Resumen
We previously found that enveloped virus binding and penetration are necessary to initiate an interferonindependent, IRF3-mediated antiviral response. To investigate whether membrane perturbations that accompany membrane fusion-dependent enveloped-virus entry are necessary and sufficient for antiviral-state induction, we utilized a reovirus fusion-associated small transmembrane (FAST) protein. Membrane disturbances during FAST protein-mediated fusion, in the absence of additional innate immune response triggers, are sufficient to elicit interferon-stimulated gene induction and establishment of an antiviral state. Using sensors of membrane disruption to activate an IRF3-dependent, interferon-independent antiviral state may provide cells with a rapid, broad-spectrum innate immune response to enveloped-virus infections.
Idioma original | English |
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Páginas (desde-hasta) | 10926-10931 |
Número de páginas | 6 |
Publicación | Journal of Virology |
Volumen | 85 |
N.º | 20 |
DOI |
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Estado | Published - oct. 2011 |
ASJC Scopus Subject Areas
- Microbiology
- Immunology
- Insect Science
- Virology
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't