Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults

R. Hasler; M. G. Preti; D. E. Meskaldji; J. Prados; W. Adouan; C. Rodriguez; S. Toma; N. Hiller; T. Ismaili; J. Hofmeister; I. Sinanaj; P. Baud; S. Haller; P. Giannakopoulos; S. Schwartz; N. Perroud; D. Van De Ville

doi:10.1016/j.pscychresns.2017.09.004

Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults

R. Hasler, M. G. Preti, D. E. Meskaldji, J. Prados, W. Adouan, C. Rodriguez, S. Toma, N. Hiller, T. Ismaili, J. Hofmeister, I. Sinanaj, P. Baud, S. Haller, P. Giannakopoulos, S. Schwartz, N. Perroud, D. Van De Ville

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17 Citas (Scopus)

Resumen

Attention deficit hyperactivity disorder (ADHD) is accompanied by resting-state alterations, including abnormal activity, connectivity and asymmetry of the default-mode network (DMN). Concurrently, recent studies suggested a link between ADHD and the presence of polymorphisms within the gene BAIAP2 (i.e., brain-specific angiogenesis inhibitor 1-associated protein 2), known to be differentially expressed in brain hemispheres. The clinical and neuroimaging correlates of this polymorphism are still unknown. We investigated the association between BAIAP2 polymorphisms and DMN functional connectivity (FC) asymmetry as well as behavioral measures in ADHD adults. Resting-state fMRI was acquired from 30 ADHD and 15 healthy adults. For each subject, rs7210438 and rs8079626 within the gene BAIAP2 were genotyped. ADHD severity, impulsiveness and anger were assessed for the ADHD group. Using multivariate analysis of variance, we found that genetic features do have an impact on DMN FC asymmetry. In particular, polymorphism rs8079626 affects medial frontal gyrus and inferior parietal lobule connectivity asymmetry, lower for AA than AG/GG carriers. Further, when combining FC asymmetry and the presence of the rs8079626 variant, we successfully predicted increased externalization of anger in ADHD. In conclusion, a complex interplay between genetic vulnerability and inter-hemispherical DMN FC asymmetry plays a role in emotion regulation in adult ADHD.

Idioma original	English
Páginas (desde-hasta)	54-61
Número de páginas	8
Publicación	Psychiatry Research - Neuroimaging
Volumen	269
DOI	https://doi.org/10.1016/j.pscychresns.2017.09.004
Estado	Published - nov. 30 2017
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
This work was supported in part by the Swiss National Science Foundation (Grant nos. PP00P2-146318 to DVDV and 320030_135653 to SS), the National Center of Competence in Research (NCCR) Affective Sciences financed by the Swiss National Science Foundation (No. 51NF40-104897 ), and in part by the Center for Biomedical Imaging (CIBM).

Publisher Copyright:
© 2017

ASJC Scopus Subject Areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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Hasler, R., Preti, M. G., Meskaldji, D. E., Prados, J., Adouan, W., Rodriguez, C., Toma, S., Hiller, N., Ismaili, T., Hofmeister, J., Sinanaj, I., Baud, P., Haller, S., Giannakopoulos, P., Schwartz, S., Perroud, N., & Van De Ville, D. (2017). Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults. Psychiatry Research - Neuroimaging, 269, 54-61. https://doi.org/10.1016/j.pscychresns.2017.09.004

Hasler, R, Preti, MG, Meskaldji, DE, Prados, J, Adouan, W, Rodriguez, C, Toma, S, Hiller, N, Ismaili, T, Hofmeister, J, Sinanaj, I, Baud, P, Haller, S, Giannakopoulos, P, Schwartz, S, Perroud, N & Van De Ville, D 2017, 'Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults', Psychiatry Research - Neuroimaging, vol. 269, pp. 54-61. https://doi.org/10.1016/j.pscychresns.2017.09.004

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title = "Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults",

abstract = "Attention deficit hyperactivity disorder (ADHD) is accompanied by resting-state alterations, including abnormal activity, connectivity and asymmetry of the default-mode network (DMN). Concurrently, recent studies suggested a link between ADHD and the presence of polymorphisms within the gene BAIAP2 (i.e., brain-specific angiogenesis inhibitor 1-associated protein 2), known to be differentially expressed in brain hemispheres. The clinical and neuroimaging correlates of this polymorphism are still unknown. We investigated the association between BAIAP2 polymorphisms and DMN functional connectivity (FC) asymmetry as well as behavioral measures in ADHD adults. Resting-state fMRI was acquired from 30 ADHD and 15 healthy adults. For each subject, rs7210438 and rs8079626 within the gene BAIAP2 were genotyped. ADHD severity, impulsiveness and anger were assessed for the ADHD group. Using multivariate analysis of variance, we found that genetic features do have an impact on DMN FC asymmetry. In particular, polymorphism rs8079626 affects medial frontal gyrus and inferior parietal lobule connectivity asymmetry, lower for AA than AG/GG carriers. Further, when combining FC asymmetry and the presence of the rs8079626 variant, we successfully predicted increased externalization of anger in ADHD. In conclusion, a complex interplay between genetic vulnerability and inter-hemispherical DMN FC asymmetry plays a role in emotion regulation in adult ADHD.",

author = "R. Hasler and Preti, {M. G.} and Meskaldji, {D. E.} and J. Prados and W. Adouan and C. Rodriguez and S. Toma and N. Hiller and T. Ismaili and J. Hofmeister and I. Sinanaj and P. Baud and S. Haller and P. Giannakopoulos and S. Schwartz and N. Perroud and {Van De Ville}, D.",

note = "Funding Information: This work was supported in part by the Swiss National Science Foundation (Grant nos. PP00P2-146318 to DVDV and 320030_135653 to SS), the National Center of Competence in Research (NCCR) Affective Sciences financed by the Swiss National Science Foundation (No. 51NF40-104897 ), and in part by the Center for Biomedical Imaging (CIBM). Publisher Copyright: {\textcopyright} 2017",

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T1 - Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults

AU - Hasler, R.

AU - Preti, M. G.

AU - Meskaldji, D. E.

AU - Prados, J.

AU - Adouan, W.

AU - Rodriguez, C.

AU - Toma, S.

AU - Hiller, N.

AU - Ismaili, T.

AU - Hofmeister, J.

AU - Sinanaj, I.

AU - Baud, P.

AU - Haller, S.

AU - Giannakopoulos, P.

AU - Schwartz, S.

AU - Perroud, N.

AU - Van De Ville, D.

N1 - Funding Information: This work was supported in part by the Swiss National Science Foundation (Grant nos. PP00P2-146318 to DVDV and 320030_135653 to SS), the National Center of Competence in Research (NCCR) Affective Sciences financed by the Swiss National Science Foundation (No. 51NF40-104897 ), and in part by the Center for Biomedical Imaging (CIBM). Publisher Copyright: © 2017

PY - 2017/11/30

Y1 - 2017/11/30

N2 - Attention deficit hyperactivity disorder (ADHD) is accompanied by resting-state alterations, including abnormal activity, connectivity and asymmetry of the default-mode network (DMN). Concurrently, recent studies suggested a link between ADHD and the presence of polymorphisms within the gene BAIAP2 (i.e., brain-specific angiogenesis inhibitor 1-associated protein 2), known to be differentially expressed in brain hemispheres. The clinical and neuroimaging correlates of this polymorphism are still unknown. We investigated the association between BAIAP2 polymorphisms and DMN functional connectivity (FC) asymmetry as well as behavioral measures in ADHD adults. Resting-state fMRI was acquired from 30 ADHD and 15 healthy adults. For each subject, rs7210438 and rs8079626 within the gene BAIAP2 were genotyped. ADHD severity, impulsiveness and anger were assessed for the ADHD group. Using multivariate analysis of variance, we found that genetic features do have an impact on DMN FC asymmetry. In particular, polymorphism rs8079626 affects medial frontal gyrus and inferior parietal lobule connectivity asymmetry, lower for AA than AG/GG carriers. Further, when combining FC asymmetry and the presence of the rs8079626 variant, we successfully predicted increased externalization of anger in ADHD. In conclusion, a complex interplay between genetic vulnerability and inter-hemispherical DMN FC asymmetry plays a role in emotion regulation in adult ADHD.

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Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults

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