Frailty prevalence in the COMPASS-ND study of neurodegenerative disorders

Jacqueline R. Burt; Judith Godin; Josée Filion; Manuel Montero-Odasso; Kenneth Rockwood; Melissa K. Andrew; Richard Camicioli

doi:10.5770/cgj.22.392

Frailty prevalence in the COMPASS-ND study of neurodegenerative disorders

Jacqueline R. Burt, Judith Godin, Josée Filion, Manuel Montero-Odasso, Kenneth Rockwood, Melissa K. Andrew, Richard Camicioli

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

7 Citas (Scopus)

Resumen

Background Frailty is characterized by increased vulnerability to adverse health outcomes. The prevalence of frailty across neurodegenerative disorders (NDD) is largely unknown. Symptoms of frailty and NDD overlap, calling into question a tautology in some frailty instruments. Our objectives were 1) to construct a Frailty Index (FI) independent of NDD symptoms, and 2) to estimate frailty prevalence in a broad NDD cohort using both the Frailty Phenotype (FP) and the constructed FI as measures. Methods Data from the Canadian COMPASS-ND cohort study were assessed for applicability to FI construction. Frailty status according to FI and FP criteria were ascertained for each participant. Results 81 items were selected for the FI. In the cohort (150 participants; 46% women; mean age 73.6±7.0; 10 NDD subgroups), frailty was identified in 11% and 14% of participants according to the FI and FP, respectively. The difference between estimates was not significant. The FP classified most participants (84%) as pre-frail. Conclusion The presence of frailty elements, regardless of whether they are part of NDD, is likely to influence health status. Given the FP identified a large proportion of the cohort as pre-frail or frail, it is likely worthwhile to identify frailty in the context of NDD.

Idioma original	English
Páginas (desde-hasta)	205-212
Número de páginas	8
Publicación	Canadian Geriatrics Journal
Volumen	22
N.º	4
DOI	https://doi.org/10.5770/cgj.22.392
Estado	Published - 2019

Nota bibliográfica

Funding Information:
by a grant from the Canadian Institutes of Health Research with funding from several partners (www.ccna-ccnv.ca). The CCNA designed the COMPASS-ND study, and funded subject recruitment and data collection. The authors were funded by the CCNA through involvement in various CCNA team activities. This project was a collaboration between members of Team 8 (Lewy Bodies, Aging and Dementia), Team 12 (Mobility, Exercise and Cognition), and Team 14 (How Multi-Morbidity Modifies the Risk of Dementia and the Patterns of Disease Expression). The CCNA and its partners had no role in the design, analysis, or preparation of this paper.

Funding Information:
This work was supported by the Canadian Consortium on Neurodegeneration in Aging (CCNA) which itself is supported

Publisher Copyright:
© 2019 Author(s).

ASJC Scopus Subject Areas

Gerontology
Geriatrics and Gerontology

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title = "Frailty prevalence in the COMPASS-ND study of neurodegenerative disorders",

abstract = "Background Frailty is characterized by increased vulnerability to adverse health outcomes. The prevalence of frailty across neurodegenerative disorders (NDD) is largely unknown. Symptoms of frailty and NDD overlap, calling into question a tautology in some frailty instruments. Our objectives were 1) to construct a Frailty Index (FI) independent of NDD symptoms, and 2) to estimate frailty prevalence in a broad NDD cohort using both the Frailty Phenotype (FP) and the constructed FI as measures. Methods Data from the Canadian COMPASS-ND cohort study were assessed for applicability to FI construction. Frailty status according to FI and FP criteria were ascertained for each participant. Results 81 items were selected for the FI. In the cohort (150 participants; 46% women; mean age 73.6±7.0; 10 NDD subgroups), frailty was identified in 11% and 14% of participants according to the FI and FP, respectively. The difference between estimates was not significant. The FP classified most participants (84%) as pre-frail. Conclusion The presence of frailty elements, regardless of whether they are part of NDD, is likely to influence health status. Given the FP identified a large proportion of the cohort as pre-frail or frail, it is likely worthwhile to identify frailty in the context of NDD.",

author = "Burt, {Jacqueline R.} and Judith Godin and Jos{\'e}e Filion and Manuel Montero-Odasso and Kenneth Rockwood and Andrew, {Melissa K.} and Richard Camicioli",

note = "Funding Information: by a grant from the Canadian Institutes of Health Research with funding from several partners (www.ccna-ccnv.ca). The CCNA designed the COMPASS-ND study, and funded subject recruitment and data collection. The authors were funded by the CCNA through involvement in various CCNA team activities. This project was a collaboration between members of Team 8 (Lewy Bodies, Aging and Dementia), Team 12 (Mobility, Exercise and Cognition), and Team 14 (How Multi-Morbidity Modifies the Risk of Dementia and the Patterns of Disease Expression). The CCNA and its partners had no role in the design, analysis, or preparation of this paper. Funding Information: This work was supported by the Canadian Consortium on Neurodegeneration in Aging (CCNA) which itself is supported Publisher Copyright: {\textcopyright} 2019 Author(s).",

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doi = "10.5770/cgj.22.392",

language = "English",

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AU - Burt, Jacqueline R.

AU - Godin, Judith

AU - Filion, Josée

AU - Montero-Odasso, Manuel

AU - Rockwood, Kenneth

AU - Andrew, Melissa K.

AU - Camicioli, Richard

N1 - Funding Information: by a grant from the Canadian Institutes of Health Research with funding from several partners (www.ccna-ccnv.ca). The CCNA designed the COMPASS-ND study, and funded subject recruitment and data collection. The authors were funded by the CCNA through involvement in various CCNA team activities. This project was a collaboration between members of Team 8 (Lewy Bodies, Aging and Dementia), Team 12 (Mobility, Exercise and Cognition), and Team 14 (How Multi-Morbidity Modifies the Risk of Dementia and the Patterns of Disease Expression). The CCNA and its partners had no role in the design, analysis, or preparation of this paper. Funding Information: This work was supported by the Canadian Consortium on Neurodegeneration in Aging (CCNA) which itself is supported Publisher Copyright: © 2019 Author(s).

PY - 2019

Y1 - 2019

N2 - Background Frailty is characterized by increased vulnerability to adverse health outcomes. The prevalence of frailty across neurodegenerative disorders (NDD) is largely unknown. Symptoms of frailty and NDD overlap, calling into question a tautology in some frailty instruments. Our objectives were 1) to construct a Frailty Index (FI) independent of NDD symptoms, and 2) to estimate frailty prevalence in a broad NDD cohort using both the Frailty Phenotype (FP) and the constructed FI as measures. Methods Data from the Canadian COMPASS-ND cohort study were assessed for applicability to FI construction. Frailty status according to FI and FP criteria were ascertained for each participant. Results 81 items were selected for the FI. In the cohort (150 participants; 46% women; mean age 73.6±7.0; 10 NDD subgroups), frailty was identified in 11% and 14% of participants according to the FI and FP, respectively. The difference between estimates was not significant. The FP classified most participants (84%) as pre-frail. Conclusion The presence of frailty elements, regardless of whether they are part of NDD, is likely to influence health status. Given the FP identified a large proportion of the cohort as pre-frail or frail, it is likely worthwhile to identify frailty in the context of NDD.

AB - Background Frailty is characterized by increased vulnerability to adverse health outcomes. The prevalence of frailty across neurodegenerative disorders (NDD) is largely unknown. Symptoms of frailty and NDD overlap, calling into question a tautology in some frailty instruments. Our objectives were 1) to construct a Frailty Index (FI) independent of NDD symptoms, and 2) to estimate frailty prevalence in a broad NDD cohort using both the Frailty Phenotype (FP) and the constructed FI as measures. Methods Data from the Canadian COMPASS-ND cohort study were assessed for applicability to FI construction. Frailty status according to FI and FP criteria were ascertained for each participant. Results 81 items were selected for the FI. In the cohort (150 participants; 46% women; mean age 73.6±7.0; 10 NDD subgroups), frailty was identified in 11% and 14% of participants according to the FI and FP, respectively. The difference between estimates was not significant. The FP classified most participants (84%) as pre-frail. Conclusion The presence of frailty elements, regardless of whether they are part of NDD, is likely to influence health status. Given the FP identified a large proportion of the cohort as pre-frail or frail, it is likely worthwhile to identify frailty in the context of NDD.

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Frailty prevalence in the COMPASS-ND study of neurodegenerative disorders

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ASJC Scopus Subject Areas

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