Methyl red azo-reductase and its induction by 3-methylcholanthrene in the liver of different species

K. W. Renton

doi:10.3109/00498258009033751

Methyl red azo-reductase and its induction by 3-methylcholanthrene in the liver of different species

K. W. Renton

Medicine

Medicine

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8 Citas (Scopus)

Resumen

1. Methyl red azo-reductase activity in the liver cytosol of mouse and sheep was considerably less than in the rat, guinea-pig, rabbit and hamster. In the mouse, the total activity of this soluble enzyme to reduce methyl red was only 4% of that found in rat. 2. Species variation in methyl red azo-reductase of microsomes was relatively small compared to that of the cytosol. 3. Azo-reductase in the cytosol of mouse liver also differed from that of the rat in its resistance to the inductive effects of 3-methylcholanthrene.

Idioma original	English
Páginas (desde-hasta)	243-246
Número de páginas	4
Publicación	Xenobiotica
Volumen	10
N.º	4
DOI	https://doi.org/10.3109/00498258009033751
Estado	Published - 1980

Nota bibliográfica

Funding Information:
I am grateful to Mrs. Myrna Bueno-Espiritu for excellent technical assistance. This work was supported by a grant from the Medical Research Council of Canada. I am a Scholar of the Medical Research Council of Canada.

ASJC Scopus Subject Areas

Biochemistry
Toxicology
Pharmacology
Health, Toxicology and Mutagenesis

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title = "Methyl red azo-reductase and its induction by 3-methylcholanthrene in the liver of different species",

abstract = "1. Methyl red azo-reductase activity in the liver cytosol of mouse and sheep was considerably less than in the rat, guinea-pig, rabbit and hamster. In the mouse, the total activity of this soluble enzyme to reduce methyl red was only 4% of that found in rat. 2. Species variation in methyl red azo-reductase of microsomes was relatively small compared to that of the cytosol. 3. Azo-reductase in the cytosol of mouse liver also differed from that of the rat in its resistance to the inductive effects of 3-methylcholanthrene.",

author = "Renton, {K. W.}",

note = "Funding Information: I am grateful to Mrs. Myrna Bueno-Espiritu for excellent technical assistance. This work was supported by a grant from the Medical Research Council of Canada. I am a Scholar of the Medical Research Council of Canada.",

year = "1980",

doi = "10.3109/00498258009033751",

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T1 - Methyl red azo-reductase and its induction by 3-methylcholanthrene in the liver of different species

AU - Renton, K. W.

N1 - Funding Information: I am grateful to Mrs. Myrna Bueno-Espiritu for excellent technical assistance. This work was supported by a grant from the Medical Research Council of Canada. I am a Scholar of the Medical Research Council of Canada.

PY - 1980

Y1 - 1980

N2 - 1. Methyl red azo-reductase activity in the liver cytosol of mouse and sheep was considerably less than in the rat, guinea-pig, rabbit and hamster. In the mouse, the total activity of this soluble enzyme to reduce methyl red was only 4% of that found in rat. 2. Species variation in methyl red azo-reductase of microsomes was relatively small compared to that of the cytosol. 3. Azo-reductase in the cytosol of mouse liver also differed from that of the rat in its resistance to the inductive effects of 3-methylcholanthrene.

AB - 1. Methyl red azo-reductase activity in the liver cytosol of mouse and sheep was considerably less than in the rat, guinea-pig, rabbit and hamster. In the mouse, the total activity of this soluble enzyme to reduce methyl red was only 4% of that found in rat. 2. Species variation in methyl red azo-reductase of microsomes was relatively small compared to that of the cytosol. 3. Azo-reductase in the cytosol of mouse liver also differed from that of the rat in its resistance to the inductive effects of 3-methylcholanthrene.

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Methyl red azo-reductase and its induction by 3-methylcholanthrene in the liver of different species

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

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