Effect of histamine and H1- and H2-agonists on the fractional outflow of radioactivity from the rat vas deferens preloaded with [3H]-noradrenaline

C. M. MacIntosh; M. M. Vohra

doi:10.1016/0024-3205(82)90671-3

Effect of histamine and H₁- and H₂-agonists on the fractional outflow of radioactivity from the rat vas deferens preloaded with [³H]-noradrenaline

C. M. MacIntosh, M. M. Vohra

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

4 Citas (Scopus)

Resumen

Histamine and relatively selective H₁- and H₂-receptor agonists caused a concentration-dependent increase in the fractional outflow of radioactivity from the rat isolated vas deferens preloaded with labelled noradrenaline. The evoked fractional outflow of radioactivity was not preferentially associated with either H₁- or H₂-selective agonists, nor was it related to the known potencies of the agonists within each group. The evoked fractional outflow caused by all compounds studied was independent of the extracellular Ca²⁺ concentration. The study cautions against ascribing all the effects of histamine analogs to their respective histamine receptor stimulation.

Idioma original	English
Páginas (desde-hasta)	2819-2826
Número de páginas	8
Publicación	Life Sciences
Volumen	31
N.º	25
DOI	https://doi.org/10.1016/0024-3205(82)90671-3
Estado	Published - dic. 20 1982

Nota bibliográfica

Funding Information:
We thank Dr. C. R. Ganellln of Smith Kllne and French Laboratories, England, for the generous gift of various histamine analogs used in this study. The work was supported by a grant from the Medical Research Councll of Canada.

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

Acceder al documento

10.1016/0024-3205(82)90671-3

Otros archivos y enlaces

Citar esto

@article{eb016ecc0e0b4c6796ef8b0f9275b5cd,

title = "Effect of histamine and H1- and H2-agonists on the fractional outflow of radioactivity from the rat vas deferens preloaded with [3H]-noradrenaline",

abstract = "Histamine and relatively selective H1- and H2-receptor agonists caused a concentration-dependent increase in the fractional outflow of radioactivity from the rat isolated vas deferens preloaded with labelled noradrenaline. The evoked fractional outflow of radioactivity was not preferentially associated with either H1- or H2-selective agonists, nor was it related to the known potencies of the agonists within each group. The evoked fractional outflow caused by all compounds studied was independent of the extracellular Ca2+ concentration. The study cautions against ascribing all the effects of histamine analogs to their respective histamine receptor stimulation.",

author = "MacIntosh, {C. M.} and Vohra, {M. M.}",

note = "Funding Information: We thank Dr. C. R. Ganellln of Smith Kllne and French Laboratories, England, for the generous gift of various histamine analogs used in this study. The work was supported by a grant from the Medical Research Councll of Canada.",

year = "1982",

month = dec,

day = "20",

doi = "10.1016/0024-3205(82)90671-3",

language = "English",

volume = "31",

pages = "2819--2826",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "25",

}

TY - JOUR

T1 - Effect of histamine and H1- and H2-agonists on the fractional outflow of radioactivity from the rat vas deferens preloaded with [3H]-noradrenaline

AU - MacIntosh, C. M.

AU - Vohra, M. M.

N1 - Funding Information: We thank Dr. C. R. Ganellln of Smith Kllne and French Laboratories, England, for the generous gift of various histamine analogs used in this study. The work was supported by a grant from the Medical Research Councll of Canada.

PY - 1982/12/20

Y1 - 1982/12/20

N2 - Histamine and relatively selective H1- and H2-receptor agonists caused a concentration-dependent increase in the fractional outflow of radioactivity from the rat isolated vas deferens preloaded with labelled noradrenaline. The evoked fractional outflow of radioactivity was not preferentially associated with either H1- or H2-selective agonists, nor was it related to the known potencies of the agonists within each group. The evoked fractional outflow caused by all compounds studied was independent of the extracellular Ca2+ concentration. The study cautions against ascribing all the effects of histamine analogs to their respective histamine receptor stimulation.

AB - Histamine and relatively selective H1- and H2-receptor agonists caused a concentration-dependent increase in the fractional outflow of radioactivity from the rat isolated vas deferens preloaded with labelled noradrenaline. The evoked fractional outflow of radioactivity was not preferentially associated with either H1- or H2-selective agonists, nor was it related to the known potencies of the agonists within each group. The evoked fractional outflow caused by all compounds studied was independent of the extracellular Ca2+ concentration. The study cautions against ascribing all the effects of histamine analogs to their respective histamine receptor stimulation.

UR - http://www.scopus.com/inward/record.url?scp=0020333678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020333678&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(82)90671-3

DO - 10.1016/0024-3205(82)90671-3

M3 - Article

C2 - 7162353

AN - SCOPUS:0020333678

SN - 0024-3205

VL - 31

SP - 2819

EP - 2826

JO - Life Sciences

JF - Life Sciences

IS - 25

ER -