N-Acetylcysteine treatment of neonatal acetaminophen toxicity caused by transplacental transfer–a case report

Garrett McDougall, Nancy G. Murphy, Osama Loubani

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

We describe a case of maternal acetaminophen toxicity leading to Caesarean section delivery of a pre-term neonate with acetaminophen-induced hepatic injury and encephalopathy at 33 weeks gestational age. Delayed treatment with N-acetylcysteine (NAC) was initiated in the baby 11 h after delivery, with eventual discharge of a healthy baby at 12 days of age. The baby was treated with a standard but extended duration NAC protocol. Post-operatively, liver biopsy of the mother demonstrated acetaminophen-induced hepatic injury overlying mild hepatic steatosis. This was also managed with NAC therapy leading to complete clinical resolution of acetaminophen induced hepatic injury and discharge on post-operative day 10. This case of delayed NAC therapy for the treatment of pre-term neonatal acetaminophen toxicity is one of very few reported in the literature and can be used as a guide in the management of subsequent cases.

Idioma originalEnglish
Páginas (desde-hasta)840-842
Número de páginas3
PublicaciónClinical Toxicology
Volumen59
N.º9
DOI
EstadoPublished - 2021

Nota bibliográfica

Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.

ASJC Scopus Subject Areas

  • Toxicology

PubMed: MeSH publication types

  • Case Reports
  • Journal Article

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