Lysophosphatidic acid signaling in obesity and insulin resistance

Kenneth D’Souza; Geena V. Paramel; Petra C. Kienesberger

doi:10.3390/nu10040399

Lysophosphatidic acid signaling in obesity and insulin resistance

Kenneth D’Souza, Geena V. Paramel, Petra C. Kienesberger

Medicine

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

59 Citas (Scopus)

Resumen

Although simple in structure, lysophosphatidic acid (LPA) is a potent bioactive lipid that profoundly influences cellular signaling and function upon binding to G protein-coupled receptors (LPA1-6). The majority of circulating LPA is produced by the secreted enzyme autotaxin (ATX). Alterations in LPA signaling, in conjunction with changes in autotaxin (ATX) expression and activity, have been implicated in metabolic and inflammatory disorders including obesity, insulin resistance, and cardiovascular disease. This review summarizes our current understanding of the sources and metabolism of LPA with focus on the influence of diet on circulating LPA. Furthermore, we explore how the ATX-LPA pathway impacts obesity and obesity-associated disorders, including impaired glucose homeostasis, insulin resistance, and cardiovascular disease.

Idioma original	English
Número de artículo	399
Publicación	Nutrients
Volumen	10
N.º	4
DOI	https://doi.org/10.3390/nu10040399
Estado	Published - abr. 2018

Nota bibliográfica

Funding Information:
Acknowledgments: This work was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant (RGPIN-2014-04454), and grants from the New Brunswick Health Research Foundation (NBHRF) and the Heart and Stroke Foundation of New Brunswick to P.C.K.; K.D.S. is a Killam Scholar and NSERC Vanier Scholar.

Funding Information:
This work was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant (RGPIN-2014-04454), and grants from the New Brunswick Health Research Foundation (NBHRF) and the Heart and Stroke Foundation of New Brunswick to P.C.K.; K.D.S. is a Killam Scholar and NSERC Vanier Scholar.

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.

ASJC Scopus Subject Areas

Food Science
Nutrition and Dietetics

ODS de las Naciones Unidas

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Lysophosphatidic acid signaling in obesity and insulin resistance

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ASJC Scopus Subject Areas

ODS de las Naciones Unidas

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