In tendons, differing physiological requirements lead to functionally distinct nanostructures

Andrew S. Quigley, Stéphane Bancelin, Dylan Deska-Gauthier, François Légaré, Laurent Kreplak, Samuel P. Veres

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

54 Citas (Scopus)

Resumen

The collagen-based tissues of animals are hierarchical structures: even tendon, the simplest collagenous tissue, has seven to eight levels of hierarchy. Tailoring tissue structure to match physiological function can occur at many different levels. We wanted to know if the control of tissue architecture to achieve function extends down to the nanoscale level of the individual, cable-like collagen fibrils. Using tendons from young adult bovine forelimbs, we performed stress-strain experiments on single collagen fibrils extracted from tendons with positional function, and tendons with energy storing function. Collagen fibrils from the two tendon types, which have known differences in intermolecular crosslinking, showed numerous differences in their responses to elongation. Unlike those from positional tendons, fibrils from energy storing tendons showed high strain stiffening and resistance to disruption in both molecular packing and conformation, helping to explain how these high stress tissues withstand millions of loading cycles with little reparative remodeling. Functional differences in load-bearing tissues are accompanied by important differences in nanoscale collagen fibril structure.

Idioma originalEnglish
Número de artículo4409
PublicaciónScientific Reports
Volumen8
N.º1
DOI
EstadoPublished - dic. 1 2018

Nota bibliográfica

Funding Information:
This work was supported by grants to SPV and LK from the Natural Sciences and Engineering Research Council of Canada (NSERC).

Publisher Copyright:
© 2018 The Author(s).

ASJC Scopus Subject Areas

  • General

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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