Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host Defence

Alejandro M. Palma, Mark R. Hanes, Jean S. Marshall

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18 Citas (Scopus)

Resumen

Mast cells are well known to be activated via cross-linking of immunoglobulins bound to surface receptors. They are also recognized as key initiators and regulators of both innate and adaptive immune responses against pathogens, especially in the skin and mucosal surfaces. Substantial attention has been given to the role of mast cells in regulating T cell function either directly or indirectly through actions on dendritic cells. In contrast, the ability of mast cells to modify B cell responses has been less explored. Several lines of evidence suggest that mast cells can greatly modify B cell generation and activities. Mast cells co-localise with B cells in many tissue settings and produce substantial amounts of cytokines, such as IL-6, with profound impacts on B cell development, class-switch recombination events, and subsequent antibody production. Mast cells have also been suggested to modulate the development and functions of regulatory B cells. In this review, we discuss the critical impacts of mast cells on B cells using information from both clinical and laboratory studies and consider the implications of these findings on the host response to infections.

Idioma originalEnglish
Número de artículo718499
PublicaciónFrontiers in Immunology
Volumen12
DOI
EstadoPublished - sep. 10 2021

Nota bibliográfica

Funding Information:
This work was funded by the Canadian Institutes of Health Research (CIHR grant number PJT-173350). MH is the recipient of a Beatrice Hunter Cancer Research Institute trainee award. AP is funded through an investigator award from the IWK Health Centre, Halifax, NS.

Publisher Copyright:
© Copyright © 2021 Palma, Hanes and Marshall.

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Immunology

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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