Changes with age in the distribution of a frailty index

Kenneth Rockwood; Alexander Mogilner; Arnold Mitnitski

doi:10.1016/j.mad.2004.05.003

Changes with age in the distribution of a frailty index

Kenneth Rockwood, Alexander Mogilner, Arnold Mitnitski

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142 Citas (Scopus)

Resumen

Models of human mortality include a factor that summarises intrinsic differences in individual rates of ageing, commonly called frailty. Frailty also describes a clinical syndrome of apparent vulnerability. In a representative, cross-sectional, Canadian survey (n = 66,589) we calculated a frailty index as the mean accumulation of deficits and previously showed it to increase exponentially with age. Here, its density function exhibited a monotonic change in shape, being least skewed at the oldest ages. Although the shape gradually changed, the frailty index was well fitted by a gamma distribution. Of note, the variation coefficient, initially high, decreased from middle age on. Being able to quantify frailty means that health risks can be summarised at both the individual and group levels.

Idioma original	English
Páginas (desde-hasta)	517-519
Número de páginas	3
Publicación	Mechanisms of Ageing and Development
Volumen	125
N.º	7
DOI	https://doi.org/10.1016/j.mad.2004.05.003
Estado	Published - jul. 2004

Nota bibliográfica

Funding Information:
This analysis was funded by Health Canada through the National Health Research and Development Program, Grant 6603-1548-NPHS and by the Canadian Institutes of Health Research (CIHR) grant 40922. Kenneth Rockwood is supported by an Investigator Award from the CIHR and by the Dalhousie Medical Research Foundation as the Kathryn Allen Weldon Professor of Alzheimer Research.

ASJC Scopus Subject Areas

Ageing
Developmental Biology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODS de las Naciones Unidas

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title = "Changes with age in the distribution of a frailty index",

abstract = "Models of human mortality include a factor that summarises intrinsic differences in individual rates of ageing, commonly called frailty. Frailty also describes a clinical syndrome of apparent vulnerability. In a representative, cross-sectional, Canadian survey (n = 66,589) we calculated a frailty index as the mean accumulation of deficits and previously showed it to increase exponentially with age. Here, its density function exhibited a monotonic change in shape, being least skewed at the oldest ages. Although the shape gradually changed, the frailty index was well fitted by a gamma distribution. Of note, the variation coefficient, initially high, decreased from middle age on. Being able to quantify frailty means that health risks can be summarised at both the individual and group levels.",

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Changes with age in the distribution of a frailty index

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

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