Mixture regression analysis on age at onset in Bipolar Disorder patients: Investigation of the role of serotonergic genes

Mirko Manchia; Clement C. Zai; Alessio Squassina; John B. Vincent; Vincenzo De Luca; James L. Kennedy

doi:10.1016/j.euroneuro.2010.04.001

Mixture regression analysis on age at onset in Bipolar Disorder patients: Investigation of the role of serotonergic genes

Mirko Manchia, Clement C. Zai, Alessio Squassina, John B. Vincent, Vincenzo De Luca, James L. Kennedy

Medicine

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

18 Citas (Scopus)

Resumen

Bipolar Disorder (BPD) is a complex psychiatric disease with a relevant underlying genetic basis. HTR2A T102C, HTR2C Cys23Ser, SLC6A4 5-HTTLPR and rs25531 polymorphisms were genotyped in 230 BPD patients and inserted as covariates in a mixture regression model of age at onset (AAO). 5-HTTLPR polymorphism associated with early onset component under recessive and additive model. HTR2A T102C, HTR2C Cys23Ser and 5-HTTLPR interaction terms associated with early onset component under dominant, recessive and additive model. These findings suggest a role of genes codifying for elements of the serotonergic system in influencing the AAO in BPD.

Idioma original	English
Páginas (desde-hasta)	663-670
Número de páginas	8
Publicación	European Neuropsychopharmacology
Volumen	20
N.º	9
DOI	https://doi.org/10.1016/j.euroneuro.2010.04.001
Estado	Published - sep. 2010

Nota bibliográfica

Funding Information:
The study was supported by a Young Investigator Award from the National Alliance for Research and Schizophrenia and Depression (NARSAD) to Vincenzo De Luca. Mirko Manchia is now a PhD student in Neuroscience at the Department of Neurosciences “B.B. Brodie”, University of Cagliari, Italy. The funding sources were not involved in the data analysis and the preparation of the manuscript.

ASJC Scopus Subject Areas

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry
Pharmacology (medical)

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODS de las Naciones Unidas

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title = "Mixture regression analysis on age at onset in Bipolar Disorder patients: Investigation of the role of serotonergic genes",

abstract = "Bipolar Disorder (BPD) is a complex psychiatric disease with a relevant underlying genetic basis. HTR2A T102C, HTR2C Cys23Ser, SLC6A4 5-HTTLPR and rs25531 polymorphisms were genotyped in 230 BPD patients and inserted as covariates in a mixture regression model of age at onset (AAO). 5-HTTLPR polymorphism associated with early onset component under recessive and additive model. HTR2A T102C, HTR2C Cys23Ser and 5-HTTLPR interaction terms associated with early onset component under dominant, recessive and additive model. These findings suggest a role of genes codifying for elements of the serotonergic system in influencing the AAO in BPD.",

author = "Mirko Manchia and Zai, {Clement C.} and Alessio Squassina and Vincent, {John B.} and {De Luca}, Vincenzo and Kennedy, {James L.}",

note = "Funding Information: The study was supported by a Young Investigator Award from the National Alliance for Research and Schizophrenia and Depression (NARSAD) to Vincenzo De Luca. Mirko Manchia is now a PhD student in Neuroscience at the Department of Neurosciences “B.B. Brodie”, University of Cagliari, Italy. The funding sources were not involved in the data analysis and the preparation of the manuscript. ",

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AU - Squassina, Alessio

AU - Vincent, John B.

AU - De Luca, Vincenzo

AU - Kennedy, James L.

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AB - Bipolar Disorder (BPD) is a complex psychiatric disease with a relevant underlying genetic basis. HTR2A T102C, HTR2C Cys23Ser, SLC6A4 5-HTTLPR and rs25531 polymorphisms were genotyped in 230 BPD patients and inserted as covariates in a mixture regression model of age at onset (AAO). 5-HTTLPR polymorphism associated with early onset component under recessive and additive model. HTR2A T102C, HTR2C Cys23Ser and 5-HTTLPR interaction terms associated with early onset component under dominant, recessive and additive model. These findings suggest a role of genes codifying for elements of the serotonergic system in influencing the AAO in BPD.

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Mixture regression analysis on age at onset in Bipolar Disorder patients: Investigation of the role of serotonergic genes

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

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