TY - JOUR
T1 - Hyperalgesia produced by intrathecal substance P and related peptides
T2 - desensitization and cross desensitization
AU - Moochhala, S. M.
AU - Sawynok, J.
PY - 1984/6
Y1 - 1984/6
N2 - The hyperalgesic effect of intrathecally administered substance P (SP), physalaemin, eledoisin and eledoisin‐related peptide (ERP) was investigated in the rat tail flick test. Hyperalgesia produced by SP (2.5–15 μg, 1.9–11 nmol) was maximal 10–20 min after injection, lasted 30 min and was dose‐related. The effect was mimicked by all of the peptides examined. The rank order of potency was physalaemin > SP > eledoisin > ERP. Desensitization to the hyperalgesic effect of SP was produced by three repeated intrathecal injections. Rats desensitized to SP no longer responded to physalaemin or ERP, indicating cross‐desensitization. Phentolamine continued to produce hyperalgesia following such desensitization. The demonstration of a hyperalgesic effect for SP provides further support for a role for SP in nociceptive transmission. The receptor mediating this effect appears to be a SP‐P subtype. Cross‐desensitization between peptides suggests an action on the same receptor. 1984 British Pharmacological Society
AB - The hyperalgesic effect of intrathecally administered substance P (SP), physalaemin, eledoisin and eledoisin‐related peptide (ERP) was investigated in the rat tail flick test. Hyperalgesia produced by SP (2.5–15 μg, 1.9–11 nmol) was maximal 10–20 min after injection, lasted 30 min and was dose‐related. The effect was mimicked by all of the peptides examined. The rank order of potency was physalaemin > SP > eledoisin > ERP. Desensitization to the hyperalgesic effect of SP was produced by three repeated intrathecal injections. Rats desensitized to SP no longer responded to physalaemin or ERP, indicating cross‐desensitization. Phentolamine continued to produce hyperalgesia following such desensitization. The demonstration of a hyperalgesic effect for SP provides further support for a role for SP in nociceptive transmission. The receptor mediating this effect appears to be a SP‐P subtype. Cross‐desensitization between peptides suggests an action on the same receptor. 1984 British Pharmacological Society
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U2 - 10.1111/j.1476-5381.1984.tb10773.x
DO - 10.1111/j.1476-5381.1984.tb10773.x
M3 - Article
C2 - 6203593
AN - SCOPUS:0021277125
SN - 0007-1188
VL - 82
SP - 381
EP - 388
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
IS - 2
ER -