Resumen
Mast cells have historically been studied mainly in the context of allergic disease. In recent years, we have come to understand the critical importance of mast cells in tissue remodeling events and their role as sentinel cells in the induction and development of effective immune responses to infection. Studies of the role of mast cells in tumor immunity are more limited. The pro-tumorigenic role of mast cells has been widely reported. However, mast cell infiltration predicts improved prognosis in some cancers, suggesting that their prognostic value may be dependent on other variables. Such factors may include the nature of local mast cell subsets and the various activation stimuli present within the tumor microenvironment. Experimental models have highlighted the importance of mast cells in orchestrating the anti-tumor events that follow immunotherapies that target innate immunity. Mast cells are long-lived tissue resident cells that are abundant around many solid tumors and are radiation resistant making them unique candidates for combined treatment modalities. This review will examine some of the key roles of mast cells in tumor immunity, with a focus on potential immunotherapeutic interventions that harness the sentinel role of mast cells.
Idioma original | English |
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Páginas (desde-hasta) | 113-124 |
Número de páginas | 12 |
Publicación | Molecular Immunology |
Volumen | 63 |
N.º | 1 |
DOI | |
Estado | Published - ene. 2015 |
Nota bibliográfica
Funding Information:The authors’ research was supported by grants awarded to J.S.M from the Canadian Institutes of Health Research (grant # MOP93517) and the Canadian Cancer Society Research Institute (grant # 701381) and grants awarded to J.S.M and S.A.O from the Department of Defense Breast Cancer Research Program under award numbers W81XWH-10-1-0035 (J.S.M) and W81XWH-10-1-0036 (S.A.O). Views and opinions of, and endorsements by the authors do not reflect those of the US Army or the Department of Defense. We thank Dr. Ian Haidl for critical review of the manuscript.
Publisher Copyright:
© 2014 The Authors.
ASJC Scopus Subject Areas
- Immunology
- Molecular Biology