Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth

for the BBOP Study Group

doi:10.1016/j.nutres.2021.05.007

Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth

for the BBOP Study Group

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

9 Citas (Scopus)

Resumen

A number of studies have demonstrated that patients with autoimmune disease have lower levels of vitamin D prompting speculation that vitamin D might suppress inflammation and immune responses in children with juvenile idiopathic arthritis (JIA). The objective of this study was to compare vitamin D levels in children with JIA at disease onset with healthy children. We hypothesized that children and adolescents with JIA have lower vitamin D levels than healthy children and adolescents. Data from a Canadian cohort of children with new-onset JIA (n= 164, data collection 2007-2012) were compared to Canadian Health Measures Survey (CHMS) data (n=4027, data collection 2007-2011). We compared 25-hydroxy vitamin D (25(OH)D) concentrations with measures of inflammation, vitamin D supplement use, milk intake, and season of birth. Mean 25(OH)D level was significantly higher in patients with JIA (79 ± 3.1 nmol/L) than in healthy controls (68 ± 1.8 nmol/L P <.05). Patients with JIA more often used vitamin D containing supplements (50% vs. 7%; P <.05). The prevalence of 25(OH)D deficiency (<30 nmol/L) was 6% for both groups. Children with JIA with 25(OH)D deficiency or insufficiency (<50 nmol/L) had higher C-reactive protein levels. Children with JIA were more often born in the fall and winter compared to healthy children. In contrast to earlier studies, we found vitamin D levels in Canadian children with JIA were higher compared to healthy children and associated with more frequent use of vitamin D supplements. Among children with JIA, low vitamin D levels were associated with indicators of greater inflammation.

Idioma original	English
Páginas (desde-hasta)	139-149
Número de páginas	11
Publicación	Nutrition Research
Volumen	92
DOI	https://doi.org/10.1016/j.nutres.2021.05.007
Estado	Published - ago. 2021
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
This research was supported by funding from the Canadian Institutes for Health Research (Institute of Musculoskeletal Health and Arthritis and Institute of Infection and Immunity FRN # 82517); The Arthritis Society ; The Canadian Arthritis Network 2006-SRI-IJD-01; The University of Saskatchewan ; The Manitoba Institute of Child Health; McGill University (Division of Pediatric Rheumatology); Memorial University ; The University of British Columbia (Division of Pediatric Rheumatology); The Clinical Research Centre of the Centre Hospitalier Universitaire de Sherbrooke (CHUS); and the Jim Pattison Children's Hospital Foundation . Funder's had no role in the design, analysis or writing of this article.

Publisher Copyright:
© 2021

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Nutrition and Dietetics

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth. / for the BBOP Study Group.
En: Nutrition Research, Vol. 92, 08.2021, p. 139-149.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

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title = "Higher concentrations of vitamin D in Canadian children with juvenile idiopathic arthritis compared to healthy controls are associated with more frequent use of vitamin D supplements and season of birth",

abstract = "A number of studies have demonstrated that patients with autoimmune disease have lower levels of vitamin D prompting speculation that vitamin D might suppress inflammation and immune responses in children with juvenile idiopathic arthritis (JIA). The objective of this study was to compare vitamin D levels in children with JIA at disease onset with healthy children. We hypothesized that children and adolescents with JIA have lower vitamin D levels than healthy children and adolescents. Data from a Canadian cohort of children with new-onset JIA (n= 164, data collection 2007-2012) were compared to Canadian Health Measures Survey (CHMS) data (n=4027, data collection 2007-2011). We compared 25-hydroxy vitamin D (25(OH)D) concentrations with measures of inflammation, vitamin D supplement use, milk intake, and season of birth. Mean 25(OH)D level was significantly higher in patients with JIA (79 ± 3.1 nmol/L) than in healthy controls (68 ± 1.8 nmol/L P <.05). Patients with JIA more often used vitamin D containing supplements (50% vs. 7%; P <.05). The prevalence of 25(OH)D deficiency (<30 nmol/L) was 6% for both groups. Children with JIA with 25(OH)D deficiency or insufficiency (<50 nmol/L) had higher C-reactive protein levels. Children with JIA were more often born in the fall and winter compared to healthy children. In contrast to earlier studies, we found vitamin D levels in Canadian children with JIA were higher compared to healthy children and associated with more frequent use of vitamin D supplements. Among children with JIA, low vitamin D levels were associated with indicators of greater inflammation.",

author = "{for the BBOP Study Group} and Finch, {Sarah L.} and Rosenberg, {Alan M.} and Kusalik, {Anthony J.} and Farhad Maleki and Elham Rezaei and Adam Baxter-Jones and Susanne Benseler and Gilles Boire and David Cabral and Sarah Campillo and Ga{\"e}lle Ch{\'e}deville and Chetaille, {Anne Laure} and Paul Dancey and Ciaran Duffy and Duffy, {Karen Watanabe} and Jaime Guzman and Kristin Houghton and Huber, {Adam M.} and Roman Jurencak and Bianca Lang and Laxer, {Ron M.} and Kimberly Morishita and Oen, {Kiem G.} and Petty, {Ross E.} and Ramsey, {Suzanne E.} and Johannes Roth and Rayfel Schneider and Rosie Scuccimarri and Elizabeth Stringer and Tse, {Shirley M.L.} and Tucker, {Lori B.} and Turvey, {Stuart E.} and Michael Szafron and Susan Whiting and Yeung, {Rae SM} and Hassan Vatanparast",

note = "Funding Information: This research was supported by funding from the Canadian Institutes for Health Research (Institute of Musculoskeletal Health and Arthritis and Institute of Infection and Immunity FRN # 82517); The Arthritis Society ; The Canadian Arthritis Network 2006-SRI-IJD-01; The University of Saskatchewan ; The Manitoba Institute of Child Health; McGill University (Division of Pediatric Rheumatology); Memorial University ; The University of British Columbia (Division of Pediatric Rheumatology); The Clinical Research Centre of the Centre Hospitalier Universitaire de Sherbrooke (CHUS); and the Jim Pattison Children's Hospital Foundation . Funder's had no role in the design, analysis or writing of this article. Publisher Copyright: {\textcopyright} 2021",

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AU - Kusalik, Anthony J.

AU - Maleki, Farhad

AU - Rezaei, Elham

AU - Baxter-Jones, Adam

AU - Benseler, Susanne

AU - Boire, Gilles

AU - Cabral, David

AU - Campillo, Sarah

AU - Chédeville, Gaëlle

AU - Chetaille, Anne Laure

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AU - Duffy, Ciaran

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AU - Houghton, Kristin

AU - Huber, Adam M.

AU - Jurencak, Roman

AU - Lang, Bianca

AU - Laxer, Ron M.

AU - Morishita, Kimberly

AU - Oen, Kiem G.

AU - Petty, Ross E.

AU - Ramsey, Suzanne E.

AU - Roth, Johannes

AU - Schneider, Rayfel

AU - Scuccimarri, Rosie

AU - Stringer, Elizabeth

AU - Tse, Shirley M.L.

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AU - Vatanparast, Hassan

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PY - 2021/8

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N2 - A number of studies have demonstrated that patients with autoimmune disease have lower levels of vitamin D prompting speculation that vitamin D might suppress inflammation and immune responses in children with juvenile idiopathic arthritis (JIA). The objective of this study was to compare vitamin D levels in children with JIA at disease onset with healthy children. We hypothesized that children and adolescents with JIA have lower vitamin D levels than healthy children and adolescents. Data from a Canadian cohort of children with new-onset JIA (n= 164, data collection 2007-2012) were compared to Canadian Health Measures Survey (CHMS) data (n=4027, data collection 2007-2011). We compared 25-hydroxy vitamin D (25(OH)D) concentrations with measures of inflammation, vitamin D supplement use, milk intake, and season of birth. Mean 25(OH)D level was significantly higher in patients with JIA (79 ± 3.1 nmol/L) than in healthy controls (68 ± 1.8 nmol/L P <.05). Patients with JIA more often used vitamin D containing supplements (50% vs. 7%; P <.05). The prevalence of 25(OH)D deficiency (<30 nmol/L) was 6% for both groups. Children with JIA with 25(OH)D deficiency or insufficiency (<50 nmol/L) had higher C-reactive protein levels. Children with JIA were more often born in the fall and winter compared to healthy children. In contrast to earlier studies, we found vitamin D levels in Canadian children with JIA were higher compared to healthy children and associated with more frequent use of vitamin D supplements. Among children with JIA, low vitamin D levels were associated with indicators of greater inflammation.

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