TY - JOUR
T1 - Meta-analysis of randomized controlled trials in dacryocystorhinostomy with and without silicone intubation
AU - Ing, Edsel B.
AU - Bedi, Harleen
AU - Hussain, Ahsen
AU - Zakrewski, Helena
AU - Ing, Royce
AU - Nijhawan, Navdeep
AU - Al-Sayyed, Amal
AU - Winn, Bryan J.
N1 - Publisher Copyright:
© 2017 Canadian Ophthalmological Society
PY - 2018/10
Y1 - 2018/10
N2 - Objective: To determine the effect of bicanalicular silicone intubation (SI) on dacryocystorhinostomy (DCR) success rate in adult primary acquired nasolacrimal duct obstruction. Design: Meta-analysis of randomized controlled trials (RCTs). Methods: PubMed, Embase, Cochrane CENTRAL, Ovid Medline, Google Scholar, and grey literature search was performed from inception to June 2017. All prospective DCR trials with randomization of SI were considered. Cases with non-SI or adjunctive mitomycin were excluded. Where possible we analysed only 1 eye from each subject. Random effects meta-analysis was performed. Results: We retrieved 1142 articles and after filtering there were 14 RCTs with a total of 1311 DCR cases. There were 444 external DCRs and pooled estimate showed risk ratio (RR) was 1.08 (95% confidence interval [CI] 1.01–1.15). There were 867 predominantly endonasal DCR with RR 1.04 (95% CI 0.99–1.09). When all DCR modalities were combined the RR was 1.05 (95% CI 1.01–1.09). Conclusions: Overall, there was a 5% statistically significant improvement in DCR success rate with SI, but more endonasal DCR RCTs are required.
AB - Objective: To determine the effect of bicanalicular silicone intubation (SI) on dacryocystorhinostomy (DCR) success rate in adult primary acquired nasolacrimal duct obstruction. Design: Meta-analysis of randomized controlled trials (RCTs). Methods: PubMed, Embase, Cochrane CENTRAL, Ovid Medline, Google Scholar, and grey literature search was performed from inception to June 2017. All prospective DCR trials with randomization of SI were considered. Cases with non-SI or adjunctive mitomycin were excluded. Where possible we analysed only 1 eye from each subject. Random effects meta-analysis was performed. Results: We retrieved 1142 articles and after filtering there were 14 RCTs with a total of 1311 DCR cases. There were 444 external DCRs and pooled estimate showed risk ratio (RR) was 1.08 (95% confidence interval [CI] 1.01–1.15). There were 867 predominantly endonasal DCR with RR 1.04 (95% CI 0.99–1.09). When all DCR modalities were combined the RR was 1.05 (95% CI 1.01–1.09). Conclusions: Overall, there was a 5% statistically significant improvement in DCR success rate with SI, but more endonasal DCR RCTs are required.
UR - http://www.scopus.com/inward/record.url?scp=85040973974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040973974&partnerID=8YFLogxK
U2 - 10.1016/j.jcjo.2017.12.006
DO - 10.1016/j.jcjo.2017.12.006
M3 - Article
C2 - 30340712
AN - SCOPUS:85040973974
SN - 0008-4182
VL - 53
SP - 466
EP - 470
JO - Canadian Journal of Ophthalmology
JF - Canadian Journal of Ophthalmology
IS - 5
ER -