Decreases in behavioral and striatal neuronal responses to dexamphetamine with aging

Marcus W. Warenycia, Gerald M. McKenzie

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

5 Citas (Scopus)

Resumen

Striatal neurons of mature rats responded to 2.5 mg/kg dexamphetamine with increased multiple unit activity that followed the time course of drug-increased behavior. in contrast, In older (middle-aged) rats striatal neurons failed to respond to dexamphetamine with excitation. Behavioral responses were reduced by half as compared to mature rats. Retesting of these middle-aged rats with dexamphetamine did not result in either improved behavioral or neuronal responses and decreases in spontaneous MUA suggested dexamphetamine neurotoxicity in older animals. Since striatal neuronal responses and behavioral responses to dexamphetamine are greatly reduced, age-related impairment of dopaminergic neurotransmission may lead to in reductions in striatal neuronal excitation as well as feedback from dexamphetamine-induced behavior.

Idioma originalEnglish
Páginas (desde-hasta)489-491
Número de páginas3
PublicaciónPharmacology, Biochemistry and Behavior
Volumen33
N.º2
DOI
EstadoPublished - jun. 1989

ASJC Scopus Subject Areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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