Frailty index to measure health status in people with systemic sclerosis

Michael R. Rockwood, Ellen MacDonald, Evelyn Sutton, Kenneth Rockwood, Murray Baron

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

51 Citas (Scopus)

Resumen

Objective. To develop and validate, as a measure of overall health status, a Frailty Index (FI) for patients (n = 1372) in the Canadian Scleroderma Research Group (CSRG) Registry. Methods. Forty-four items were selected from the CSRG database as health deficits and recoded using FI criteria. To test construct validity, we compared measurement properties of the CSRG-FI to other FI, and related it to measures of damage, age, and time since diagnosis. To test criterion validity, we compared the baseline FI to that at last recorded visit and to mortality. Results. The mean CSRG-FI was 0.33 with a sub-maximal limit of 0.67. In patients with diffuse disease, the mean was 0.38(SD 0.14); in patients with limited disease, the mean was 0.31(SD 0.13). The CSRG-FI was weakly (but significantly) correlated with the Rodnan Skin Score (r = 0.28 in people with diffuse disease; 0.18 with limited) and moderately with the Physician Assessment of Damage (r = 0.51 for both limited and diffuse). The risk of death increased with higher FI scores and with higher physician ratings of damage. The area under the receiver operating characteristic curve for the baseline FI in relation to death was 0.75, higher than for other measures (range: 0.57-0.67). Conclusion. The FI quantifies overall health status in people with scleroderma and predicts mortality. Whether the FI might help with decisions about who might best be served by more aggressive treatment, such as bone marrow transplantation, needs to be evaluated.

Idioma originalEnglish
Páginas (desde-hasta)698-705
Número de páginas8
PublicaciónJournal of Rheumatology
Volumen41
N.º4
DOI
EstadoPublished - abr. 2014

ASJC Scopus Subject Areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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