Inhibition of transient receptor potential channel mucolipin-1 (TRPML1) by lysosomal adenosine involved in severe combined immunodeficiency diseases

Medicine & Life Sciences

• Adenosine 75%
• Adenosine Deaminase 24%
• adenosine transporter 17%
• Adenosine Triphosphate 7%
• B-Lymphocytes 14%
• Cell Death 7%
• Enzymes 5%
• Homeostasis 7%
• Lysosomes 48%
• Membranes 5%
• Mutation 5%
• Nucleic Acids 9%
• Oxidative Stress 7%
• Recycling 11%
• Severe Combined Immunodeficiency 98%
• Severe combined immunodeficiency due to adenosine deaminase deficiency 15%
• Therapeutics 1%
• Transient Receptor Potential Channels 100%

Chemical Compounds

• Adenosine 73%
• Cell Death 6%
• Mutation 5%
• Nucleic Acid 5%
• Oxidative Stress 6%
• Recycling 5%