Lifestyle factors and lung cancer risk among never smokers in the Canadian Partnership for Tomorrow’s Health (CanPath)

Rachel A. Murphy; Maryam Darvishian; Jia Qi; Yixian Chen; Quincy Chu; Jennifer Vena; Trevor J.B. Dummer; Nhu Le; Ellen Sweeney; Vanessa DeClercq; Scott A. Grandy; Melanie R. Keats; Yunsong Cui; Philip Awadalla; Darren R. Brenner; Parveen Bhatti

doi:10.1007/s10552-022-01566-x

Lifestyle factors and lung cancer risk among never smokers in the Canadian Partnership for Tomorrow’s Health (CanPath)

Rachel A. Murphy, Maryam Darvishian, Jia Qi, Yixian Chen, Quincy Chu, Jennifer Vena, Trevor J.B. Dummer, Nhu Le, Ellen Sweeney, Vanessa DeClercq, Scott A. Grandy, Melanie R. Keats, Yunsong Cui, Philip Awadalla, Darren R. Brenner, Parveen Bhatti

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

12 Citas (Scopus)

Resumen

Background: Although smoking is the primary risk factor for lung cancer, 15–25% of lung cancers occur in never smokers. Emerging evidence suggests lifestyle factors are associated with lung cancer risk, but few studies among never smokers exist. Methods: A case–control study of never smokers within the Canadian Partnership for Tomorrow’s Health was conducted. At recruitment, participants provided data on lifestyle, health history and sociodemographic factors. Incident lung cancers were identified through linkage with administrative health records. Cases (n = 190) were matched to controls (n = 760) on age, sex, and follow-up time. Logistic regression analyses, adjusted for matching factors and annual income, were used to identify associations between lifestyle factors and lung cancer risk. Results: Consumption of < 5 servings of fruits and vegetables/day was associated with higher risk of lung cancer (OR 1.50, 95% CI 1.03–2.17). Short or long sleep (≤ 6 or > 9 h/night) was also associated with increased risk of lung cancer (OR 1.52, 95% CI 1.01–2.29). No associations were observed for obesity measures, alcohol consumption, or physical activity. Conclusion: Our findings provide evidence of a potential role between sleep, fruits and vegetable consumption, and lung cancer risk in a pan-Canadian, non-smoking population. However, the sample size is modest, and further investigation is needed.

Idioma original	English
Páginas (desde-hasta)	913-918
Número de páginas	6
Publicación	Cancer Causes and Control
Volumen	33
N.º	6
DOI	https://doi.org/10.1007/s10552-022-01566-x
Estado	Published - jun. 2022

Nota bibliográfica

Funding Information:
This work was supported by Grants to Dr. Murphy from the Michael Smith Foundation for Health Research (Grant #17644) and the Canadian Institutes of Health Research (Grant #162510). The data used in this research were made available by the Canadian Partnership for Tomorrow’s Health funded by the Canadian Partnership Against Cancer and Health Canada, and by regional funders and host institutions including BC Cancer, Alberta Health Services, Alberta Cancer Foundation, Alberta Health, Ontario Institute for Cancer Research, Dalhousie University, University of Toronto, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Genome Quebec, and Genome Canada. The views expressed herein represent the views of the authors and do not necessarily represent the views of Health Canada or the provincial Governments. Parts of this material are based on data and information provided by Ontario Health (Cancer Care Ontario). The opinions, reviews, view and conclusions reported in this publication are those of the authors and do not necessarily reflect those of Ontario Health (Cancer Care Ontario). No endorsement by Ontario Health (Cancer Care Ontario) is intended or should be inferred.

Funding Information:
We acknowledge the support of all participants in the CanPath study who donated their time, personal health history and biological samples to this project. We also thank the CanPath and regional cohort team members for data collection and management. Regional cohorts included Alberta’s Tomorrow Project: https://myatp.ca , BC Generations Project: https://bcgenerationsproject.ca , CARTaGENE: https://cartagene.qc.ca/en , the Atlantic Partnership for Tomorrow’s Health: https://atlanticpath.ca , and the Ontario Health Study: https://ontariohealthstudy.ca. Alberta’s Tomorrow Project is only possible because of the commitment of its research participants, its staff and its funders: Alberta Health, Alberta Cancer Foundation, Canadian Partnership Against Cancer and Health Canada, and substantial in kind funding from Alberta Health Services. The views expressed herein represent the views of the author(s) and not of Alberta’s Tomorrow Project or any of its funders.

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

ASJC Scopus Subject Areas

Oncology
Cancer Research

PubMed: MeSH publication types

Journal Article

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Murphy, R. A., Darvishian, M., Qi, J., Chen, Y., Chu, Q., Vena, J., Dummer, T. J. B., Le, N., Sweeney, E., DeClercq, V., Grandy, S. A., Keats, M. R., Cui, Y., Awadalla, P., Brenner, D. R., & Bhatti, P. (2022). Lifestyle factors and lung cancer risk among never smokers in the Canadian Partnership for Tomorrow’s Health (CanPath). Cancer Causes and Control, 33(6), 913-918. https://doi.org/10.1007/s10552-022-01566-x

Murphy, RA, Darvishian, M, Qi, J, Chen, Y, Chu, Q, Vena, J, Dummer, TJB, Le, N, Sweeney, E , DeClercq, V, Grandy, SA, Keats, MR , Cui, Y, Awadalla, P, Brenner, DR & Bhatti, P 2022, 'Lifestyle factors and lung cancer risk among never smokers in the Canadian Partnership for Tomorrow’s Health (CanPath)', Cancer Causes and Control, vol. 33, n.º 6, pp. 913-918. https://doi.org/10.1007/s10552-022-01566-x

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abstract = "Background: Although smoking is the primary risk factor for lung cancer, 15–25% of lung cancers occur in never smokers. Emerging evidence suggests lifestyle factors are associated with lung cancer risk, but few studies among never smokers exist. Methods: A case–control study of never smokers within the Canadian Partnership for Tomorrow{\textquoteright}s Health was conducted. At recruitment, participants provided data on lifestyle, health history and sociodemographic factors. Incident lung cancers were identified through linkage with administrative health records. Cases (n = 190) were matched to controls (n = 760) on age, sex, and follow-up time. Logistic regression analyses, adjusted for matching factors and annual income, were used to identify associations between lifestyle factors and lung cancer risk. Results: Consumption of < 5 servings of fruits and vegetables/day was associated with higher risk of lung cancer (OR 1.50, 95% CI 1.03–2.17). Short or long sleep (≤ 6 or > 9 h/night) was also associated with increased risk of lung cancer (OR 1.52, 95% CI 1.01–2.29). No associations were observed for obesity measures, alcohol consumption, or physical activity. Conclusion: Our findings provide evidence of a potential role between sleep, fruits and vegetable consumption, and lung cancer risk in a pan-Canadian, non-smoking population. However, the sample size is modest, and further investigation is needed.",

author = "Murphy, {Rachel A.} and Maryam Darvishian and Jia Qi and Yixian Chen and Quincy Chu and Jennifer Vena and Dummer, {Trevor J.B.} and Nhu Le and Ellen Sweeney and Vanessa DeClercq and Grandy, {Scott A.} and Keats, {Melanie R.} and Yunsong Cui and Philip Awadalla and Brenner, {Darren R.} and Parveen Bhatti",

note = "Funding Information: This work was supported by Grants to Dr. Murphy from the Michael Smith Foundation for Health Research (Grant #17644) and the Canadian Institutes of Health Research (Grant #162510). The data used in this research were made available by the Canadian Partnership for Tomorrow{\textquoteright}s Health funded by the Canadian Partnership Against Cancer and Health Canada, and by regional funders and host institutions including BC Cancer, Alberta Health Services, Alberta Cancer Foundation, Alberta Health, Ontario Institute for Cancer Research, Dalhousie University, University of Toronto, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Genome Quebec, and Genome Canada. The views expressed herein represent the views of the authors and do not necessarily represent the views of Health Canada or the provincial Governments. Parts of this material are based on data and information provided by Ontario Health (Cancer Care Ontario). The opinions, reviews, view and conclusions reported in this publication are those of the authors and do not necessarily reflect those of Ontario Health (Cancer Care Ontario). No endorsement by Ontario Health (Cancer Care Ontario) is intended or should be inferred. Funding Information: We acknowledge the support of all participants in the CanPath study who donated their time, personal health history and biological samples to this project. We also thank the CanPath and regional cohort team members for data collection and management. Regional cohorts included Alberta{\textquoteright}s Tomorrow Project: https://myatp.ca , BC Generations Project: https://bcgenerationsproject.ca , CARTaGENE: https://cartagene.qc.ca/en , the Atlantic Partnership for Tomorrow{\textquoteright}s Health: https://atlanticpath.ca , and the Ontario Health Study: https://ontariohealthstudy.ca. Alberta{\textquoteright}s Tomorrow Project is only possible because of the commitment of its research participants, its staff and its funders: Alberta Health, Alberta Cancer Foundation, Canadian Partnership Against Cancer and Health Canada, and substantial in kind funding from Alberta Health Services. The views expressed herein represent the views of the author(s) and not of Alberta{\textquoteright}s Tomorrow Project or any of its funders. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.",

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AU - Vena, Jennifer

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N2 - Background: Although smoking is the primary risk factor for lung cancer, 15–25% of lung cancers occur in never smokers. Emerging evidence suggests lifestyle factors are associated with lung cancer risk, but few studies among never smokers exist. Methods: A case–control study of never smokers within the Canadian Partnership for Tomorrow’s Health was conducted. At recruitment, participants provided data on lifestyle, health history and sociodemographic factors. Incident lung cancers were identified through linkage with administrative health records. Cases (n = 190) were matched to controls (n = 760) on age, sex, and follow-up time. Logistic regression analyses, adjusted for matching factors and annual income, were used to identify associations between lifestyle factors and lung cancer risk. Results: Consumption of < 5 servings of fruits and vegetables/day was associated with higher risk of lung cancer (OR 1.50, 95% CI 1.03–2.17). Short or long sleep (≤ 6 or > 9 h/night) was also associated with increased risk of lung cancer (OR 1.52, 95% CI 1.01–2.29). No associations were observed for obesity measures, alcohol consumption, or physical activity. Conclusion: Our findings provide evidence of a potential role between sleep, fruits and vegetable consumption, and lung cancer risk in a pan-Canadian, non-smoking population. However, the sample size is modest, and further investigation is needed.

AB - Background: Although smoking is the primary risk factor for lung cancer, 15–25% of lung cancers occur in never smokers. Emerging evidence suggests lifestyle factors are associated with lung cancer risk, but few studies among never smokers exist. Methods: A case–control study of never smokers within the Canadian Partnership for Tomorrow’s Health was conducted. At recruitment, participants provided data on lifestyle, health history and sociodemographic factors. Incident lung cancers were identified through linkage with administrative health records. Cases (n = 190) were matched to controls (n = 760) on age, sex, and follow-up time. Logistic regression analyses, adjusted for matching factors and annual income, were used to identify associations between lifestyle factors and lung cancer risk. Results: Consumption of < 5 servings of fruits and vegetables/day was associated with higher risk of lung cancer (OR 1.50, 95% CI 1.03–2.17). Short or long sleep (≤ 6 or > 9 h/night) was also associated with increased risk of lung cancer (OR 1.52, 95% CI 1.01–2.29). No associations were observed for obesity measures, alcohol consumption, or physical activity. Conclusion: Our findings provide evidence of a potential role between sleep, fruits and vegetable consumption, and lung cancer risk in a pan-Canadian, non-smoking population. However, the sample size is modest, and further investigation is needed.

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Lifestyle factors and lung cancer risk among never smokers in the Canadian Partnership for Tomorrow’s Health (CanPath)

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

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