Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe

Medicine & Life Sciences

• GAT100 100%
• Allosteric Site 56%
• Cannabinoid Receptors 50%
• 5-chloro-3-ethyl-1H-indole-2-carboxylic acid (2-(4-piperidin-1-yl-phenyl)ethyl)amide 24%
• 1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)urea 19%
• Cannabinoid Receptor Modulators 6%
• rat Cnr1 protein 5%
• 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol 4%
• Arrestin 4%
• glyceryl 2-arachidonate 4%
• Ligands 4%
• Cannabinoid Receptor Agonists 3%
• anandamide 3%
• isothiocyanic acid 3%
• Endocannabinoids 3%
• G-Protein-Coupled Receptors 2%
• Lead 2%
• Libraries 2%
• Signal Transduction 2%
• Phosphorylation 1%
• Therapeutics 0%

Chemical Compounds

• Cannabinoid 50%
• Probe 24%
• Cannabinoid 1 Receptor Agonist 4%
• 2-Arachidonoylglycerol 4%
• Receptor Modulator 3%
• Anandamide 3%
• Endocannabinoid 3%
• Inverse Agonist 3%
• Isothiocyanate 2%
• Agonist 2%
• Antagonist 2%
• Label 2%
• Disorder 2%
• Ligand 1%