Dietary linoleic acid is required for development of experimentally induced alcoholic liver injury

Amin A. Nanji, Samuel W. French

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

143 Citas (Scopus)

Resumen

We had previously hypothesized that linoleic acid (LA) was essential for development of alcoholic induced liver injury in our rat model. Male Wistar rats were fed a nutritionally adequate diet (25% calories as fat) with ethanol (8-17 g/kg/day). The source of fat was tallow (0.7% LA), lard (2.5% LA) or tallow supplemented with linoleic acid (2.5%). Liver damage was followed monthly by obtaining blood for alanine aminotransferase assay and liver biopsy for assessment of morphologic changes. Enzyme and histologic changes (fatty liver, necrosis and inflammation) in the tallow-linoleic acid-ethanol fed animals were more severe than in the lard-ethanol group. The tallow ethanol group did not show any evidence of liver injury. Our results strongly support our hypothesis that LA is essential for development of alcoholic liver disease in our rat model.

Idioma originalEnglish
Páginas (desde-hasta)223-227
Número de páginas5
PublicaciónLife Sciences
Volumen44
N.º3
DOI
EstadoPublished - 1989
Publicado de forma externa

Nota bibliográfica

Funding Information:
Technical assistance was provided by Linda Jui and Lee Anne Stefani. This study was supported by grants from the Ottawa General Hospital Research Foundation and Medical Research Council of Canada.

ASJC Scopus Subject Areas

  • General Biochemistry,Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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