Membrane perturbation elicits an IRF3-dependent, interferon-independent antiviral response

Ryan S. Noyce, Kathryne Taylor, Marta Ciechonska, Susan E. Collins, Roy Duncan, Karen L. Mossman

Producción científica: Contribución a una revistaComentario/debaterevisión exhaustiva

39 Citas (Scopus)

Resumen

We previously found that enveloped virus binding and penetration are necessary to initiate an interferonindependent, IRF3-mediated antiviral response. To investigate whether membrane perturbations that accompany membrane fusion-dependent enveloped-virus entry are necessary and sufficient for antiviral-state induction, we utilized a reovirus fusion-associated small transmembrane (FAST) protein. Membrane disturbances during FAST protein-mediated fusion, in the absence of additional innate immune response triggers, are sufficient to elicit interferon-stimulated gene induction and establishment of an antiviral state. Using sensors of membrane disruption to activate an IRF3-dependent, interferon-independent antiviral state may provide cells with a rapid, broad-spectrum innate immune response to enveloped-virus infections.

Idioma originalEnglish
Páginas (desde-hasta)10926-10931
Número de páginas6
PublicaciónJournal of Virology
Volumen85
N.º20
DOI
EstadoPublished - oct. 2011

ASJC Scopus Subject Areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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