Measles Virus Infects and Programs MAIT Cells for Apoptosis

Patrick T. Rudak; Tony Yao; Christopher D. Richardson; S. M. Mansour Haeryfar

doi:10.1093/infdis/jiaa407

Measles Virus Infects and Programs MAIT Cells for Apoptosis

Patrick T. Rudak, Tony Yao, Christopher D. Richardson, S. M. Mansour Haeryfar

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

20 Citas (Scopus)

Resumen

Measles virus (MeV) binds, infects, and kills CD150+ memory T cells, leading to immune amnesia. Whether MeV targets innate, memory-like T cells is unknown. We demonstrate that human peripheral blood and hepatic mucosa-associated invariant T (MAIT) cells and invariant natural killer T cells express surprisingly high levels of CD150, more than other lymphocyte subsets. Furthermore, exposing MAIT cells to MeV results in their efficient infection and rapid apoptosis. This constitutes the first report of direct MAIT cell infection by a viral pathogen. Given MAIT cells' antimicrobial properties, their elimination by MeV may contribute to measles-induced immunosuppression and heightened vulnerability to unrelated infections.

Idioma original	English
Páginas (desde-hasta)	667-672
Número de páginas	6
Publicación	Journal of Infectious Diseases
Volumen	223
N.º	4
DOI	https://doi.org/10.1093/infdis/jiaa407
Estado	Published - feb. 15 2021

Nota bibliográfica

Publisher Copyright:
© 2020 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

ASJC Scopus Subject Areas

Immunology and Allergy
Infectious Diseases

PubMed: MeSH publication types

Journal Article
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abstract = "Measles virus (MeV) binds, infects, and kills CD150+ memory T cells, leading to immune amnesia. Whether MeV targets innate, memory-like T cells is unknown. We demonstrate that human peripheral blood and hepatic mucosa-associated invariant T (MAIT) cells and invariant natural killer T cells express surprisingly high levels of CD150, more than other lymphocyte subsets. Furthermore, exposing MAIT cells to MeV results in their efficient infection and rapid apoptosis. This constitutes the first report of direct MAIT cell infection by a viral pathogen. Given MAIT cells' antimicrobial properties, their elimination by MeV may contribute to measles-induced immunosuppression and heightened vulnerability to unrelated infections. ",

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AB - Measles virus (MeV) binds, infects, and kills CD150+ memory T cells, leading to immune amnesia. Whether MeV targets innate, memory-like T cells is unknown. We demonstrate that human peripheral blood and hepatic mucosa-associated invariant T (MAIT) cells and invariant natural killer T cells express surprisingly high levels of CD150, more than other lymphocyte subsets. Furthermore, exposing MAIT cells to MeV results in their efficient infection and rapid apoptosis. This constitutes the first report of direct MAIT cell infection by a viral pathogen. Given MAIT cells' antimicrobial properties, their elimination by MeV may contribute to measles-induced immunosuppression and heightened vulnerability to unrelated infections.

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Measles Virus Infects and Programs MAIT Cells for Apoptosis

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ASJC Scopus Subject Areas

PubMed: MeSH publication types

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