Influence of warfarin on symptoms of fatigue: Findings of a randomized trial

Michael J. Kovacs; Clive Kearon; Jim A. Julian; James D. Douketis; Christine Demers; Philip S. Wells; Alexander G. Turpie; David R. Anderson; Susan R. Kahn; Paul V. Nguyen; David Green; Jeannine Kassis; William Geerts; Betsy MacKinnon; Jeffrey S. Ginsberg

doi:10.1345/aph.1E531

Influence of warfarin on symptoms of fatigue: Findings of a randomized trial

Michael J. Kovacs, Clive Kearon, Jim A. Julian, James D. Douketis, Christine Demers, Philip S. Wells, Alexander G. Turpie, David R. Anderson, Susan R. Kahn, Paul V. Nguyen, David Green, Jeannine Kassis, William Geerts, Betsy MacKinnon, Jeffrey S. Ginsberg

Medicine

Medicine

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Resumen

BACKGROUND: Some patients develop fatigue while taking warfarin, but causality is uncertain. OBJECTIVE: To assess whether warfarin use is associated with fatigue. METHODS: This investigation was a substudy of a randomized double-blind trial in 13 outpatient thromboembolism clinics. Subjects who had received one month of open-label warfarin therapy for venous thromboembolism due to a transient risk factor were randomly assigned to receive warfarin or placebo for 2 months and followed for another 9 months after stopping the study drug. Fatigue was measured using a Likert scale, and change of fatigue was measured by the patient's global rating. RESULTS: In 87 subjects, the overall ratings of fatigue were 0.1 unit lower (95% CI 0.6 units lower to 0.4 units higher) while taking warfarin. Global rating for change in fatigue intensity showed no increase of fatigue with warfarin use. CONCLUSIONS: The short-term use of warfarin was not associated with symptoms of fatigue.

Idioma original	English
Páginas (desde-hasta)	840-842
Número de páginas	3
Publicación	Annals of Pharmacotherapy
Volumen	39
N.º	5
DOI	https://doi.org/10.1345/aph.1E531
Estado	Published - may. 2005

ASJC Scopus Subject Areas

Pharmacology (medical)

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Kovacs, M. J., Kearon, C., Julian, J. A., Douketis, J. D., Demers, C., Wells, P. S., Turpie, A. G., Anderson, D. R., Kahn, S. R., Nguyen, P. V., Green, D., Kassis, J., Geerts, W., MacKinnon, B., & Ginsberg, J. S. (2005). Influence of warfarin on symptoms of fatigue: Findings of a randomized trial. Annals of Pharmacotherapy, 39(5), 840-842. https://doi.org/10.1345/aph.1E531

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abstract = "BACKGROUND: Some patients develop fatigue while taking warfarin, but causality is uncertain. OBJECTIVE: To assess whether warfarin use is associated with fatigue. METHODS: This investigation was a substudy of a randomized double-blind trial in 13 outpatient thromboembolism clinics. Subjects who had received one month of open-label warfarin therapy for venous thromboembolism due to a transient risk factor were randomly assigned to receive warfarin or placebo for 2 months and followed for another 9 months after stopping the study drug. Fatigue was measured using a Likert scale, and change of fatigue was measured by the patient's global rating. RESULTS: In 87 subjects, the overall ratings of fatigue were 0.1 unit lower (95% CI 0.6 units lower to 0.4 units higher) while taking warfarin. Global rating for change in fatigue intensity showed no increase of fatigue with warfarin use. CONCLUSIONS: The short-term use of warfarin was not associated with symptoms of fatigue.",

author = "Kovacs, {Michael J.} and Clive Kearon and Julian, {Jim A.} and Douketis, {James D.} and Christine Demers and Wells, {Philip S.} and Turpie, {Alexander G.} and Anderson, {David R.} and Kahn, {Susan R.} and Nguyen, {Paul V.} and David Green and Jeannine Kassis and William Geerts and Betsy MacKinnon and Ginsberg, {Jeffrey S.}",

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AU - Demers, Christine

AU - Wells, Philip S.

AU - Turpie, Alexander G.

AU - Anderson, David R.

AU - Kahn, Susan R.

AU - Nguyen, Paul V.

AU - Green, David

AU - Kassis, Jeannine

AU - Geerts, William

AU - MacKinnon, Betsy

AU - Ginsberg, Jeffrey S.

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AB - BACKGROUND: Some patients develop fatigue while taking warfarin, but causality is uncertain. OBJECTIVE: To assess whether warfarin use is associated with fatigue. METHODS: This investigation was a substudy of a randomized double-blind trial in 13 outpatient thromboembolism clinics. Subjects who had received one month of open-label warfarin therapy for venous thromboembolism due to a transient risk factor were randomly assigned to receive warfarin or placebo for 2 months and followed for another 9 months after stopping the study drug. Fatigue was measured using a Likert scale, and change of fatigue was measured by the patient's global rating. RESULTS: In 87 subjects, the overall ratings of fatigue were 0.1 unit lower (95% CI 0.6 units lower to 0.4 units higher) while taking warfarin. Global rating for change in fatigue intensity showed no increase of fatigue with warfarin use. CONCLUSIONS: The short-term use of warfarin was not associated with symptoms of fatigue.

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Influence of warfarin on symptoms of fatigue: Findings of a randomized trial

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