Resumen
Knowledge regarding the relationship between the molecular mechanisms underlying atherosclerosis (AS) and transfer RNA-derived small RNAs (tsRNAs) is limited. This study illustrated the expression profile of tsRNAs, thus exploring its roles in AS pathogenesis. Small RNA sequencing was performed with four atherosclerotic arterial and four healthy subject samples. Using bioinformatics, the protein-protein interaction network and cellular experiments were constructed to predict the enriched signalling pathways and regulatory roles of tsRNAs in AS. Of the total 315 tsRNAs identified to be dysregulated in the AS group, 131 and 184 were up-regulated and down-regulated, respectively. Interestingly, the pathway of the differentiated expression of tsRNAs in cell adhesion molecules (CAMs) was implicated to be closely associated with AS. Particularly, tRF-Gly-GCC might participate in AS pathogenesis via regulating cell adhesion, proliferation, migration and phenotypic transformation in HUVECs and VSMCs. In conclusion, tsRNAs might help understand the molecular mechanisms of AS better. tRF-Gly-GCC may be a promising target for suppressing abnormal vessels functions, suggesting a novel strategy for preventing the progression of atherosclerosis.
Idioma original | English |
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Páginas (desde-hasta) | 7052-7065 |
Número de páginas | 14 |
Publicación | Journal of Cellular and Molecular Medicine |
Volumen | 25 |
N.º | 14 |
DOI | |
Estado | Published - jul. 2021 |
Publicado de forma externa | Sí |
Nota bibliográfica
Funding Information:The study was supported by The National Natural Science Foundation of China (grant no. 81870331, 31701208), and The Qingdao municipal science and technology bureau project (grant no. 21‐1‐4‐rkjk‐12‐nsh).
Publisher Copyright:
© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
ASJC Scopus Subject Areas
- Molecular Medicine
- Cell Biology
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't