Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: The combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity

Shirya Rashid, Takehiko Watanabe, Taro Sakaue, Gary F. Lewis

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236 Citas (Scopus)

Resumen

Hypertriglyceridemia, low plasma concentrations of high density lipoproteins (HDL) and qualitative changes in low density lipoproteins (LDL) comprise the typical dyslipidemia of insulin resistant states and type 2 diabetes. Although isolated low plasma HDL-cholesterol (HDL-c) and apolipoprotein A-I (apo A-I, the major apolipoprotein component of HDL) can occur in the absence of hypertriglyceridemia or any other features of insulin resistance, the majority of cases in which HDL-c is low are closely linked with other clinical features of insulin resistance and hypertriglyceridemia. We and others have postulated that triglyceride enrichment of HDL particles secondary to enhanced CETP-mediated exchange of triglycerides and cholesteryl ester between HDL and triglyceride-rich lipoproteins, combined with the lipolytic action of hepatic lipase (HL), are driving forces in the reduction of plasma HDL-c and apoA-I plasma concentrations. The present review focuses on these metabolic alterations in insulin resistant states and their important contributions to the reduction of HDL-c and HDL-apoA-I plasma concentrations.

Idioma originalEnglish
Páginas (desde-hasta)421-429
Número de páginas9
PublicaciónClinical Biochemistry
Volumen36
N.º6
DOI
EstadoPublished - sep. 2003
Publicado de forma externa

ASJC Scopus Subject Areas

  • Clinical Biochemistry

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Profundice en los temas de investigación de 'Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: The combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity'. En conjunto forman una huella única.

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Rashid, S., Watanabe, T., Sakaue, T., & Lewis, G. F. (2003). Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: The combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity. Clinical Biochemistry, 36(6), 421-429. https://doi.org/10.1016/S0009-9120(03)00078-X