Effect of monoamine oxidase inhibitors on the n-demethylation and hydrolysis of meperidine

N. R. Eade, K. W. Renton

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22 Citas (Scopus)

Resumen

The administration of meperidine to patients being treated with a monoamine oxidase inhibitor (MAOI) can produce lethal reactions of unknown etiology. Inhibition of microsomal degradation of meperidine has been suggested as the explanation of these reactions. In this study the kinetics of the inhibition of N-demethylation and hydrolysis of meperidine by six MAOI and SKF-525A are described. The hydrazine MAOI, phenelzine and iproniazid, d- and l-amphetamine and SKF-525A, were competitive inhibitors of meperidine N-demethylation, while pargyline and tranylcypromine were noncompetitive inhibitors. The hydrolysis of meperidine was inhibited only by pargyline and the inhibition was competitive. The possibility that inhibition of both N-demethylation and hydrolysis of meperidine may be involved in the etiology of the adverse reactions which occur between the MAOI and meperidine is discussed.

Idioma originalEnglish
Páginas (desde-hasta)2243-2250
Número de páginas8
PublicaciónBiochemical Pharmacology
Volumen19
N.º7
DOI
EstadoPublished - jul. 1970
Publicado de forma externa

Nota bibliográfica

Funding Information:
* This work was supported by Grant MA 2339 from the Medical Research Council of Canada and by the Canadian Foundation for the Advancement of Therapeutics.

ASJC Scopus Subject Areas

  • Biochemistry
  • Pharmacology

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