Interactions of CDKAL1 rs7747752 polymorphism and serum levels of L-carnitine and choline are related to increased risk of gestational diabetes mellitus

Hui Wang, Jing Li, Jinnan Liu, Junhong Leng, Weiqin Li, Zhijie Yu, Claudia H.T. Tam, Gang Hu, Ronald C.W. Ma, Zhongze Fang, Ying Wang, Xilin Yang

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

Background: Interactions between genetic, metabolic, and environmental factors lead to gestational diabetes mellitus (GDM). We aimed to examine interactive effects of cyclin-dependent kinase 5 regulatory subunit-associated protein1-like 1(CDKAL1) rs7747752 polymorphism with low serum levels of L-carnitine, choline, and betaine for GDM. Methods: A nested case-control study of 207 GDM women and their one-to-one, age-matched controls was organized from a prospective cohort of pregnant women in Tianjin, China. Conditional logistic regressions were used to test associations between CDKAL1 rs7747752 and serum levels of L-carnitine, choline, and betaine, and the risk of GDM. Additive interactions were performed to examine interactive effects of rs7747752 and low serum levels of L-carnitine, choline, and betaine on the risk of GDM. Results: The CDKAL1 rs7747752 G > C was associated with GDM in additive, dominant, and recessive model (P <0.05). The rs7747752 CC genotype enhanced the OR of L-carnitine ≤ vs. > 150 nmol/mL for GDM from 6.14 (2.61–14.4) to 19.6 (5.65–68.1) and the OR of choline ≤ vs. > 110 nmol/mL from 2.37 (1.07–5.28) to 12.1 (3.22–45.6), with significant additive interactions. Similarly, CG genotype also enhanced the OR of L-carnitine ≤ vs. > 150 nmol/mL for GDM from 4.70 (2.01–11.0) to 11.4 (3.98–32.9), with a significant additive interaction. However, the additive interaction between rs7747752 and betaine ≤ 200 nmol/mL on the risk of GDM was not significant. Conclusions: The CC or CG genotype carriers in rs7747752 of CDKAL1 who have a low serum level of L-carnitine or choline are at a particular high risk of GDM. Randomized controlled trials are warranted to test the effect of supplement of L-carnitine or choline on the risk of GDM in the high-risk group.

Idioma originalEnglish
Número de artículo14
PublicaciónGenes and Nutrition
Volumen17
N.º1
DOI
EstadoPublished - dic. 2022

Nota bibliográfica

Funding Information:
This work was supported by the National Natural Science Foundation of China (Grant No: 81870549), the Engaged Talents of Guangdong Medical University in 2017 (Grant No: 2XB17028), the Sailing Plan of Guangdong Province (Grant No: 4YF16001G), and the National Key Research and Development Program of China (Grant No: 2019YFA0802300).

Funding Information:
The authors thank all the health professionals of Tianjin Antenatal Network for their involvement and contribution to the study. X.Y. was the guarantor of this manuscript.

Publisher Copyright:
© 2022, The Author(s).

ASJC Scopus Subject Areas

  • Endocrinology, Diabetes and Metabolism
  • Genetics

PubMed: MeSH publication types

  • Journal Article

Huella

Profundice en los temas de investigación de 'Interactions of CDKAL1 rs7747752 polymorphism and serum levels of L-carnitine and choline are related to increased risk of gestational diabetes mellitus'. En conjunto forman una huella única.

Citar esto