senior Scholar Award from the Alberta Innovates - Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. Dr. Kenny was supported by a University Research Chair from the University of Ottawa. Dr. Alberga was supported by a Doctoral Student Research Award from the Canadian Diabetes Association. We would like to thank the HEARTY trial participants, as well as Krista Hind, BSc. (deceased), Bruno Lemire, Ph.D., Marta Wein, BSc., Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD, Pascale Messier, BSc., RD, Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queen{\textquoteright}s University, Kingston, Ontario, Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D. (York University, Toronto, Ontario, Canada), and Yves Martel, Ph.D. (TomoVision, Magog, Quebec, Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ontario, Canada), RA Centre (Ottawa, Ontario, Canada), Children{\textquoteright}s Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Quebec, Canada) collaborated throughout the trial. We would like to thank Thet Naing for performing the BDNF analysis. Publisher Copyright: {\textcopyright} 2018 Jeremy J. Walsh et al.",

year = "2018",

doi = "10.1155/2018/7169583",

language = "English",

volume = "2018",

journal = "Neural Plasticity",

issn = "2090-5904",

publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Changes in the brain-derived neurotrophic factor are associated with improvements in diabetes risk factors after exercise training in adolescents with obesity

T2 - The Hearty randomized controlled trial

AU - Walsh, Jeremy J.

AU - D'Angiulli, Amedeo

AU - Cameron, Jameason D.

AU - Sigal, Ronald J.

AU - Kenny, Glen P.

AU - Holcik, Martin

AU - Doucette, Steve

AU - Alberga, Angela S.

AU - Prud'homme, Denis

AU - Hadjiyannakis, Stasia

AU - Gunnell, Katie

AU - Goldfield, Gary S.

N1 - Funding Information: The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research. Dr. Goldfield was supported by a New Investigator Award from the Canadian Institutes of Health Research for the part of this trial and subsequently by an Endowed Research Chair from the Children's Hospital of Eastern Ontario Volunteer Association Board. Dr. Sigal was supported by a Health Senior Scholar Award from the Alberta Innovates - Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. Dr. Kenny was supported by a University Research Chair from the University of Ottawa. Dr. Alberga was supported by a Doctoral Student Research Award from the Canadian Diabetes Association. We would like to thank the HEARTY trial participants, as well as Krista Hind, BSc. (deceased), Bruno Lemire, Ph.D., Marta Wein, BSc., Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD, Pascale Messier, BSc., RD, Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queen's University, Kingston, Ontario, Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D. (York University, Toronto, Ontario, Canada), and Yves Martel, Ph.D. (TomoVision, Magog, Quebec, Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ontario, Canada), RA Centre (Ottawa, Ontario, Canada), Children's Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Quebec, Canada) collaborated throughout the trial. We would like to thank Thet Naing for performing the BDNF analysis. Funding Information: The HEARTY trial was supported by grant MCT-71979 from the Canadian Institutes of Health Research. Dr. Goldfield was supported by a New Investigator Award from the Canadian Institutes of Health Research for the part of this trial and subsequently by an Endowed Research Chair from the Children’s Hospital of Eastern Ontario Volunteer Association Board. Dr. Sigal was supported by a Health Senior Scholar Award from the Alberta Innovates - Health Solutions and previously supported by a Research Chair from the Ottawa Hospital Research Institute during part of this trial. Dr. Kenny was supported by a University Research Chair from the University of Ottawa. Dr. Alberga was supported by a Doctoral Student Research Award from the Canadian Diabetes Association. We would like to thank the HEARTY trial participants, as well as Krista Hind, BSc. (deceased), Bruno Lemire, Ph.D., Marta Wein, BSc., Kim Robertson, BSc., Kim Fetch, BSc., Brittany Hanlon, MHA, Jane Yardley, Ph.D., Nadia Balaa, BSc., Karen Lopez, BSc., Pamela Martino, MSc., Kim Morin, BSc., Colleen Gilchrist, BSc., RD, Pascale Messier, BSc., RD, Kelley Phillips, MA, and students in the School of Human Kinetics, University of Ottawa, who contributed to study coordination, exercise training, and evaluation of study participants. Robert Ross, Ph.D. (Queen’s University, Kingston, Ontario, Canada), Alison Bradshaw, MSc., and Jennifer Kuk, Ph.D. (York University, Toronto, Ontario, Canada), and Yves Martel, Ph.D. (TomoVision, Magog, Quebec, Canada) assisted with training and provided ongoing advice on body composition analysis. The Ottawa-Carleton Regional YMCA/YWCA (Ottawa, Ontario, Canada), RA Centre (Ottawa, Ontario, Canada), Children’s Hospital of Eastern Ontario, and Nautilus Plus and MRI Plus (both in Gatineau, Quebec, Canada) collaborated throughout the trial. We would like to thank Thet Naing for performing the BDNF analysis. Publisher Copyright: © 2018 Jeremy J. Walsh et al.

PY - 2018

Y1 - 2018

N2 - Obesity in youth increases the risk of type 2 diabetes (T2D), and both are risk factors for neurocognitive deficits. Exercise attenuates the risk of obesity and T2D while improving cognitive function. In adults, these benefits are associated with the actions of the brain-derived neurotrophic factor (BDNF), a protein critical in modulating neuroplasticity, glucose regulation, fat oxidation, and appetite regulation in adults. However, little research exists in youth. This study examined the associations between changes in diabetes risk factors and changes in BDNF levels after 6 months of exercise training in adolescents with obesity. The sample consisted of 202 postpubertal adolescents with obesity (70% females) aged 14-18 years who were randomized to 6 months of aerobic and/or resistance training or nonexercise control. All participants received a healthy eating plan designed to induce a 250/kcal deficit per day. Resting serum BDNF levels and diabetes risk factors, such as fasting glucose, insulin, homeostasis model assessment (HOMA-B-beta cell insulin secretory capacity) and (HOMA-IS-insulin sensitivity), and hemoglobin A1c (HbA1c), were measured after an overnight fast at baseline and 6 months. There were no significant intergroup differences on changes in BDNF or diabetes risk factors. In the exercise group, increases in BDNF were associated with reductions in fasting glucose (β = −6.57, SE = 3.37, p = 0 05) and increases in HOMA-B (β = 0.093, SE = 0.03, p = 0 004) after controlling for confounders. No associations were found between changes in diabetes risk factors and BDNF in controls. In conclusion, exercise-induced reductions in some diabetes risk factors were associated with increases in BDNF in adolescents with obesity, suggesting that exercise training may be an effective strategy to promote metabolic health and increases in BDNF, a protein favoring neuroplasticity. This trial is registered with ClinicalTrials.gov NCT00195858, September 12, 2005 (funded by the Canadian Institutes of Health Research).

AB - Obesity in youth increases the risk of type 2 diabetes (T2D), and both are risk factors for neurocognitive deficits. Exercise attenuates the risk of obesity and T2D while improving cognitive function. In adults, these benefits are associated with the actions of the brain-derived neurotrophic factor (BDNF), a protein critical in modulating neuroplasticity, glucose regulation, fat oxidation, and appetite regulation in adults. However, little research exists in youth. This study examined the associations between changes in diabetes risk factors and changes in BDNF levels after 6 months of exercise training in adolescents with obesity. The sample consisted of 202 postpubertal adolescents with obesity (70% females) aged 14-18 years who were randomized to 6 months of aerobic and/or resistance training or nonexercise control. All participants received a healthy eating plan designed to induce a 250/kcal deficit per day. Resting serum BDNF levels and diabetes risk factors, such as fasting glucose, insulin, homeostasis model assessment (HOMA-B-beta cell insulin secretory capacity) and (HOMA-IS-insulin sensitivity), and hemoglobin A1c (HbA1c), were measured after an overnight fast at baseline and 6 months. There were no significant intergroup differences on changes in BDNF or diabetes risk factors. In the exercise group, increases in BDNF were associated with reductions in fasting glucose (β = −6.57, SE = 3.37, p = 0 05) and increases in HOMA-B (β = 0.093, SE = 0.03, p = 0 004) after controlling for confounders. No associations were found between changes in diabetes risk factors and BDNF in controls. In conclusion, exercise-induced reductions in some diabetes risk factors were associated with increases in BDNF in adolescents with obesity, suggesting that exercise training may be an effective strategy to promote metabolic health and increases in BDNF, a protein favoring neuroplasticity. This trial is registered with ClinicalTrials.gov NCT00195858, September 12, 2005 (funded by the Canadian Institutes of Health Research).

UR - http://www.scopus.com/inward/record.url?scp=85055612809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055612809&partnerID=8YFLogxK

U2 - 10.1155/2018/7169583

DO - 10.1155/2018/7169583

M3 - Article

C2 - 30363954

AN - SCOPUS:85055612809

SN - 2090-5904

VL - 2018

JO - Neural Plasticity

JF - Neural Plasticity

M1 - 7169583

ER -

Changes in the brain-derived neurotrophic factor are associated with improvements in diabetes risk factors after exercise training in adolescents with obesity: The Hearty randomized controlled trial

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto