Disruption of DYRK1A-induced hyperphosphorylation of amyloid-beta and tau protein in Alzheimer’s disease: An integrative molecular modeling approach

Medicine & Life Sciences

• Alzheimer Disease 43%
• Amyloid 26%
• Amyloid beta-Peptides 63%
• Density Functional Theory 24%
• Dyrk kinase 100%
• Enzymes 7%
• Health Care Outcome Assessment 9%
• In Vitro Techniques 6%
• Molecular Dynamics Simulation 15%
• Nervous System Diseases 13%
• Neurofibrillary Tangles 34%
• Pharmacokinetics 21%
• Phosphorylation 9%
• Principal Component Analysis 15%
• Proteins 5%
• tau Proteins 70%

Chemical Compounds

• Antagonist 13%
• Beta-Amyloid 63%
• Density Functional Theory 8%
• Disorder 12%
• Gibbs Free Energy 21%
• Kd 10%
• Molecular Dynamics 10%
• Molecular Modeling 51%
• Molecule 9%
• Pharmacokinetics 21%
• Pharmacological Metabolism 10%
• Protein 23%
• Simulation 8%
• Tyrosine 51%