Corticolimbic anatomical characteristics predetermine risk for chronic pain

Etienne Vachon-Presseau, Pascal Tétreault, Bogdan Petre, Lejian Huang, Sara E. Berger, Souraya Torbey, Alexis T. Baria, Ali R. Mansour, Javeria A. Hashmi, James W. Griffith, Erika Comasco, Thomas J. Schnitzer, Marwan N. Baliki, A. Vania Apkarian

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

286 Citas (Scopus)

Resumen

See Tracey (doi:10.1093/brain/aww147) for a scientific commentary on this article. Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute back pain patients longitudinally for 3 years as they either recovered from or transitioned to chronic pain. Whole-brain comparisons indicated corticolimbic, but not pain-related circuitry, white matter connections predisposed patients to chronic pain. Intra-corticolimbic white matter connectivity analysis identified three segregated communities: dorsal medial prefrontal cortex-amygdala-accumbens, ventral medial prefrontal cortex-amygdala, and orbitofrontal cortex-amygdala-hippocampus. Higher incidence of white matter and functional connections within the dorsal medial prefrontal cortex-amygdala-accumbens circuit, as well as smaller amygdala volume, represented independent risk factors, together accounting for 60% of the variance for pain persistence. Opioid gene polymorphisms and negative mood contributed indirectly through corticolimbic anatomical factors, to risk for chronic pain. Our results imply that persistence of chronic pain is predetermined by corticolimbic neuroanatomical factors.

Idioma originalEnglish
Páginas (desde-hasta)1958-1970
Número de páginas13
PublicaciónBrain
Volumen139
N.º7
DOI
EstadoPublished - jul. 1 2016

Nota bibliográfica

Funding Information:
This work was supported by funds from the National Institute of Neurological Disorders and Stroke (NS035115, A.V.A.). E.V.P. and P.T. were funded from Canadian Institutes of Health Research (CIHR), E.C. was funded from Swedish Council for Working Life and Social Research (FAS: 2011-0627) and Uppsala University. M.N.B. was partially funded by an anonymous foundation.

Publisher Copyright:
© 2016 The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.

ASJC Scopus Subject Areas

  • Clinical Neurology

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