Erythropoietin-dependent erythropoiesis: New insights and questions

Don M. Wojchowski, Madhu P. Menon, Pradeep Sathyanarayana, Jing Fang, Vinit Karur, Estelle Houde, William Kapelle, Oleg Bogachev

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

39 Citas (Scopus)

Resumen

Committed erythroid progenitor cells require exposure to erythropoietin (Epo) for their survival and for their quantitatively regulated transition to red blood cells. With regard to Epo signal transduction mechanisms, much has been learned from analyses in cell line models, fetal liver or spleen-derived primary erythroblasts and human CD34pos progenitor cells from cord blood or mobilized bone marrow. Presently, we have developed an ex vivo system that efficiently supports the expansion and development of murine adult bone-marrow-derived erythroid progenitor cells. This system is outlined together with its demonstrated utility in studying (for the first time) the signaling capacities of two knocked-in phosphotyrosine-deficient Epo receptor alleles (EpoR-H and EpoR-HM). Ways in which these studies advance an understanding of core Epo signal transduction events are outlined. Also introduced are two new putative negative regulators of Epo-dependent erythropoiesis, DYRK3 and DAPK2 kinases.

Idioma originalEnglish
Páginas (desde-hasta)232-238
Número de páginas7
PublicaciónBlood Cells, Molecules, and Diseases
Volumen36
N.º2
DOI
EstadoPublished - mar. 2006
Publicado de forma externa

Nota bibliográfica

Funding Information:
Supported by NIH grants (to DMW) R01HL44491, R01DK59472 and P20RR18789.

ASJC Scopus Subject Areas

  • Molecular Medicine
  • Molecular Biology
  • Hematology
  • Cell Biology

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Review

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