Electrochemically assisted co-precipitation of protein with calcium phosphate coatings on titanium alloy

Xiaoliang Cheng; Mark Filiaggi; Sharon G. Roscoe

doi:10.1016/j.biomaterials.2003.12.045

Electrochemically assisted co-precipitation of protein with calcium phosphate coatings on titanium alloy

Xiaoliang Cheng, Mark Filiaggi, Sharon G. Roscoe

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

77 Citas (Scopus)

Resumen

A bovine serum albumin protein-containing calcium phosphate coating (BSA/brushite) was prepared by electrochemically assisted co-precipitation onto a hydroxyapatite (HA) coated Ti-6Al-4V surface. Electrochemically assisted co-precipitation of BSA/brushite coatings onto HA resulted in a 70-fold increase in BSA inclusion compared to simple adsorption, and was subsequently released by a slower mechanism (15% loss over 70h). Thus, this electrochemically assisted co-precipitation technique provides an efficient method of protein incorporation at physiological temperature, with a potential for sustained release of therapeutic agents as may be required for metallic implant fixation.

Idioma original	English
Páginas (desde-hasta)	5395-5403
Número de páginas	9
Publicación	Biomaterials
Volumen	25
N.º	23
DOI	https://doi.org/10.1016/j.biomaterials.2003.12.045
Estado	Published - oct. 2004

Nota bibliográfica

Funding Information:
The authors wish to thank Dr. Kathy Robertson and Prof. Stanley Cameron, Dalhousie University, for XRD measurements. Grateful acknowledgment is made to the Natural Science and Engineering Research Council of Canada and the Nova Scotia Health Research Foundation for support of this research.

ASJC Scopus Subject Areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/j.biomaterials.2003.12.045

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title = "Electrochemically assisted co-precipitation of protein with calcium phosphate coatings on titanium alloy",

abstract = "A bovine serum albumin protein-containing calcium phosphate coating (BSA/brushite) was prepared by electrochemically assisted co-precipitation onto a hydroxyapatite (HA) coated Ti-6Al-4V surface. Electrochemically assisted co-precipitation of BSA/brushite coatings onto HA resulted in a 70-fold increase in BSA inclusion compared to simple adsorption, and was subsequently released by a slower mechanism (15% loss over 70h). Thus, this electrochemically assisted co-precipitation technique provides an efficient method of protein incorporation at physiological temperature, with a potential for sustained release of therapeutic agents as may be required for metallic implant fixation.",

author = "Xiaoliang Cheng and Mark Filiaggi and Roscoe, {Sharon G.}",

note = "Funding Information: The authors wish to thank Dr. Kathy Robertson and Prof. Stanley Cameron, Dalhousie University, for XRD measurements. Grateful acknowledgment is made to the Natural Science and Engineering Research Council of Canada and the Nova Scotia Health Research Foundation for support of this research. ",

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AU - Filiaggi, Mark

AU - Roscoe, Sharon G.

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Electrochemically assisted co-precipitation of protein with calcium phosphate coatings on titanium alloy

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

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