TY - JOUR
T1 - Complicated hospitalization due to influenza
T2 - Results from the Global Hospital Influenza Network for the 2017-2018 season
AU - Lina, Bruno
AU - Georges, Alexandre
AU - Burtseva, Elena
AU - Nunes, Marta C.
AU - Andrew, Melissa K.
AU - McNeil, Shelly A.
AU - Ruiz-Palacios, Guillermo M.
AU - Feng, Luzhao
AU - Kyncl, Jan
AU - Vanhems, Philippe
AU - Ortiz, Justin R.
AU - Paget, John
AU - Reiner, Robert C.
AU - Amour, Sélilah
AU - N'Gattia, Coulibaly Anderson
AU - Moreno, Victor Baselga
AU - Baumeister, Elsa
AU - Khelil, Jalila Ben
AU - Danilenko, Daria
AU - Diez-Domingo, Javier
AU - Drǎgǎnescu, Anca Cristina
AU - Emukule, Gideon O.
AU - Gauhar, Zhetpisbayeva
AU - Guerrero, M. Lourdes
AU - Mira-Iglesias, Ainara
AU - Kisteneva, Lidija
AU - Koul, Parvaiz A.
AU - Kuatbaeva, Ainagul
AU - Torres, Victor Alberto Laguna
AU - Launay, Odile
AU - Lenzi, Nezha
AU - Madhi, Shabir
AU - Mandakova, Zdenka
AU - Medić, Snežana
AU - Ristić, Mioljub
AU - Mir, Hyder
AU - Nitsch-Osuch, Aneta
AU - Otieno, Nancy
AU - Piţigoi, Daniela
AU - Pontoriero, Andrea
AU - Ramirez, Estela
AU - Salah, Ben
AU - Sandulescu, Oana
AU - Serafin, Natali
AU - Shan, Wei
AU - Sominina, Anna
AU - Trushakova, Svetlana
AU - Zalewski, Andrzej
AU - Zhang, Tao
N1 - Funding Information:
J.P. received research funds from the Foundation for Influenza Epidemiology for work related to this study and unrestricted research grants for work unrelated to the current study from Sanofi Pasteur (which provides financial support for the Foundation for Influenza Epidemiology). P.V. and M.N. received research funds from the Foundation for Influenza Epidemiology for work related to this study and personal fees from Sanofi Pasteur for work unrelated to the current study. M.K.A. and S.A.M. received research funds from the Foundation for Influenza Epidemiology for work related to this study and grants and personal fees from Sanofi Pasteur for work unrelated to the current study. J.K. received research funds from the Foundation for Influenza Epidemiology for work related to this study. A.G. was an employee of OpenHealth, which is paid by the Foundation for Influenza Epidemiology for work related to this study. All other authors declare no conflicts of interest.
Publisher Copyright:
© 2020 The Author(s).
PY - 2020/7/2
Y1 - 2020/7/2
N2 - Background: Since 2011, the Global Influenza Hospital Surveillance Network (GIHSN) has used active surveillance to prospectively collect epidemiological and virological data on patients hospitalized with influenza virus infection. Here, we describe influenza virus strain circulation in the GIHSN participant countries during 2017-2018 season and examine factors associated with complicated hospitalization among patients admitted with laboratory-confirmed influenza illness. Methods: The study enrolled patients who were hospitalized in a GIHSN hospital in the previous 48 h with acute respiratory symptoms and who had symptoms consistent with influenza within the 7 days before admission. Enrolled patients were tested by reverse transcription-polymerase chain reaction to confirm influenza virus infection. "Complicated hospitalization"was defined as a need for mechanical ventilation, admission to an intensive care unit, or in-hospital death. In each of four age strata (< 15, 15-< 50, 50-< 65, and ≥ 65 years), factors associated with complicated hospitalization in influenza-positive patients were identified by mixed effects logistic regression and those associated with length of hospital stay using a linear mixed-effects regression model. Results: The study included 12,803 hospitalized patients at 14 coordinating sites in 13 countries, of which 4306 (34%) tested positive for influenza. Influenza viruses B/Yamagata, A/H3N2, and A/H1N1pdm09 strains dominated and cocirculated, although the dominant strains varied between sites. Complicated hospitalization occurred in 10.6% of influenza-positive patients. Factors associated with complicated hospitalization in influenza-positive patients included chronic obstructive pulmonary disease (15-< 50 years and ≥ 65 years), diabetes (15-< 50 years), male sex (50-< 65 years), hospitalization during the last 12 months (50-< 65 years), and current smoking (≥65 years). Chronic obstructive pulmonary disease (50-< 65 years), other chronic conditions (15-< 50 years), influenza A (50-< 65 years), and hospitalization during the last 12 months (< 15 years) were associated with a longer hospital stay. The proportion of patients with complicated influenza did not differ between influenza A and B. Conclusions: Complicated hospitalizations occurred in over 10% of patients hospitalized with influenza virus infection. Factors commonly associated with complicated or longer hospitalization differed by age group but commonly included chronic obstructive pulmonary disease, diabetes, and hospitalization during the last 12 months.
AB - Background: Since 2011, the Global Influenza Hospital Surveillance Network (GIHSN) has used active surveillance to prospectively collect epidemiological and virological data on patients hospitalized with influenza virus infection. Here, we describe influenza virus strain circulation in the GIHSN participant countries during 2017-2018 season and examine factors associated with complicated hospitalization among patients admitted with laboratory-confirmed influenza illness. Methods: The study enrolled patients who were hospitalized in a GIHSN hospital in the previous 48 h with acute respiratory symptoms and who had symptoms consistent with influenza within the 7 days before admission. Enrolled patients were tested by reverse transcription-polymerase chain reaction to confirm influenza virus infection. "Complicated hospitalization"was defined as a need for mechanical ventilation, admission to an intensive care unit, or in-hospital death. In each of four age strata (< 15, 15-< 50, 50-< 65, and ≥ 65 years), factors associated with complicated hospitalization in influenza-positive patients were identified by mixed effects logistic regression and those associated with length of hospital stay using a linear mixed-effects regression model. Results: The study included 12,803 hospitalized patients at 14 coordinating sites in 13 countries, of which 4306 (34%) tested positive for influenza. Influenza viruses B/Yamagata, A/H3N2, and A/H1N1pdm09 strains dominated and cocirculated, although the dominant strains varied between sites. Complicated hospitalization occurred in 10.6% of influenza-positive patients. Factors associated with complicated hospitalization in influenza-positive patients included chronic obstructive pulmonary disease (15-< 50 years and ≥ 65 years), diabetes (15-< 50 years), male sex (50-< 65 years), hospitalization during the last 12 months (50-< 65 years), and current smoking (≥65 years). Chronic obstructive pulmonary disease (50-< 65 years), other chronic conditions (15-< 50 years), influenza A (50-< 65 years), and hospitalization during the last 12 months (< 15 years) were associated with a longer hospital stay. The proportion of patients with complicated influenza did not differ between influenza A and B. Conclusions: Complicated hospitalizations occurred in over 10% of patients hospitalized with influenza virus infection. Factors commonly associated with complicated or longer hospitalization differed by age group but commonly included chronic obstructive pulmonary disease, diabetes, and hospitalization during the last 12 months.
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U2 - 10.1186/s12879-020-05167-4
DO - 10.1186/s12879-020-05167-4
M3 - Article
C2 - 32615985
AN - SCOPUS:85087474353
SN - 1471-2334
VL - 20
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
IS - 1
M1 - 465
ER -