Resumen
Background: Interactions between genetic, metabolic, and environmental factors lead to gestational diabetes mellitus (GDM). We aimed to examine interactive effects of cyclin-dependent kinase 5 regulatory subunit-associated protein1-like 1(CDKAL1) rs7747752 polymorphism with low serum levels of L-carnitine, choline, and betaine for GDM. Methods: A nested case-control study of 207 GDM women and their one-to-one, age-matched controls was organized from a prospective cohort of pregnant women in Tianjin, China. Conditional logistic regressions were used to test associations between CDKAL1 rs7747752 and serum levels of L-carnitine, choline, and betaine, and the risk of GDM. Additive interactions were performed to examine interactive effects of rs7747752 and low serum levels of L-carnitine, choline, and betaine on the risk of GDM. Results: The CDKAL1 rs7747752 G > C was associated with GDM in additive, dominant, and recessive model (P <0.05). The rs7747752 CC genotype enhanced the OR of L-carnitine ≤ vs. > 150 nmol/mL for GDM from 6.14 (2.61–14.4) to 19.6 (5.65–68.1) and the OR of choline ≤ vs. > 110 nmol/mL from 2.37 (1.07–5.28) to 12.1 (3.22–45.6), with significant additive interactions. Similarly, CG genotype also enhanced the OR of L-carnitine ≤ vs. > 150 nmol/mL for GDM from 4.70 (2.01–11.0) to 11.4 (3.98–32.9), with a significant additive interaction. However, the additive interaction between rs7747752 and betaine ≤ 200 nmol/mL on the risk of GDM was not significant. Conclusions: The CC or CG genotype carriers in rs7747752 of CDKAL1 who have a low serum level of L-carnitine or choline are at a particular high risk of GDM. Randomized controlled trials are warranted to test the effect of supplement of L-carnitine or choline on the risk of GDM in the high-risk group.
Idioma original | English |
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Número de artículo | 14 |
Publicación | Genes and Nutrition |
Volumen | 17 |
N.º | 1 |
DOI | |
Estado | Published - dic. 2022 |
Nota bibliográfica
Funding Information:This work was supported by the National Natural Science Foundation of China (Grant No: 81870549), the Engaged Talents of Guangdong Medical University in 2017 (Grant No: 2XB17028), the Sailing Plan of Guangdong Province (Grant No: 4YF16001G), and the National Key Research and Development Program of China (Grant No: 2019YFA0802300).
Funding Information:
The authors thank all the health professionals of Tianjin Antenatal Network for their involvement and contribution to the study. X.Y. was the guarantor of this manuscript.
Publisher Copyright:
© 2022, The Author(s).
ASJC Scopus Subject Areas
- Endocrinology, Diabetes and Metabolism
- Genetics
PubMed: MeSH publication types
- Journal Article