Differences in fracture prevalence and in bone mineral density between Chinese and White Canadians: the Canadian Multicentre Osteoporosis Study (CaMos)

for the CaMOS Research Group

doi:10.1007/s11657-020-00822-4

Differences in fracture prevalence and in bone mineral density between Chinese and White Canadians: the Canadian Multicentre Osteoporosis Study (CaMos)

for the CaMOS Research Group

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

24 Citas (Scopus)

Resumen

Summary: Fracture determinants differ between Canadians of Chinese and White descent, the former constituting the second largest visible minority group in Canada. The results of this study support the importance of characterizing bone health predictors in Canadians of different ethnicity to improve population-specific fracture prevention and treatment strategies. Purpose: We aimed to compare clinical risk factors, bone mineral density, prevalence of osteoporosis, and fractures between Chinese and White Canadians to identify ethnicity-specific risks. Methods: We studied 236 Chinese and 8945 White Canadians aged 25+ years from the Canadian Multicentre Osteoporosis Study (CaMos). The prevalence of osteoporosis using ethnicity-specific peak bone mass (PBM), and of prior and incident low trauma fractures were assessed and compared between groups. Linear regressions, adjusting for age and anthropometric measures, were used to examine the association between baseline and 5-year changes in BMD and ethnicity. Results: Chinese participants had shorter stature, lower BMI, and lower rate of falls than White participants. Adjusted models showed no significant differences in baseline BMD between ethnic groups except in younger men where total hip BMD was 0.059 g/cm² (0.009; 0.108) lower in Chinese. Adjusted 5-year BMD change at lumbar spine was higher in older Chinese women and men compared with Whites. When using Chinese-specific PBM, the prevalence of osteoporosis in Chinese women was 2-fold lower than when using that of White women The prevalence of fractures was higher in White women compared with Chinese with differences up to 14.5% (95% CI 9.2; 19.7) and 10.5% (95% CI 4.5–16.4) in older White men. Incident fractures were rare in young Chinese compared with White participants and not different in the older groups. Conclusion: Our results support the importance of characterizing bone strength predictors in Chinese Canadians and the development of ethnicity-specific fracture prediction and prevention strategies.

Idioma original	English
Número de artículo	147
Publicación	Archives of Osteoporosis
Volumen	15
N.º	1
DOI	https://doi.org/10.1007/s11657-020-00822-4
Estado	Published - dic. 1 2020

Nota bibliográfica

Funding Information:
The Canadian Multicentre Osteoporosis Study (CaMos) was funded by the Canadian Institutes of Health Research (CIHR); Amgen Canada Inc; Actavis Pharma Inc (previously Warner Chilcott Canada Co); Dairy Farmers of Canada; Eli Lilly Canada Inc: Eli Lilly and Company; GE Lunar; Hologic Inc; Merck Frosst Canada Ltd; Novartis Pharmaceuticals Canada Inc; P&G Pharmaceuticals Canada Inc; Pfizer Canada Inc; Roche (F. Hoffmann-La Roche Ltd); Sanofi-Aventis Canada Inc (previously Aventis Pharma Inc); Servier Canada Inc; and The Arthritis Society.

Funding Information:
The authors wish to thank CaMos participants. The Canadian Multicentre Osteoporosis Study (CaMos) was funded by the Canadian Institutes of Health Research (CIHR); Amgen Canada Inc; Actavis Pharma Inc (previously Warner Chilcott Canada Co); Dairy Farmers of Canada; Eli Lilly Canada Inc: Eli Lilly and Company; GE Lunar; Hologic Inc; Merck Frosst Canada Ltd; Novartis Pharmaceuticals Canada Inc; P&G Pharmaceuticals Canada Inc; Pfizer Canada Inc; Roche (F. Hoffmann-La Roche Ltd); Sanofi-Aventis Canada Inc (previously Aventis Pharma Inc); Servier Canada Inc; and The Arthritis Society. The CaMos Research Group David Goltzman (co-principal investigator, McGill University), Nancy Kreiger (co-principal investigator, University of Toronto), Alan Tenenhouse (principal investigator emeritus, Toronto). McGill University, Montreal, Quebec: Elham Rahme (biostatistician), J. Brent Richards (investigator), Suzanne N. Morin (investigator); Claudie Berger (study statistician) Memorial University, St. John?s Newfoundland: Carol Joyce (director), Christopher S. Kovacs (co-director). Dalhousie University, Halifax, Nova Scotia: Susan Kirkland, Stephanie M. Kaiser (co-directors). Laval University, Quebec City, Quebec: Jacques P. Brown (director), Louis Bessette (co-director), GRMO. Queen?s University, Kingston, Ontario: Tassos P. Anastassiades (director), Tanveer Towheed (co-director), Wilma M. Hopman (investigator). University of Toronto, Toronto, Ontario: Angela M. Cheung (director), Robert G. Josse (co-director), Andy Kin On Wong (co-director). McMaster University, Hamilton, Ontario: Jonathan D. Adachi (director), Alexandra Papaioannou (co-director). University of Saskatchewan, Saskatoon, Saskatchewan: Wojciech P. Olszynski (director), K. Shawn Davison (co-director). University of Calgary, Calgary, Alberta: David A. Hanley (director), Steven K. Boyd (co-director). University of British Columbia, Vancouver, British Columbia: Jerilynn C. Prior (director), Shirin Kalyan (co-director), Brian Lentle (investigator/radiologist), Millan S. Patel (investigator). University of Alberta, Edmonton, Alberta: Stuart D. Jackson (medical physicist). University of Manitoba, Winnipeg, Manitoba: William D. Leslie (investigator/nuclear medicine physician). SNM is a scholar of the Fonds de Recherche du Qu?bec en sant?. AM Cheung holds a Tier 1 Canada Research Chair in Musculoskeletal and Postmenopausal Health.

Publisher Copyright:
© 2020, International Osteoporosis Foundation and National Osteoporosis Foundation.

ASJC Scopus Subject Areas

Orthopedics and Sports Medicine

Acceder al documento

10.1007/s11657-020-00822-4

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@article{e74a85db4b8547d68979e3f7fcd8b023,

title = "Differences in fracture prevalence and in bone mineral density between Chinese and White Canadians: the Canadian Multicentre Osteoporosis Study (CaMos)",

abstract = "Summary: Fracture determinants differ between Canadians of Chinese and White descent, the former constituting the second largest visible minority group in Canada. The results of this study support the importance of characterizing bone health predictors in Canadians of different ethnicity to improve population-specific fracture prevention and treatment strategies. Purpose: We aimed to compare clinical risk factors, bone mineral density, prevalence of osteoporosis, and fractures between Chinese and White Canadians to identify ethnicity-specific risks. Methods: We studied 236 Chinese and 8945 White Canadians aged 25+ years from the Canadian Multicentre Osteoporosis Study (CaMos). The prevalence of osteoporosis using ethnicity-specific peak bone mass (PBM), and of prior and incident low trauma fractures were assessed and compared between groups. Linear regressions, adjusting for age and anthropometric measures, were used to examine the association between baseline and 5-year changes in BMD and ethnicity. Results: Chinese participants had shorter stature, lower BMI, and lower rate of falls than White participants. Adjusted models showed no significant differences in baseline BMD between ethnic groups except in younger men where total hip BMD was 0.059 g/cm2 (0.009; 0.108) lower in Chinese. Adjusted 5-year BMD change at lumbar spine was higher in older Chinese women and men compared with Whites. When using Chinese-specific PBM, the prevalence of osteoporosis in Chinese women was 2-fold lower than when using that of White women The prevalence of fractures was higher in White women compared with Chinese with differences up to 14.5% (95% CI 9.2; 19.7) and 10.5% (95% CI 4.5–16.4) in older White men. Incident fractures were rare in young Chinese compared with White participants and not different in the older groups. Conclusion: Our results support the importance of characterizing bone strength predictors in Chinese Canadians and the development of ethnicity-specific fracture prediction and prevention strategies.",

author = "{for the CaMOS Research Group} and Morin, {S. N.} and C. Berger and W. Liu and Prior, {J. C.} and Cheung, {A. M.} and Hanley, {D. A.} and Boyd, {S. K.} and Wong, {A. K.O.} and A. Papaioannou and E. Rahme and D. Goltzman and Nancy Kreiger and Alan Tenenhouse and Elham Rahme and Richards, {J. Brent} and Claudie Berger and Carol Joyce and Kovacs, {Christopher S.} and Susan Kirkland and Kaiser, {Stephanie M.} and Brown, {Jacques P.} and Louis Bessette and Anastassiades, {Tassos P.} and Tanveer Towheed and Hopman, {Wilma M.} and Cheung, {Angela M.} and Josse, {Robert G.} and Wong, {Andy Kin On} and Adachi, {Jonathan D.} and Alexandra Papaioannou and Olszynski, {Wojciech P.} and Davison, {K. Shawn} and Hanley, {David A.} and Boyd, {Steven K.} and Prior, {Jerilynn C.} and Shirin Kalyan and Brian Lentle and Patel, {Millan S.} and Jackson, {Stuart D.} and Leslie, {William D.}",

note = "Funding Information: The Canadian Multicentre Osteoporosis Study (CaMos) was funded by the Canadian Institutes of Health Research (CIHR); Amgen Canada Inc; Actavis Pharma Inc (previously Warner Chilcott Canada Co); Dairy Farmers of Canada; Eli Lilly Canada Inc: Eli Lilly and Company; GE Lunar; Hologic Inc; Merck Frosst Canada Ltd; Novartis Pharmaceuticals Canada Inc; P&G Pharmaceuticals Canada Inc; Pfizer Canada Inc; Roche (F. Hoffmann-La Roche Ltd); Sanofi-Aventis Canada Inc (previously Aventis Pharma Inc); Servier Canada Inc; and The Arthritis Society. Funding Information: The authors wish to thank CaMos participants. The Canadian Multicentre Osteoporosis Study (CaMos) was funded by the Canadian Institutes of Health Research (CIHR); Amgen Canada Inc; Actavis Pharma Inc (previously Warner Chilcott Canada Co); Dairy Farmers of Canada; Eli Lilly Canada Inc: Eli Lilly and Company; GE Lunar; Hologic Inc; Merck Frosst Canada Ltd; Novartis Pharmaceuticals Canada Inc; P&G Pharmaceuticals Canada Inc; Pfizer Canada Inc; Roche (F. Hoffmann-La Roche Ltd); Sanofi-Aventis Canada Inc (previously Aventis Pharma Inc); Servier Canada Inc; and The Arthritis Society. The CaMos Research Group David Goltzman (co-principal investigator, McGill University), Nancy Kreiger (co-principal investigator, University of Toronto), Alan Tenenhouse (principal investigator emeritus, Toronto). McGill University, Montreal, Quebec: Elham Rahme (biostatistician), J. Brent Richards (investigator), Suzanne N. Morin (investigator); Claudie Berger (study statistician) Memorial University, St. John?s Newfoundland: Carol Joyce (director), Christopher S. Kovacs (co-director). Dalhousie University, Halifax, Nova Scotia: Susan Kirkland, Stephanie M. Kaiser (co-directors). Laval University, Quebec City, Quebec: Jacques P. Brown (director), Louis Bessette (co-director), GRMO. Queen?s University, Kingston, Ontario: Tassos P. Anastassiades (director), Tanveer Towheed (co-director), Wilma M. Hopman (investigator). University of Toronto, Toronto, Ontario: Angela M. Cheung (director), Robert G. Josse (co-director), Andy Kin On Wong (co-director). McMaster University, Hamilton, Ontario: Jonathan D. Adachi (director), Alexandra Papaioannou (co-director). University of Saskatchewan, Saskatoon, Saskatchewan: Wojciech P. Olszynski (director), K. Shawn Davison (co-director). University of Calgary, Calgary, Alberta: David A. Hanley (director), Steven K. Boyd (co-director). University of British Columbia, Vancouver, British Columbia: Jerilynn C. Prior (director), Shirin Kalyan (co-director), Brian Lentle (investigator/radiologist), Millan S. Patel (investigator). University of Alberta, Edmonton, Alberta: Stuart D. Jackson (medical physicist). University of Manitoba, Winnipeg, Manitoba: William D. Leslie (investigator/nuclear medicine physician). SNM is a scholar of the Fonds de Recherche du Qu?bec en sant?. AM Cheung holds a Tier 1 Canada Research Chair in Musculoskeletal and Postmenopausal Health. Publisher Copyright: {\textcopyright} 2020, International Osteoporosis Foundation and National Osteoporosis Foundation.",

year = "2020",

month = dec,

day = "1",

doi = "10.1007/s11657-020-00822-4",

language = "English",

volume = "15",

journal = "Archives of Osteoporosis",

issn = "1862-3522",

publisher = "Springer London",

number = "1",

}

TY - JOUR

T1 - Differences in fracture prevalence and in bone mineral density between Chinese and White Canadians

T2 - the Canadian Multicentre Osteoporosis Study (CaMos)

AU - for the CaMOS Research Group

AU - Morin, S. N.

AU - Berger, C.

AU - Liu, W.

AU - Prior, J. C.

AU - Cheung, A. M.

AU - Hanley, D. A.

AU - Boyd, S. K.

AU - Wong, A. K.O.

AU - Papaioannou, A.

AU - Rahme, E.

AU - Goltzman, D.

AU - Kreiger, Nancy

AU - Tenenhouse, Alan

AU - Rahme, Elham

AU - Richards, J. Brent

AU - Berger, Claudie

AU - Joyce, Carol

AU - Kovacs, Christopher S.

AU - Kirkland, Susan

AU - Kaiser, Stephanie M.

AU - Brown, Jacques P.

AU - Bessette, Louis

AU - Anastassiades, Tassos P.

AU - Towheed, Tanveer

AU - Hopman, Wilma M.

AU - Cheung, Angela M.

AU - Josse, Robert G.

AU - Wong, Andy Kin On

AU - Adachi, Jonathan D.

AU - Papaioannou, Alexandra

AU - Olszynski, Wojciech P.

AU - Davison, K. Shawn

AU - Hanley, David A.

AU - Boyd, Steven K.

AU - Prior, Jerilynn C.

AU - Kalyan, Shirin

AU - Lentle, Brian

AU - Patel, Millan S.

AU - Jackson, Stuart D.

AU - Leslie, William D.

N1 - Funding Information: The Canadian Multicentre Osteoporosis Study (CaMos) was funded by the Canadian Institutes of Health Research (CIHR); Amgen Canada Inc; Actavis Pharma Inc (previously Warner Chilcott Canada Co); Dairy Farmers of Canada; Eli Lilly Canada Inc: Eli Lilly and Company; GE Lunar; Hologic Inc; Merck Frosst Canada Ltd; Novartis Pharmaceuticals Canada Inc; P&G Pharmaceuticals Canada Inc; Pfizer Canada Inc; Roche (F. Hoffmann-La Roche Ltd); Sanofi-Aventis Canada Inc (previously Aventis Pharma Inc); Servier Canada Inc; and The Arthritis Society. Funding Information: The authors wish to thank CaMos participants. The Canadian Multicentre Osteoporosis Study (CaMos) was funded by the Canadian Institutes of Health Research (CIHR); Amgen Canada Inc; Actavis Pharma Inc (previously Warner Chilcott Canada Co); Dairy Farmers of Canada; Eli Lilly Canada Inc: Eli Lilly and Company; GE Lunar; Hologic Inc; Merck Frosst Canada Ltd; Novartis Pharmaceuticals Canada Inc; P&G Pharmaceuticals Canada Inc; Pfizer Canada Inc; Roche (F. Hoffmann-La Roche Ltd); Sanofi-Aventis Canada Inc (previously Aventis Pharma Inc); Servier Canada Inc; and The Arthritis Society. The CaMos Research Group David Goltzman (co-principal investigator, McGill University), Nancy Kreiger (co-principal investigator, University of Toronto), Alan Tenenhouse (principal investigator emeritus, Toronto). McGill University, Montreal, Quebec: Elham Rahme (biostatistician), J. Brent Richards (investigator), Suzanne N. Morin (investigator); Claudie Berger (study statistician) Memorial University, St. John?s Newfoundland: Carol Joyce (director), Christopher S. Kovacs (co-director). Dalhousie University, Halifax, Nova Scotia: Susan Kirkland, Stephanie M. Kaiser (co-directors). Laval University, Quebec City, Quebec: Jacques P. Brown (director), Louis Bessette (co-director), GRMO. Queen?s University, Kingston, Ontario: Tassos P. Anastassiades (director), Tanveer Towheed (co-director), Wilma M. Hopman (investigator). University of Toronto, Toronto, Ontario: Angela M. Cheung (director), Robert G. Josse (co-director), Andy Kin On Wong (co-director). McMaster University, Hamilton, Ontario: Jonathan D. Adachi (director), Alexandra Papaioannou (co-director). University of Saskatchewan, Saskatoon, Saskatchewan: Wojciech P. Olszynski (director), K. Shawn Davison (co-director). University of Calgary, Calgary, Alberta: David A. Hanley (director), Steven K. Boyd (co-director). University of British Columbia, Vancouver, British Columbia: Jerilynn C. Prior (director), Shirin Kalyan (co-director), Brian Lentle (investigator/radiologist), Millan S. Patel (investigator). University of Alberta, Edmonton, Alberta: Stuart D. Jackson (medical physicist). University of Manitoba, Winnipeg, Manitoba: William D. Leslie (investigator/nuclear medicine physician). SNM is a scholar of the Fonds de Recherche du Qu?bec en sant?. AM Cheung holds a Tier 1 Canada Research Chair in Musculoskeletal and Postmenopausal Health. Publisher Copyright: © 2020, International Osteoporosis Foundation and National Osteoporosis Foundation.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Summary: Fracture determinants differ between Canadians of Chinese and White descent, the former constituting the second largest visible minority group in Canada. The results of this study support the importance of characterizing bone health predictors in Canadians of different ethnicity to improve population-specific fracture prevention and treatment strategies. Purpose: We aimed to compare clinical risk factors, bone mineral density, prevalence of osteoporosis, and fractures between Chinese and White Canadians to identify ethnicity-specific risks. Methods: We studied 236 Chinese and 8945 White Canadians aged 25+ years from the Canadian Multicentre Osteoporosis Study (CaMos). The prevalence of osteoporosis using ethnicity-specific peak bone mass (PBM), and of prior and incident low trauma fractures were assessed and compared between groups. Linear regressions, adjusting for age and anthropometric measures, were used to examine the association between baseline and 5-year changes in BMD and ethnicity. Results: Chinese participants had shorter stature, lower BMI, and lower rate of falls than White participants. Adjusted models showed no significant differences in baseline BMD between ethnic groups except in younger men where total hip BMD was 0.059 g/cm2 (0.009; 0.108) lower in Chinese. Adjusted 5-year BMD change at lumbar spine was higher in older Chinese women and men compared with Whites. When using Chinese-specific PBM, the prevalence of osteoporosis in Chinese women was 2-fold lower than when using that of White women The prevalence of fractures was higher in White women compared with Chinese with differences up to 14.5% (95% CI 9.2; 19.7) and 10.5% (95% CI 4.5–16.4) in older White men. Incident fractures were rare in young Chinese compared with White participants and not different in the older groups. Conclusion: Our results support the importance of characterizing bone strength predictors in Chinese Canadians and the development of ethnicity-specific fracture prediction and prevention strategies.

AB - Summary: Fracture determinants differ between Canadians of Chinese and White descent, the former constituting the second largest visible minority group in Canada. The results of this study support the importance of characterizing bone health predictors in Canadians of different ethnicity to improve population-specific fracture prevention and treatment strategies. Purpose: We aimed to compare clinical risk factors, bone mineral density, prevalence of osteoporosis, and fractures between Chinese and White Canadians to identify ethnicity-specific risks. Methods: We studied 236 Chinese and 8945 White Canadians aged 25+ years from the Canadian Multicentre Osteoporosis Study (CaMos). The prevalence of osteoporosis using ethnicity-specific peak bone mass (PBM), and of prior and incident low trauma fractures were assessed and compared between groups. Linear regressions, adjusting for age and anthropometric measures, were used to examine the association between baseline and 5-year changes in BMD and ethnicity. Results: Chinese participants had shorter stature, lower BMI, and lower rate of falls than White participants. Adjusted models showed no significant differences in baseline BMD between ethnic groups except in younger men where total hip BMD was 0.059 g/cm2 (0.009; 0.108) lower in Chinese. Adjusted 5-year BMD change at lumbar spine was higher in older Chinese women and men compared with Whites. When using Chinese-specific PBM, the prevalence of osteoporosis in Chinese women was 2-fold lower than when using that of White women The prevalence of fractures was higher in White women compared with Chinese with differences up to 14.5% (95% CI 9.2; 19.7) and 10.5% (95% CI 4.5–16.4) in older White men. Incident fractures were rare in young Chinese compared with White participants and not different in the older groups. Conclusion: Our results support the importance of characterizing bone strength predictors in Chinese Canadians and the development of ethnicity-specific fracture prediction and prevention strategies.

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DO - 10.1007/s11657-020-00822-4

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JO - Archives of Osteoporosis

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ER -

Differences in fracture prevalence and in bone mineral density between Chinese and White Canadians: the Canadian Multicentre Osteoporosis Study (CaMos)

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Nota bibliográfica

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