Localization of a type-specific antigenic site on herpes simplex virus type 2 glycoprotein D

W. E. Rawls; N. Balachandran; G. Sisson; R. J. Watson

doi:10.1128/jvi.51.1.263-265.1984

Localization of a type-specific antigenic site on herpes simplex virus type 2 glycoprotein D

W. E. Rawls, N. Balachandran, G. Sisson, R. J. Watson

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

3 Citas (Scopus)

Resumen

A herpes simplex virus type 1 strain isolated from a recurrent lesion of the nose reacted with monoclonal antibodies recognizing a type 2-specific site on glycoprotein D but not with monoclonal antibodies recognizing other type 2-specific sites. DNA sequence analysis of the glycoprotein D gene of the isolate revealed a single nucleotide alteration which changed the codon for asparagine to one encoding histidine at amino acid 97 in the protein. Histidine is located at this position in glycoprotein of herpes simplex virus type 2; thus, the monoclonal antibody 17βA3 recognizes an epitope located at this region of the protein.

Idioma original	English
Páginas (desde-hasta)	263-265
Número de páginas	3
Publicación	Journal of Virology
Volumen	51
N.º	1
DOI	https://doi.org/10.1128/jvi.51.1.263-265.1984
Estado	Published - 1984
Publicado de forma externa	Sí

ASJC Scopus Subject Areas

Microbiology
Immunology
Insect Science
Virology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

Acceder al documento

10.1128/jvi.51.1.263-265.1984

Otros archivos y enlaces

Citar esto

@article{c8d10225e6de44a181905b1cb2f0a492,

title = "Localization of a type-specific antigenic site on herpes simplex virus type 2 glycoprotein D",

abstract = "A herpes simplex virus type 1 strain isolated from a recurrent lesion of the nose reacted with monoclonal antibodies recognizing a type 2-specific site on glycoprotein D but not with monoclonal antibodies recognizing other type 2-specific sites. DNA sequence analysis of the glycoprotein D gene of the isolate revealed a single nucleotide alteration which changed the codon for asparagine to one encoding histidine at amino acid 97 in the protein. Histidine is located at this position in glycoprotein of herpes simplex virus type 2; thus, the monoclonal antibody 17βA3 recognizes an epitope located at this region of the protein.",

author = "Rawls, {W. E.} and N. Balachandran and G. Sisson and Watson, {R. J.}",

year = "1984",

doi = "10.1128/jvi.51.1.263-265.1984",

language = "English",

volume = "51",

pages = "263--265",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "1",

}

TY - JOUR

T1 - Localization of a type-specific antigenic site on herpes simplex virus type 2 glycoprotein D

AU - Rawls, W. E.

AU - Balachandran, N.

AU - Sisson, G.

AU - Watson, R. J.

PY - 1984

Y1 - 1984

N2 - A herpes simplex virus type 1 strain isolated from a recurrent lesion of the nose reacted with monoclonal antibodies recognizing a type 2-specific site on glycoprotein D but not with monoclonal antibodies recognizing other type 2-specific sites. DNA sequence analysis of the glycoprotein D gene of the isolate revealed a single nucleotide alteration which changed the codon for asparagine to one encoding histidine at amino acid 97 in the protein. Histidine is located at this position in glycoprotein of herpes simplex virus type 2; thus, the monoclonal antibody 17βA3 recognizes an epitope located at this region of the protein.

AB - A herpes simplex virus type 1 strain isolated from a recurrent lesion of the nose reacted with monoclonal antibodies recognizing a type 2-specific site on glycoprotein D but not with monoclonal antibodies recognizing other type 2-specific sites. DNA sequence analysis of the glycoprotein D gene of the isolate revealed a single nucleotide alteration which changed the codon for asparagine to one encoding histidine at amino acid 97 in the protein. Histidine is located at this position in glycoprotein of herpes simplex virus type 2; thus, the monoclonal antibody 17βA3 recognizes an epitope located at this region of the protein.

UR - http://www.scopus.com/inward/record.url?scp=0021238749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021238749&partnerID=8YFLogxK

U2 - 10.1128/jvi.51.1.263-265.1984

DO - 10.1128/jvi.51.1.263-265.1984

M3 - Article

C2 - 6202883

AN - SCOPUS:0021238749

SN - 0022-538X

VL - 51

SP - 263

EP - 265

JO - Journal of Virology

JF - Journal of Virology

IS - 1

ER -

Localization of a type-specific antigenic site on herpes simplex virus type 2 glycoprotein D

Resumen

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto