Coexpression and regulation of the FGF-2 and FGF antisense genes in leukemic cells

Mark Baguma-Nibasheka; Audrey W. Li; Mohammed S. Osman; Laurette Geldenhuys; Alan G. Casson; Catherine K.L. Too; Paul R. Murphy

doi:10.1016/j.leukres.2004.09.006

Coexpression and regulation of the FGF-2 and FGF antisense genes in leukemic cells

Mark Baguma-Nibasheka, Audrey W. Li, Mohammed S. Osman, Laurette Geldenhuys, Alan G. Casson, Catherine K.L. Too, Paul R. Murphy

Medicine

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

24 Citas (Scopus)

Resumen

Fibroblast growth factor-2 (FGF-2) is a growth and survival factor whose expression is elevated in many hematopoietic malignancies. A natural antisense RNA (FGF-AS) has been implicated in the posttranscriptional regulation of FGF-2 mRNA expression. We demonstrate for the first time that FGF sense and antisense RNAs are coordinately expressed and translated in hematopoietic cells and tissues. Cytokine stimulation of growth-arrested K562 cells elicited a rapid transient increase in FGF-AS mRNA expression followed by a slower but sustained increase in FGF-2 mRNA. This was accompanied by a marked increase in the expression and nuclear translocation of FGF-2 and the FGF-AS encoded protein, GFG/NUDT6. These findings suggest a role for both FGF-2 and GFG proteins in the cell survival and proliferation of lymphoid and myeloid tumor cells.

Idioma original	English
Páginas (desde-hasta)	423-433
Número de páginas	11
Publicación	Leukemia Research
Volumen	29
N.º	4
DOI	https://doi.org/10.1016/j.leukres.2004.09.006
Estado	Published - abr. 2005

Nota bibliográfica

Funding Information:
We thank Cancer Care Nova Scotia and the Nova Scotia Health Research Foundation for post-doctoral fellowship support to M. Baguma-Nibasheka and two summer studentships to M.S. Osman. We also wish to thank Zuoyu Zheng, MD for expert immunohistochemical studies on human tissues. This study was funded by grants from the Canadian Institutes of Health and the Cancer Research Society Inc.

ASJC Scopus Subject Areas

Hematology
Oncology
Cancer Research

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODS de las Naciones Unidas

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title = "Coexpression and regulation of the FGF-2 and FGF antisense genes in leukemic cells",

abstract = "Fibroblast growth factor-2 (FGF-2) is a growth and survival factor whose expression is elevated in many hematopoietic malignancies. A natural antisense RNA (FGF-AS) has been implicated in the posttranscriptional regulation of FGF-2 mRNA expression. We demonstrate for the first time that FGF sense and antisense RNAs are coordinately expressed and translated in hematopoietic cells and tissues. Cytokine stimulation of growth-arrested K562 cells elicited a rapid transient increase in FGF-AS mRNA expression followed by a slower but sustained increase in FGF-2 mRNA. This was accompanied by a marked increase in the expression and nuclear translocation of FGF-2 and the FGF-AS encoded protein, GFG/NUDT6. These findings suggest a role for both FGF-2 and GFG proteins in the cell survival and proliferation of lymphoid and myeloid tumor cells.",

author = "Mark Baguma-Nibasheka and Li, {Audrey W.} and Osman, {Mohammed S.} and Laurette Geldenhuys and Casson, {Alan G.} and Too, {Catherine K.L.} and Murphy, {Paul R.}",

note = "Funding Information: We thank Cancer Care Nova Scotia and the Nova Scotia Health Research Foundation for post-doctoral fellowship support to M. Baguma-Nibasheka and two summer studentships to M.S. Osman. We also wish to thank Zuoyu Zheng, MD for expert immunohistochemical studies on human tissues. This study was funded by grants from the Canadian Institutes of Health and the Cancer Research Society Inc.",

year = "2005",

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doi = "10.1016/j.leukres.2004.09.006",

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AU - Baguma-Nibasheka, Mark

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AU - Osman, Mohammed S.

AU - Geldenhuys, Laurette

AU - Casson, Alan G.

AU - Too, Catherine K.L.

AU - Murphy, Paul R.

N1 - Funding Information: We thank Cancer Care Nova Scotia and the Nova Scotia Health Research Foundation for post-doctoral fellowship support to M. Baguma-Nibasheka and two summer studentships to M.S. Osman. We also wish to thank Zuoyu Zheng, MD for expert immunohistochemical studies on human tissues. This study was funded by grants from the Canadian Institutes of Health and the Cancer Research Society Inc.

PY - 2005/4

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N2 - Fibroblast growth factor-2 (FGF-2) is a growth and survival factor whose expression is elevated in many hematopoietic malignancies. A natural antisense RNA (FGF-AS) has been implicated in the posttranscriptional regulation of FGF-2 mRNA expression. We demonstrate for the first time that FGF sense and antisense RNAs are coordinately expressed and translated in hematopoietic cells and tissues. Cytokine stimulation of growth-arrested K562 cells elicited a rapid transient increase in FGF-AS mRNA expression followed by a slower but sustained increase in FGF-2 mRNA. This was accompanied by a marked increase in the expression and nuclear translocation of FGF-2 and the FGF-AS encoded protein, GFG/NUDT6. These findings suggest a role for both FGF-2 and GFG proteins in the cell survival and proliferation of lymphoid and myeloid tumor cells.

AB - Fibroblast growth factor-2 (FGF-2) is a growth and survival factor whose expression is elevated in many hematopoietic malignancies. A natural antisense RNA (FGF-AS) has been implicated in the posttranscriptional regulation of FGF-2 mRNA expression. We demonstrate for the first time that FGF sense and antisense RNAs are coordinately expressed and translated in hematopoietic cells and tissues. Cytokine stimulation of growth-arrested K562 cells elicited a rapid transient increase in FGF-AS mRNA expression followed by a slower but sustained increase in FGF-2 mRNA. This was accompanied by a marked increase in the expression and nuclear translocation of FGF-2 and the FGF-AS encoded protein, GFG/NUDT6. These findings suggest a role for both FGF-2 and GFG proteins in the cell survival and proliferation of lymphoid and myeloid tumor cells.

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Coexpression and regulation of the FGF-2 and FGF antisense genes in leukemic cells

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

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