TY - JOUR
T1 - Increase in Serum Uric Acid Level Associated With Cisplatin Therapy
T2 - Correlation With Liver but Not Kidney Platinum Concentrations
AU - Nanji, Amin A.
AU - Mikhael, Nadia Z.
AU - Stewart, David J.
PY - 1985/11
Y1 - 1985/11
N2 - Hyperuricemia associated with cisplatin therapy is considered to be a consequence of cisplatin-induced nephrotoxic reactions. We correlated changes in serum uric acid levels in patients with malignant neoplasms with tissue levels of platinum and the total dose of cisplatin. In 15 patients, the serum uric acid level increased from 6.1± 1.0 mg/dL to 8.3 ±1.3 mg/dL during the time they were receiving cisplatin therapy. The change in uric acid level from baseline to peak correlated with both the total dose of cisplatin and the liver platinum concentration. There was no correlation with platinum concentration in the renal cortex and medulla.
AB - Hyperuricemia associated with cisplatin therapy is considered to be a consequence of cisplatin-induced nephrotoxic reactions. We correlated changes in serum uric acid levels in patients with malignant neoplasms with tissue levels of platinum and the total dose of cisplatin. In 15 patients, the serum uric acid level increased from 6.1± 1.0 mg/dL to 8.3 ±1.3 mg/dL during the time they were receiving cisplatin therapy. The change in uric acid level from baseline to peak correlated with both the total dose of cisplatin and the liver platinum concentration. There was no correlation with platinum concentration in the renal cortex and medulla.
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U2 - 10.1001/archinte.1985.00360110083019
DO - 10.1001/archinte.1985.00360110083019
M3 - Article
C2 - 4062451
AN - SCOPUS:0022387710
SN - 0003-9926
VL - 145
SP - 2013
EP - 2014
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 11
ER -