Resumen
Improving the therapeutic efficacy of conventional anticancer drugs represents the best hope for cancer treatment. However, the shortage of druggable targets and the increasing development of anticancer drug resistance remain significant problems. Recently, membrane transport proteins have emerged as novel therapeutic targets for cancer treatment. These proteins are essential for a plethora of cell functions ranging from cell homeostasis to clinical drug toxicity. Furthermore, their association with carcinogenesis and chemoresistance has opened new vistas for pharmacology-based cancer research. This review provides a comprehensive update of our current knowledge on the functional expression profile of membrane transport proteins in cancer and chemoresistant tumours that may form the basis for new cancer treatment strategies.
| Idioma original | English |
|---|---|
| Número de artículo | 1624 |
| Páginas (desde-hasta) | 1-31 |
| Número de páginas | 31 |
| Publicación | Cancers |
| Volumen | 12 |
| N.º | 6 |
| DOI | |
| Estado | Published - jun. 2020 |
Nota bibliográfica
Funding Information:This research was funded by Research NS Establishment grant number 2019-2174 and NSERC Discovery grant 2018-05528. Acknowledgments: We thank Xingjian Zhai for his insightful comments and edits on this review paper.
Funding Information:
Funding: This research was funded by ResearchNS Establishment grant number 2019-2174 and NSERC Discovery grant 2018-05528.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
ASJC Scopus Subject Areas
- Oncology
- Cancer Research
PubMed: MeSH publication types
- Journal Article
- Review
ODS de las Naciones Unidas
Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible
