Influenza in children with cancer

Allison Kempe; Caroline B. Hall; Noni E. MacDonald; Howard R. Foye; Kathleen A. Woodin; Harvey J. Cohen; Edward D. Lewis; Michelle Gullace; Christine L. Gala; Corinne S. Dulberg; Emmanuel Katsanis

doi:10.1016/S0022-3476(89)80325-7

Influenza in children with cancer

Allison Kempe, Caroline B. Hall, Noni E. MacDonald, Howard R. Foye, Kathleen A. Woodin, Harvey J. Cohen, Edward D. Lewis, Michelle Gullace, Christine L. Gala, Corinne S. Dulberg, Emmanuel Katsanis

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111 Citas (Scopus)

Resumen

We prospectively followed a group of unimmunized, immunosuppressed children with cancer to determine their relative risk of influenza and the severity of infection compared with those of siblings or matched community controls. The incidence of influenza infection was higher in children with cancer (23/73, 32%) than in control subjects (10/70, 14%, p=0.02). A preseason hemagglutination inhibition titer≥1:32, generally used as a marker of successful immunization in vaccine trials, was protective for all children in the control groups, but did not prevent influenza infection in 24% of the patients with cancer. Infection rates of patients and community controls with titers ≥1:32 differed significantly (p=0.006). No significant differences were noted in duration of reported symptoms between groups, and clinical complications occurred too infrequently to analyze. However, 2 (11%) of 18 of the cancer patients with positive culture results were hospitalized during the illness and one patient developed a nosocomial infection. None of the control children was hospitalized. These findings suggest the need for further study of the immunologic response of immunosuppressed children to influenza infection and a clinical efficacy trial of the influenza vaccine in these patients.

Idioma original	English
Páginas (desde-hasta)	33-39
Número de páginas	7
Publicación	Journal of Pediatrics
Volumen	115
N.º	1
DOI	https://doi.org/10.1016/S0022-3476(89)80325-7
Estado	Published - jul. 1989
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
The Committee on Infectious Diseases of the American Academy of Pediatrics currently recommends yearly vaccination against influenza for children considered at high risk of increased morbidity or death after influenza infection. 1 Those targeted as being most likely to benefit from yearly immunization include children with conditions requiring immunosuppressive therapy. These recommendations for children have, for many years, mirrored those Supported by grants from the Robert Wood Johnson Foundation, The Thrasher Foundation, The Cancer Council of the United Way, and the Ontario Thoracic Society. The research was Undertaken by Dr. Kempe in partial fulfillment of the requirements of a master of science degree in Community Health, Department of Preventive Medicine, University of Rochester. Submitted for publication Oct. 31, 1988; accepted Jan. 4, 1989. Reprint requests: Allison Kempe, MD, Comprehensive Child Health Program, Children's Hospital, 300 Longwood Ave., Boston, MA 02115.

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health

ODS de las Naciones Unidas

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@article{c19d5a8cb7314116a257e449ab6c0d95,

title = "Influenza in children with cancer",

abstract = "We prospectively followed a group of unimmunized, immunosuppressed children with cancer to determine their relative risk of influenza and the severity of infection compared with those of siblings or matched community controls. The incidence of influenza infection was higher in children with cancer (23/73, 32%) than in control subjects (10/70, 14%, p=0.02). A preseason hemagglutination inhibition titer≥1:32, generally used as a marker of successful immunization in vaccine trials, was protective for all children in the control groups, but did not prevent influenza infection in 24% of the patients with cancer. Infection rates of patients and community controls with titers ≥1:32 differed significantly (p=0.006). No significant differences were noted in duration of reported symptoms between groups, and clinical complications occurred too infrequently to analyze. However, 2 (11%) of 18 of the cancer patients with positive culture results were hospitalized during the illness and one patient developed a nosocomial infection. None of the control children was hospitalized. These findings suggest the need for further study of the immunologic response of immunosuppressed children to influenza infection and a clinical efficacy trial of the influenza vaccine in these patients.",

author = "Allison Kempe and Hall, {Caroline B.} and MacDonald, {Noni E.} and Foye, {Howard R.} and Woodin, {Kathleen A.} and Cohen, {Harvey J.} and Lewis, {Edward D.} and Michelle Gullace and Gala, {Christine L.} and Dulberg, {Corinne S.} and Emmanuel Katsanis",

note = "Funding Information: The Committee on Infectious Diseases of the American Academy of Pediatrics currently recommends yearly vaccination against influenza for children considered at high risk of increased morbidity or death after influenza infection. 1 Those targeted as being most likely to benefit from yearly immunization include children with conditions requiring immunosuppressive therapy. These recommendations for children have, for many years, mirrored those Supported by grants from the Robert Wood Johnson Foundation, The Thrasher Foundation, The Cancer Council of the United Way, and the Ontario Thoracic Society. The research was Undertaken by Dr. Kempe in partial fulfillment of the requirements of a master of science degree in Community Health, Department of Preventive Medicine, University of Rochester. Submitted for publication Oct. 31, 1988; accepted Jan. 4, 1989. Reprint requests: Allison Kempe, MD, Comprehensive Child Health Program, Children's Hospital, 300 Longwood Ave., Boston, MA 02115.",

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AU - Hall, Caroline B.

AU - MacDonald, Noni E.

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AU - Woodin, Kathleen A.

AU - Cohen, Harvey J.

AU - Lewis, Edward D.

AU - Gullace, Michelle

AU - Gala, Christine L.

AU - Dulberg, Corinne S.

AU - Katsanis, Emmanuel

N1 - Funding Information: The Committee on Infectious Diseases of the American Academy of Pediatrics currently recommends yearly vaccination against influenza for children considered at high risk of increased morbidity or death after influenza infection. 1 Those targeted as being most likely to benefit from yearly immunization include children with conditions requiring immunosuppressive therapy. These recommendations for children have, for many years, mirrored those Supported by grants from the Robert Wood Johnson Foundation, The Thrasher Foundation, The Cancer Council of the United Way, and the Ontario Thoracic Society. The research was Undertaken by Dr. Kempe in partial fulfillment of the requirements of a master of science degree in Community Health, Department of Preventive Medicine, University of Rochester. Submitted for publication Oct. 31, 1988; accepted Jan. 4, 1989. Reprint requests: Allison Kempe, MD, Comprehensive Child Health Program, Children's Hospital, 300 Longwood Ave., Boston, MA 02115.

PY - 1989/7

Y1 - 1989/7

N2 - We prospectively followed a group of unimmunized, immunosuppressed children with cancer to determine their relative risk of influenza and the severity of infection compared with those of siblings or matched community controls. The incidence of influenza infection was higher in children with cancer (23/73, 32%) than in control subjects (10/70, 14%, p=0.02). A preseason hemagglutination inhibition titer≥1:32, generally used as a marker of successful immunization in vaccine trials, was protective for all children in the control groups, but did not prevent influenza infection in 24% of the patients with cancer. Infection rates of patients and community controls with titers ≥1:32 differed significantly (p=0.006). No significant differences were noted in duration of reported symptoms between groups, and clinical complications occurred too infrequently to analyze. However, 2 (11%) of 18 of the cancer patients with positive culture results were hospitalized during the illness and one patient developed a nosocomial infection. None of the control children was hospitalized. These findings suggest the need for further study of the immunologic response of immunosuppressed children to influenza infection and a clinical efficacy trial of the influenza vaccine in these patients.

AB - We prospectively followed a group of unimmunized, immunosuppressed children with cancer to determine their relative risk of influenza and the severity of infection compared with those of siblings or matched community controls. The incidence of influenza infection was higher in children with cancer (23/73, 32%) than in control subjects (10/70, 14%, p=0.02). A preseason hemagglutination inhibition titer≥1:32, generally used as a marker of successful immunization in vaccine trials, was protective for all children in the control groups, but did not prevent influenza infection in 24% of the patients with cancer. Infection rates of patients and community controls with titers ≥1:32 differed significantly (p=0.006). No significant differences were noted in duration of reported symptoms between groups, and clinical complications occurred too infrequently to analyze. However, 2 (11%) of 18 of the cancer patients with positive culture results were hospitalized during the illness and one patient developed a nosocomial infection. None of the control children was hospitalized. These findings suggest the need for further study of the immunologic response of immunosuppressed children to influenza infection and a clinical efficacy trial of the influenza vaccine in these patients.

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Influenza in children with cancer

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ASJC Scopus Subject Areas

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