Evidence for the presence of β2-inhibitory adrenoceptors in the rat vas deferens

M. M. Vohra

doi:10.1016/0306-3623(79)90093-4

Evidence for the presence of β₂-inhibitory adrenoceptors in the rat vas deferens

M. M. Vohra

Medicine

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

19 Citas (Scopus)

Resumen

1. 1. Isoprenaline and to a lesser extent adrenaline but not noradrenaline depressed, in a dose-related manner, contractile responses of rat isolated vasa deferentia caused by electrical field stimulation or by added agonists in the absence or presence of phentolamine. 2. 2. Isoprenaline inhibition of contractions caused by field stimulation or added agonists was abolished preferentially by propranolol or timolol but not practolol. 3. 3. These findings demonstrate the presence of postjunctional β₂-inhibitory adrenoceptors in rat vas deferens. 4. 4. The α-adrenoceptors in rat vas deferens were exceptionally sensitive to isoprenaline. Consequently, α-stimulant activity of isoprenaline was found to interfere with the determination of its β-mimetic activity.

Idioma original	English
Páginas (desde-hasta)	221-225
Número de páginas	5
Publicación	Vascular Pharmacology
Volumen	10
N.º	3
DOI	https://doi.org/10.1016/0306-3623(79)90093-4
Estado	Published - 1979

Nota bibliográfica

Funding Information:
Acknowledgement.s--I wish to thank Miss Nancy Cannon for technical assistance and the various pharmaceutical companies for generously supplying drugs used in this study. This work was supported by a grant from the Medical Research Council of Canada.

ASJC Scopus Subject Areas

Pharmacology

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10.1016/0306-3623(79)90093-4

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title = "Evidence for the presence of β2-inhibitory adrenoceptors in the rat vas deferens",

abstract = "1. 1. Isoprenaline and to a lesser extent adrenaline but not noradrenaline depressed, in a dose-related manner, contractile responses of rat isolated vasa deferentia caused by electrical field stimulation or by added agonists in the absence or presence of phentolamine. 2. 2. Isoprenaline inhibition of contractions caused by field stimulation or added agonists was abolished preferentially by propranolol or timolol but not practolol. 3. 3. These findings demonstrate the presence of postjunctional β2-inhibitory adrenoceptors in rat vas deferens. 4. 4. The α-adrenoceptors in rat vas deferens were exceptionally sensitive to isoprenaline. Consequently, α-stimulant activity of isoprenaline was found to interfere with the determination of its β-mimetic activity.",

author = "Vohra, {M. M.}",

note = "Funding Information: Acknowledgement.s--I wish to thank Miss Nancy Cannon for technical assistance and the various pharmaceutical companies for generously supplying drugs used in this study. This work was supported by a grant from the Medical Research Council of Canada.",

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N2 - 1. 1. Isoprenaline and to a lesser extent adrenaline but not noradrenaline depressed, in a dose-related manner, contractile responses of rat isolated vasa deferentia caused by electrical field stimulation or by added agonists in the absence or presence of phentolamine. 2. 2. Isoprenaline inhibition of contractions caused by field stimulation or added agonists was abolished preferentially by propranolol or timolol but not practolol. 3. 3. These findings demonstrate the presence of postjunctional β2-inhibitory adrenoceptors in rat vas deferens. 4. 4. The α-adrenoceptors in rat vas deferens were exceptionally sensitive to isoprenaline. Consequently, α-stimulant activity of isoprenaline was found to interfere with the determination of its β-mimetic activity.

AB - 1. 1. Isoprenaline and to a lesser extent adrenaline but not noradrenaline depressed, in a dose-related manner, contractile responses of rat isolated vasa deferentia caused by electrical field stimulation or by added agonists in the absence or presence of phentolamine. 2. 2. Isoprenaline inhibition of contractions caused by field stimulation or added agonists was abolished preferentially by propranolol or timolol but not practolol. 3. 3. These findings demonstrate the presence of postjunctional β2-inhibitory adrenoceptors in rat vas deferens. 4. 4. The α-adrenoceptors in rat vas deferens were exceptionally sensitive to isoprenaline. Consequently, α-stimulant activity of isoprenaline was found to interfere with the determination of its β-mimetic activity.

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