TY - JOUR
T1 - High-Frequency Ex vivo Ultrasound Imaging of the Auditory System
AU - Brown, Jeremy A.
AU - Torbatian, Zahra
AU - Adamson, Robert B.
AU - Van Wijhe, Rene
AU - Pennings, Ronald J.
AU - Lockwood, Geoffrey R.
AU - Bance, Manohar L.
PY - 2009/11
Y1 - 2009/11
N2 - A 50 MHz array-based imaging system was used to obtain high-resolution images of the ear and auditory system. This previously described custom built imaging system (Brown et al. 2004a, 2004b; Brown and Lockwood 2005) is capable of 50 μm axial resolution, and lateral resolution varying from 80 μm to 130 μm over a 5.12 mm scan depth. The imaging system is based on a 2 mm diameter, seven-element equal-area annular array, and a digital beamformer that uses high-speed field programmable gate arrays (FPGAs). The images produced by this system have shown far superior depth of field compared with commercially available single-element systems. Ex vivo, three-dimensional (3-D) images were obtained of human cadaveric tissues including the ossicles (stapes, incus, malleus) and the tympanic membrane. In addition, two-dimensional (2-D) images were obtained of an intact cochlea by imaging through the round window membrane. The basilar membrane inside the cochlea could clearly be visualized. These images demonstrate that high-frequency ultrasound imaging of the middle and inner ear can provide valuable diagnostic information using minimally invasive techniques that could potentially be implemented in vivo. (E-mail: J.Brown@dal.ca).
AB - A 50 MHz array-based imaging system was used to obtain high-resolution images of the ear and auditory system. This previously described custom built imaging system (Brown et al. 2004a, 2004b; Brown and Lockwood 2005) is capable of 50 μm axial resolution, and lateral resolution varying from 80 μm to 130 μm over a 5.12 mm scan depth. The imaging system is based on a 2 mm diameter, seven-element equal-area annular array, and a digital beamformer that uses high-speed field programmable gate arrays (FPGAs). The images produced by this system have shown far superior depth of field compared with commercially available single-element systems. Ex vivo, three-dimensional (3-D) images were obtained of human cadaveric tissues including the ossicles (stapes, incus, malleus) and the tympanic membrane. In addition, two-dimensional (2-D) images were obtained of an intact cochlea by imaging through the round window membrane. The basilar membrane inside the cochlea could clearly be visualized. These images demonstrate that high-frequency ultrasound imaging of the middle and inner ear can provide valuable diagnostic information using minimally invasive techniques that could potentially be implemented in vivo. (E-mail: J.Brown@dal.ca).
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U2 - 10.1016/j.ultrasmedbio.2009.05.021
DO - 10.1016/j.ultrasmedbio.2009.05.021
M3 - Article
C2 - 19679390
AN - SCOPUS:74249096165
SN - 0301-5629
VL - 35
SP - 1899
EP - 1907
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 11
ER -