Host factors and measles virus replication

Sebastien Delpeut; Ryan S. Noyce; Ricky Wc Siu; Christopher D. Richardson

doi:10.1016/j.coviro.2012.10.008

Host factors and measles virus replication

Sebastien Delpeut, Ryan S. Noyce, Ricky Wc Siu, Christopher D. Richardson

Medicine

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44 Citas (Scopus)

Resumen

This review takes a general approach to describing host cell factors that facilitate measles virus (MeV) infection and replication. It relates our current understanding of MeV entry receptors, with emphasis on how these host cell surface proteins contribute to pathogenesis within its host. The roles of SLAM/CD150 lymphocyte receptor and the newly discovered epithelial receptor PVRL4/nectin-4 are highlighted. Host cell factors such as HSP72, Prdx1, tubulin, casein kinase, and actin, which are known to impact viral RNA synthesis and virion assembly, are also discussed. Finally the review describes strategies used by measles virus to circumvent innate immunity and confound the effects of interferon within the host cell. Proteomic studies and genome wide RNAi screens will undoubtedly advance our knowledge in the future.

Idioma original	English
Páginas (desde-hasta)	773-783
Número de páginas	11
Publicación	Current Opinion in Virology
Volumen	2
N.º	6
DOI	https://doi.org/10.1016/j.coviro.2012.10.008
Estado	Published - dic. 2012

Nota bibliográfica

Funding Information:
This work was supported by grants from the Canadian Institute for Health Research ( CIHR MOP 10638 ; CIHR MOP 114949 ) and Nova Scotia Health Research Foundation (Grant # 1200 ). C.D.R. is a Canada Research Chair (Tier I) in Vaccinology and Viral Therapeutics. R.S.N. is supported by a CIHR Banting Postdoctoral Fellowship and held a trainee award from the Beatrice Hunter Cancer Research Institute with funds provided by the Canadian Breast Cancer Foundation – Atlantic Region as part of The Terry Fox Strategic Health Research Training Program in Cancer Research in CIHR.

ASJC Scopus Subject Areas

Virology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Review

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title = "Host factors and measles virus replication",

abstract = "This review takes a general approach to describing host cell factors that facilitate measles virus (MeV) infection and replication. It relates our current understanding of MeV entry receptors, with emphasis on how these host cell surface proteins contribute to pathogenesis within its host. The roles of SLAM/CD150 lymphocyte receptor and the newly discovered epithelial receptor PVRL4/nectin-4 are highlighted. Host cell factors such as HSP72, Prdx1, tubulin, casein kinase, and actin, which are known to impact viral RNA synthesis and virion assembly, are also discussed. Finally the review describes strategies used by measles virus to circumvent innate immunity and confound the effects of interferon within the host cell. Proteomic studies and genome wide RNAi screens will undoubtedly advance our knowledge in the future.",

author = "Sebastien Delpeut and Noyce, {Ryan S.} and Siu, {Ricky Wc} and Richardson, {Christopher D.}",

note = "Funding Information: This work was supported by grants from the Canadian Institute for Health Research ( CIHR MOP 10638 ; CIHR MOP 114949 ) and Nova Scotia Health Research Foundation (Grant # 1200 ). C.D.R. is a Canada Research Chair (Tier I) in Vaccinology and Viral Therapeutics. R.S.N. is supported by a CIHR Banting Postdoctoral Fellowship and held a trainee award from the Beatrice Hunter Cancer Research Institute with funds provided by the Canadian Breast Cancer Foundation – Atlantic Region as part of The Terry Fox Strategic Health Research Training Program in Cancer Research in CIHR. ",

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doi = "10.1016/j.coviro.2012.10.008",

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AU - Delpeut, Sebastien

AU - Noyce, Ryan S.

AU - Siu, Ricky Wc

AU - Richardson, Christopher D.

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Host factors and measles virus replication

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

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