Gender influences on hepatitis c incidence among street youth in a Canadian setting

Nitasha Puri; Kora Debeck; Cindy Feng; Thomas Kerr; Launette Rieb; Evan Wood

doi:10.1016/j.jadohealth.2014.07.006

Gender influences on hepatitis c incidence among street youth in a Canadian setting

Nitasha Puri, Kora Debeck, Cindy Feng, Thomas Kerr, Launette Rieb, Evan Wood

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12 Citas (Scopus)

Resumen

Purpose Few studies have examined gender-based differences in the risk of hepatitis C virus (HCV) infection among street-involved youth. We compared rates of HCV infection among male and female street-involved youth in a Canadian setting.

Methods The At-Risk Youth Study is a prospective cohort of drug-using street-involved youth. Study recruitment and follow-up occurred in Vancouver, Canada, between September 2005 and November 2011. Eligible participants were illicit drug-using youth aged 14-26 years at enrollment, recruited by street-based outreach. We evaluated rates of HCV antibody seroconversion, measured every 6 months during study follow-up, and used Cox proportional hazards regression to compare risk factors for HCV incidence between male and female street youth.

Results Among 512 HCV-seronegative youth contributing 836 person-years of follow-up, 56 (10.9%) seroconverted to HCV. Among female participants, the incidence density of HCV infection was 10.9 per 100 person-years, and in males, it was 5.1 per 100 person-years (p =.009). In multivariate analyses, female gender was independently associated with a higher rate of HCV seroconversion (adjusted hazard ratio, 2.01; 95% confidence interval, 1.18-3.44). Risk factors were similar in gender-stratified analyses and included heroin injection and crystal methamphetamine injection, although syringe sharing was only associated with HCV incidence among males.

Conclusions Among street-involved youth in this setting, females had double the incidence of HCV seroconversion demonstrating the need for gender-focused HCV prevention interventions for this population.

Idioma original	English
Páginas (desde-hasta)	830-834
Número de páginas	5
Publicación	Journal of Adolescent Health
Volumen	55
N.º	6
DOI	https://doi.org/10.1016/j.jadohealth.2014.07.006
Estado	Published - dic. 1 2014
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
The study was supported by the U.S. National Institutes of Health ( R01DA028532 ) and the Canadian Institutes of Health Research ( MOP–102742 ).

Funding Information:
The authors thank the study participants for their contribution to the research, as well as current and past researchers and staff. The authors would specifically like to thank Cody Callon, Jennifer Matthews, Deborah Graham, Peter Vann, Steve Kain, Tricia Collingham, Kristie Starr, and Carmen Rock for their research and administrative assistance. This research was undertaken, in part, thanks to funding from the Canada Research Chairs program through a Tier 1 Canada Research Chair in Inner City Medicine which supports Dr. Evan Wood. Dr. Kora DeBeck is supported by a Michael Smith Foundation for Health Research/St. Paul's Hospital-Providence Health Care Career Scholar Award.

Publisher Copyright:
© 2014 Society for Adolescent Health and Medicine. All rights reserved.

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health
Public Health, Environmental and Occupational Health
Psychiatry and Mental health

ODS de las Naciones Unidas

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title = "Gender influences on hepatitis c incidence among street youth in a Canadian setting",

abstract = "Purpose Few studies have examined gender-based differences in the risk of hepatitis C virus (HCV) infection among street-involved youth. We compared rates of HCV infection among male and female street-involved youth in a Canadian setting.Methods The At-Risk Youth Study is a prospective cohort of drug-using street-involved youth. Study recruitment and follow-up occurred in Vancouver, Canada, between September 2005 and November 2011. Eligible participants were illicit drug-using youth aged 14-26 years at enrollment, recruited by street-based outreach. We evaluated rates of HCV antibody seroconversion, measured every 6 months during study follow-up, and used Cox proportional hazards regression to compare risk factors for HCV incidence between male and female street youth.Results Among 512 HCV-seronegative youth contributing 836 person-years of follow-up, 56 (10.9%) seroconverted to HCV. Among female participants, the incidence density of HCV infection was 10.9 per 100 person-years, and in males, it was 5.1 per 100 person-years (p =.009). In multivariate analyses, female gender was independently associated with a higher rate of HCV seroconversion (adjusted hazard ratio, 2.01; 95% confidence interval, 1.18-3.44). Risk factors were similar in gender-stratified analyses and included heroin injection and crystal methamphetamine injection, although syringe sharing was only associated with HCV incidence among males.Conclusions Among street-involved youth in this setting, females had double the incidence of HCV seroconversion demonstrating the need for gender-focused HCV prevention interventions for this population.",

author = "Nitasha Puri and Kora Debeck and Cindy Feng and Thomas Kerr and Launette Rieb and Evan Wood",

note = "Funding Information: The study was supported by the U.S. National Institutes of Health ( R01DA028532 ) and the Canadian Institutes of Health Research ( MOP–102742 ). Funding Information: The authors thank the study participants for their contribution to the research, as well as current and past researchers and staff. The authors would specifically like to thank Cody Callon, Jennifer Matthews, Deborah Graham, Peter Vann, Steve Kain, Tricia Collingham, Kristie Starr, and Carmen Rock for their research and administrative assistance. This research was undertaken, in part, thanks to funding from the Canada Research Chairs program through a Tier 1 Canada Research Chair in Inner City Medicine which supports Dr. Evan Wood. Dr. Kora DeBeck is supported by a Michael Smith Foundation for Health Research/St. Paul's Hospital-Providence Health Care Career Scholar Award. Publisher Copyright: {\textcopyright} 2014 Society for Adolescent Health and Medicine. All rights reserved.",

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AU - Puri, Nitasha

AU - Debeck, Kora

AU - Feng, Cindy

AU - Kerr, Thomas

AU - Rieb, Launette

AU - Wood, Evan

N1 - Funding Information: The study was supported by the U.S. National Institutes of Health ( R01DA028532 ) and the Canadian Institutes of Health Research ( MOP–102742 ). Funding Information: The authors thank the study participants for their contribution to the research, as well as current and past researchers and staff. The authors would specifically like to thank Cody Callon, Jennifer Matthews, Deborah Graham, Peter Vann, Steve Kain, Tricia Collingham, Kristie Starr, and Carmen Rock for their research and administrative assistance. This research was undertaken, in part, thanks to funding from the Canada Research Chairs program through a Tier 1 Canada Research Chair in Inner City Medicine which supports Dr. Evan Wood. Dr. Kora DeBeck is supported by a Michael Smith Foundation for Health Research/St. Paul's Hospital-Providence Health Care Career Scholar Award. Publisher Copyright: © 2014 Society for Adolescent Health and Medicine. All rights reserved.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Purpose Few studies have examined gender-based differences in the risk of hepatitis C virus (HCV) infection among street-involved youth. We compared rates of HCV infection among male and female street-involved youth in a Canadian setting.Methods The At-Risk Youth Study is a prospective cohort of drug-using street-involved youth. Study recruitment and follow-up occurred in Vancouver, Canada, between September 2005 and November 2011. Eligible participants were illicit drug-using youth aged 14-26 years at enrollment, recruited by street-based outreach. We evaluated rates of HCV antibody seroconversion, measured every 6 months during study follow-up, and used Cox proportional hazards regression to compare risk factors for HCV incidence between male and female street youth.Results Among 512 HCV-seronegative youth contributing 836 person-years of follow-up, 56 (10.9%) seroconverted to HCV. Among female participants, the incidence density of HCV infection was 10.9 per 100 person-years, and in males, it was 5.1 per 100 person-years (p =.009). In multivariate analyses, female gender was independently associated with a higher rate of HCV seroconversion (adjusted hazard ratio, 2.01; 95% confidence interval, 1.18-3.44). Risk factors were similar in gender-stratified analyses and included heroin injection and crystal methamphetamine injection, although syringe sharing was only associated with HCV incidence among males.Conclusions Among street-involved youth in this setting, females had double the incidence of HCV seroconversion demonstrating the need for gender-focused HCV prevention interventions for this population.

AB - Purpose Few studies have examined gender-based differences in the risk of hepatitis C virus (HCV) infection among street-involved youth. We compared rates of HCV infection among male and female street-involved youth in a Canadian setting.Methods The At-Risk Youth Study is a prospective cohort of drug-using street-involved youth. Study recruitment and follow-up occurred in Vancouver, Canada, between September 2005 and November 2011. Eligible participants were illicit drug-using youth aged 14-26 years at enrollment, recruited by street-based outreach. We evaluated rates of HCV antibody seroconversion, measured every 6 months during study follow-up, and used Cox proportional hazards regression to compare risk factors for HCV incidence between male and female street youth.Results Among 512 HCV-seronegative youth contributing 836 person-years of follow-up, 56 (10.9%) seroconverted to HCV. Among female participants, the incidence density of HCV infection was 10.9 per 100 person-years, and in males, it was 5.1 per 100 person-years (p =.009). In multivariate analyses, female gender was independently associated with a higher rate of HCV seroconversion (adjusted hazard ratio, 2.01; 95% confidence interval, 1.18-3.44). Risk factors were similar in gender-stratified analyses and included heroin injection and crystal methamphetamine injection, although syringe sharing was only associated with HCV incidence among males.Conclusions Among street-involved youth in this setting, females had double the incidence of HCV seroconversion demonstrating the need for gender-focused HCV prevention interventions for this population.

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Gender influences on hepatitis c incidence among street youth in a Canadian setting

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ASJC Scopus Subject Areas

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